Results 31 to 40 of about 24,514 (173)

Antiviral Development for the Polio Endgame: Current Progress and Future Directions

Pathogens
As the world is approaching the eradication of wild poliovirus serotype 1, the last of the three wild types, the question of how to maintain a polio-free world becomes imminent.
Hang Xie, Eric E. Rhoden, Hong-Mei Liu, Folake Ogunsemowo, Bernardo A. Mainou, Rachel M. Burke, Cara C. Burns   +6 more
doaj   +1 more source

Isolation and molecular characterization of a novel picornavirus from baitfish in the USA.

PLoS ONE, 2014
During both regulatory and routine surveillance sampling of baitfish from the states of Illinois, Minnesota, Montana, and Wisconsin, USA, isolates (n = 20) of a previously unknown picornavirus were obtained from kidney/spleen or entire viscera of fathead
Nicholas B D Phelps, Sunil K Mor, Anibal G Armien, William Batts, Andrew E Goodwin, Lacey Hopper, Rebekah McCann, Terry Fei Fan Ng, Corey Puzach, Thomas B Waltzek, Eric Delwart, James Winton, Sagar M Goyal   +12 more
doaj   +1 more source

Highly diverse ribonucleic acid viruses in the viromes of eukaryotic host species in Yunnan province, China

Frontiers in Microbiology, 2022
BackgroundThe diversity in currently documented viruses and their morphological characteristics indicates the need for understanding the evolutionary characteristics of viruses.
Zhenzhi Han, Zhenzhi Han, Jinbo Xiao, Yang Song, Xiaonan Zhao, Qiang Sun, Huanhuan Lu, Keyi Zhang, Jichen Li, Junhan Li, Fenfen Si, Guoyan Zhang, Hehe Zhao, Senquan Jia, Jienan Zhou, Dongyan Wang, Shuangli Zhu, Dongmei Yan, Wenbo Xu, Wenbo Xu, Xiaoqing Fu, Yong Zhang, Yong Zhang   +22 more
doaj   +1 more source

Picornaviruses and Apoptosis: Subversion of Cell Death

mBio, 2017
Infected cells can undergo apoptosis as a protective response to viral infection, thereby limiting viral infection. As viruses require a viable cell for replication, the death of the cell limits cellular functions that are required for virus replication ...
Sarah N. Croft, Erin J. Walker, Reena Ghildyal   +2 more
doaj   +1 more source

A comparative analysis of parechovirus protein structures with other picornaviruses

Open Biology, 2021
Parechoviruses belong to the genus Parechovirus within the family Picornaviridae and are non-enveloped icosahedral viruses with a single-stranded RNA genome. Parechoviruses include human and animal pathogens classified into six species. Those that infect
Aušra Domanska, Sergey Guryanov, Sarah J. Butcher   +2 more
doaj   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Purification and concentration of model viruses using single‐pass tangential flow filtration

Biotechnology Progress, EarlyView.
Single‐pass TFF was developed for an enveloped and non‐enveloped virus for use in continuous downstream purification processes. Enveloped virus was concentrated and purified. Abstract The vaccine and viral vector industry is growing at an accelerated rate.
Luis Alberto Mejía‐Manzano, Lynn Manchester, Grace Wallis, Kan Wang, Bruce P. Lee, Michael Betenbaugh, Caryn L. Heldt   +6 more
wiley   +1 more source

Tracking poliovirus through wastewater: environmental surveillance insights from Haïti (2020–2023)

Applied and Environmental Microbiology
Environmental surveillance (ES) for poliovirus is a critical component of global eradication efforts, enabling the detection of virus circulation in communities, even in the absence of acute flaccid paralysis (AFP) cases.
Hanen Belgasmi-Allen, Jamaica Hill, Stacey Jeffries Miles, Leanna Sayyad, Hala Elahi, Nicole E. Patterson, Ashley Deas, Amelus Heberlienne, Amanda Wilkinson, Everardo Vega, Cara C. Burns, Nancy Gerloff   +11 more
doaj   +1 more source

Enterovirus Transmission by Secretory Autophagy

Viruses, 2018
Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes.
Yael Mutsafi, Nihal Altan-Bonnet
doaj   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source