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Targeting PI3K in cancer: mechanisms and advances in clinical trials
Molecular Cancer, 2019 Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling is one of the most important intracellular pathways, which can be considered as a master regulator for cancer. Enormous efforts have been dedicated to the development
Jing Yang +5 more
semanticscholar +1 more source
Targeting the PI3K/Akt/mTOR pathway in non‐small cell lung cancer (NSCLC)
Thoracic Cancer, 2020 The traditional classification of lung cancer into small cell lung cancer and non‐small cell lung cancer (NSCLC) has been transformed with the increased understanding of the molecular alterations and genomic biomarkers that drive the development of lung ...
A. Tan
semanticscholar +1 more source
Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours
Cell & Bioscience, 2020 The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of signal transduction and biological processes such as cell proliferation, apoptosis, metabolism and angiogenesis.
Fei Xu, Lixin Na, Yanfei Li, Linjun Chen
semanticscholar +1 more source
Molecules, 2021 Lung cancer is one of the most common cancers and has a high mortality rate. Due to its high incidence, the clinical management of the disease remains a major challenge.
Iksen +2 more
semanticscholar +1 more source
Branched-Chain Amino Acid Negatively Regulates KLF15 Expression via PI3K-AKT Pathway. [PDF]
, 2017 Recent studies have linked branched-chain amino acid (BCAA) with numerous metabolic diseases. However, the molecular basis of BCAA's roles in metabolic regulation remains to be established.
Dong, Weibing +5 more
core +2 more sources
The PI3K/AKT pathway in obesity and type 2 diabetes
International Journal on Biological Sciences, 2018 Obesity and type 2 diabetes mellitus are complicated metabolic diseases that affect multiple organs and are characterized by hyperglycaemia. Currently, stable and effective treatments for obesity and type 2 diabetes mellitus are not available. Therefore,
Xingjun Huang +3 more
semanticscholar +1 more source
Role of PI3K/AKT pathway in cancer: the framework of malignant behavior
Molecular Biology Reports, 2020 Given that the PI3K/AKT pathway has manifested its compelling influence on multiple cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in various human cancers. We state the abnormalities of PI3K/AKT pathway in different
Ningni Jiang +5 more
semanticscholar +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Phosphoinositide-dependent protein kinase-1 (PDK1) is an important protein in mediating the PI3K-AKT pathway and is thus identified as a promising target.
Xinyuan Xu +6 more
doaj +1 more source
The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. [PDF]
, 2010 Deregulation of the phosphoinositide-3-OH kinase (PI(3)K) pathway has been implicated in numerous pathologies including cancer, diabetes, thrombosis, rheumatoid arthritis and asthma.
Alex Berndt +16 more
core +2 more sources
Drug Design, Development and Therapy, 2022 Zheng X, Yang S, Zhang R, Wang S, Li G, Zhou S. Drug Des Devel Ther. 2019;13:3171–3180. The authors have advised due to an error that occurred inadvertently at the time of figure assembly, Figure 5J is incorrect.
Zheng X +5 more
doaj