Lamin A/C and PI(4,5)P2-A Novel Complex in the Cell Nucleus. [PDF]
Cells, 2019 Lamins, the nuclear intermediate filaments, are important regulators of nuclear structural integrity as well as nuclear functional processes such as DNA transcription, replication and repair, and epigenetic regulations. A portion of phosphorylated lamin A/C localizes to the nuclear interior in interphase, forming a lamin A/C pool with specific ...
Escudeiro-Lopes S +3 more
europepmc +5 more sources
A role for eisosomes in maintenance of plasma membrane phosphoinositide levels [PDF]
, 2014 The plasma membrane delineates the cell and mediates its communication and material exchange with the environment. Many processes of the plasma membrane occur through interactions of proteins with phosphatidylinositol(4,5)-bisphosphate (PI(4,5)P2), which
Alcazar-Roman, Abel +5 more
core +1 more source
Ca2+ induces PI(4,5)P2 clusters on lipid bilayers at physiological PI(4,5)P2 and Ca2+ concentrations
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2014 Calcium has been shown to induce clustering of PI(4,5)P2 at high and non-physiological concentrations of both the divalent ion and the phosphatidylinositol, or on supported lipid monolayers. In lipid bilayers at physiological conditions, clusters are not detected through microscopic techniques.
Sarmento, Maria J. +4 more
openaire +2 more sources
Cell Reports, 2017 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) signaling is transient and spatially confined in live cells. How this pattern of signaling regulates transmitter release and hormone secretion has not been addressed. We devised an optogenetic approach to
Chen Ji, Fan Fan, Xuelin Lou
doaj +1 more source
Topological organisation of the phosphatidylinositol 4,5-bisphosphate-phospholipase C resynthesis cycle: PITPs bridge the ER-PM gap [PDF]
, 2016 Phospholipase C (PLC) is a receptor-regulated enzyme that hydrolyses phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) at the plasma membrane (PM) triggering three biochemical consequences, the generation of soluble inositol 1,4,5-trisphosphate (IP3 ...
Cockcroft, S, Raghu, P
core +1 more source
The Ebola Virus matrix protein, VP40, requires phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) for extensive oligomerization at the plasma membrane and viral egress [PDF]
, 2016 VP40 is one of eight proteins encoded by the Ebola Virus (EBOV) and serves as the primary matrix protein, forming virus like particles (VLPs) from mammalian cells without the need for other EBOV proteins.
Johnson, Kristen A. +3 more
core +1 more source
PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism
Cell Reports, 2019 Summary: Insulin stimulates the conversion of phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) to phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3), which mediates downstream cellular responses.
Diana G. Wang +14 more
doaj +1 more source
The Inositol 5-Phosphatase dOCRL Controls PI(4,5)P2 Homeostasis and Is Necessary for Cytokinesis [PDF]
, 2011 SummaryDuring cytokinesis, constriction of an equatorial actomyosin ring physically separates the two daughter cells. At the cleavage furrow, the phosphoinositide PI(4,5)P2 plays an important role by recruiting and regulating essential proteins of the ...
Amin A +13 more
core +1 more source
Optogenetic dephosphorylation of phosphatidylinositol 4,5 bisphosphate in Xenopus laevis oocytes
STAR Protocols, 2023 Summary: Here, we present a protocol for optogenetic dephosphorylation of the phosphoinositide PI(4,5)P2 at the plasma membrane of Xenopus laevis oocytes. We first describe the co-injection of oocytes with cRNAs encoding (1) a light-activated PI(4,5)P2 5-
Kirin D. Gada +6 more
doaj +1 more source
New Experimental Trends for Phosphoinositides Research on Ion Transporter/Channel Regulation
Journal of Pharmacological Sciences, 2014 .: Phosphoinositides(4,5)-bisphosphates [PI(4,5)P2] critically controls membrane excitability, the disruption of which leads to pathophysiological states.
Masayuki X. Mori, Ryuji Inoue
doaj +1 more source