Results 31 to 40 of about 64,413 (204)
eLife, 2020 Synaptic vesicle (SV) endocytosis is coupled to exocytosis to maintain SV pool size and thus neurotransmitter release. Intense stimulation induces activity-dependent bulk endocytosis (ADBE) to recapture large quantities of SV constituents in large ...
Tsai-Ning Li +5 more
doaj +1 more source
Translocation between PI(4,5)P2-Poor and PI(4,5)P2-Rich Microdomains During Store Depletion Determines STIM1 Conformation and Gating of Orai1 [PDF]
Biophysical Journal, 2015 Shmuel Muallem1, Jozsef Maleth1,2,4, Seok Choi1,3,4, and Malini Ahuja1From the 1Epithelial Signaling and Transport Section, NIDCR, NIH, Bethesda MD, 20892, 2First Department of Medicine, University of Szeged, Szeged, Hungary, 3Department of Physiology, Chosun University, South KoreaReceptor-stimulated Ca2+ influx, a critical component of the Ca2 ...
Muallem, Shmuel +3 more
openaire +5 more sources
Membrane-mediated dimerization potentiates PIP5K lipid kinase activity
eLife, 2022 The phosphatidylinositol 4-phosphate 5-kinase (PIP5K) family of lipid-modifying enzymes generate the majority of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] lipids found at the plasma membrane in eukaryotic cells.
Scott D Hansen +3 more
doaj +1 more source
Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate [PDF]
, 2015 During the late stages of the HIV-1 replication cycle, the viral polyprotein Pr55(Gag) is recruited to the plasma membrane (PM), where it binds phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and directs HIV-1 assembly. We show that Rab27a controls the
Amigorena, S. +16 more
core +4 more sources
Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis
eLife, 2017 Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] is essential for exocytosis. Classical ways of manipulating PI(4,5)P2 levels are slower than its metabolism, making it difficult to distinguish effects of PI(4,5)P2 from those of its metabolites.
Alexander M Walter +15 more
doaj +1 more source
Phospholipid binding to the FAK catalytic domain impacts function. [PDF]
PLoS ONE, 2017 Focal adhesion kinase is an essential nonreceptor tyrosine kinase that plays an important role in development, in homeostasis and in the progression of human disease.
Jessica E Hall, Michael D Schaller
doaj +1 more source
eLife, 2022 Synaptic communication relies on the fusion of synaptic vesicles with the plasma membrane, which leads to neurotransmitter release. This exocytosis is triggered by brief and local elevations of intracellular Ca2+ with remarkably high sensitivity.
Janus RL Kobbersmed +4 more
doaj +1 more source
Structural insights on TRPV5 gating by endogenous modulators. [PDF]
, 2018 TRPV5 is a transient receptor potential channel involved in calcium reabsorption. Here we investigate the interaction of two endogenous modulators with TRPV5.
Carnevale, Vincenzo +13 more
core +3 more sources
Competitive PIRT and PI(4,5)P2 Interactions Modulate TRPM8 [PDF]
Biophysical Journal, 2016 Phosphoinositide regulator of TRP (PIRT) is a small human membrane protein that has been shown to modulate the function of specific TRP channels. PIRT has been implicated in fine-tuning the roles that TRP channels play in thermosensing, ligand activation, and pruritus.
Sisco, Nicholas J. +2 more
openaire +1 more source
Absence of clustering of phosphatidylinositol-(4,5)-bisphosphate in fluid phosphatidylcholine
Journal of Lipid Research, 2006 Phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2] plays a key role in the modulation of actin polymerization and vesicle trafficking. These processes seem to depend on the enrichment of PI(4,5)P2 in plasma membrane domains. Here, we show that PI(4,5)P2
Faébio Fernandes +3 more
doaj +1 more source