Results 21 to 30 of about 64,413 (204)

PI(4,5)P2 binding sites in the Ebola virus matrix protein VP40 modulate assembly and budding [PDF]

Journal of Lipid Research
Ebola virus (EBOV) causes severe hemorrhagic fever in humans and is lethal in a large percentage of those infected. The EBOV matrix protein viral protein 40 kDa (VP40) is a peripheral binding protein that forms a shell beneath the lipid bilayer in ...
Kristen A. Johnson, Melissa R. Budicini, Nisha Bhattarai, Tej Sharma, Sarah Urata, Bernard S. Gerstman, Prem P. Chapagain, Sheng Li, Robert V. Stahelin   +8 more
doaj   +2 more sources

PI(4,5)P2 regulates the gating of NaV1.4 channels. [PDF]

J Gen Physiol, 2023
Voltage-gated sodium (NaV) channels are densely expressed in most excitable cells and activate in response to depolarization, causing a rapid influx of Na+ ions that initiates the action potential. The voltage-dependent activation of NaV channels is followed almost instantaneously by fast inactivation, setting the refractory period of excitable tissues.
Gada KD, Kamuene JM, Chandrashekar A, Kissell RC, Yauch AK, Plant LD.   +5 more
europepmc   +3 more sources

The Dysferlin C2A Domain Binds PI(4,5)P2 and Penetrates Membranes. [PDF]

J Mol Biol, 2023
Dysferlin is a large membrane protein found most prominently in striated muscle. Loss of dysferlin activity is associated with reduced exocytosis, abnormal intracellular Ca2+ and the muscle diseases limb-girdle muscular dystrophy and Miyoshi myopathy. The cytosolic region of dysferlin consists of seven C2 domains with mutations in the C2A domain at the
Kwok E, Otto SC, Khuu P, Carpenter AP, Codding SJ, Reardon PN, Vanegas J, Kumar TM, Kuykendall CJ, Mehl RA, Baio J, Johnson CP.   +11 more
europepmc   +3 more sources

Loss of OCRL increases ciliary PI(4,5)P2 in Lowe oculocerebrorenal syndrome [PDF]

Journal of Cell Science, 2017
Lowe syndrome is a rare X-linked disorder characterized by bilateral congenital cataracts and glaucoma, mental retardation, and proximal renal tubular dysfunction. Mutations in OCRL, an inositol polyphosphate 5-phosphatase that dephosphorylates PI(4,5)P2,
Alvarado, Jorge A., Hu, Yang, Luo, Na, Prosseda, Philipp P., Sun, Yang, Wang, Biao   +5 more
core   +5 more sources

TXNIP interaction with GLUT1 depends on PI(4,5)P₂. [PDF]

Biochim Biophys Acta Biomembr, 2021
GLUT1 is a major glucose facilitator expressed ubiquitously among tissues. Upregulation of its expression plays an important role in the development of many types of cancer and metabolic diseases. Thioredoxin-interacting protein (TXNIP) is an α-arrestin that acts as an adaptor for GLUT1 in clathrin-mediated endocytosis.
Dykstra H, LaRose C, Fisk C, Waldhart A, Meng X, Zhao G, Wu N.   +6 more
europepmc   +3 more sources

PI(4,5)P2 controls slit diaphragm formation and endocytosis in Drosophila nephrocytes. [PDF]

Cell Mol Life Sci, 2022
Abstract Drosophila nephrocytes are an emerging model system for mammalian podocytes and proximal tubules as well as for the investigation of kidney diseases. Like podocytes, nephrocytes exhibit characteristics of epithelial cells, but the role of phospholipids in polarization of these cells is
Gass MM, Borkowsky S, Lotz ML, Siwek R, Schröter R, Nedvetsky P, Luschnig S, Rohlmann A, Missler M, Krahn MP.   +9 more
europepmc   +3 more sources

Physiological Calcium Concentrations Induce PI(4,5)P2 Clustering: PI(4,5)P2 as a Lipidic Calcium Sensor [PDF]

Biophysical Journal, 2013
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a minor component of the plasma membrane of eukaryotic cells that is essential for several cellular mechanisms, including organization and remodeling of the actin cytoskeleton, membrane trafficking, endocytosis and exocytosis.
João Sarmento, Maria, Coutinho, Ana, Fedorov, Aleksander, Prieto, Manuel, Fernandes, Fábio   +4 more
openaire   +1 more source

Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]

, 2004
Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Morales-Johansson, Helena
core   +2 more sources

Mechanisms of PI(4,5)P2 Enrichment in HIV-1 Viral Membranes. [PDF]

J Mol Biol, 2020
Phosphatidylinositol 4,5-bisphosphate (PIP2) is critical for HIV-1 virus assembly. The viral membrane is enriched in PIP2, suggesting that the virus assembles at PIP2-rich microdomains. We showed previously that in model membranes PIP2 can form nanoscopic clusters bridged by multivalent cations.
Wen Y, Feigenson GW, Vogt VM, Dick RA.
europepmc   +3 more sources

Does PI(4,5)P2 Regulate Voltage-Gated Potassium Channels? [PDF]

Biophysical Journal, 2012
Phosphatidylinositol −4,5-bisphosphate (PI(4,5)P2) is an important regulator of activity of a variety of ion channels including inwardly rectifying potassium channels, KCNQ, TRP, and voltage-gated calcium channels. Several groups have provided evidence that also voltage-gated potassium (Kv) channels might be regulated by PI(4,5)P2.
Kruse, Martin, Hammond, Gerald R.V., Hille, Bertil   +2 more
openaire   +4 more sources