Results 41 to 50 of about 32,243 (222)

Picornavirus inhibitors

Pharmacology & Therapeutics, 1994
Picornaviruses are among the best understood animal viruses in molecular terms. A number of important human and animal pathogens are members of the Picornaviridae family. The genome organization, the different steps of picornavirus growth and numerous compounds that have been reported as inhibitors of picornavirus functions are reviewed.
openaire   +2 more sources

The Enterovirus 71 A-particle Forms a Gateway to Allow Genome Release: A CryoEM Study of Picornavirus Uncoating [PDF]

, 2013
Since its discovery in 1969, enterovirus 71 (EV71) has emerged as a serious worldwide health threat. This human pathogen of the picornavirus family causes hand, foot, and mouth disease, and also has the capacity to invade the central nervous system to ...
AD Stuart, Alexander M. Makhov, AT Hadfield, B Yang, BA Brown, BA Phillips, BA Phillips, CC Liu, CE Fricks, CW Tan, D Bubeck, D Garriga, DC Ansardi, DM Belnap, EF Pettersen, Félix A. Rey, G Bilek, G Tang, H Oppermann, J Lin, James F. Conway, JD Yoder, Jennifer L. Yoder, JJ Holland, JK Lewis, JM Greve, JM Hogle, JP Alexander Jr, Kristin L. Shingler, LG Chan, M Bostina, MF Jacobson, MF Jacobson, MG Rossmann, MG Rossmann, Michael S. Carnegie, NJ Schmidt, P Chacon, P Danthi, P Plevka, P Verdino, P Zhang, PC McMinn, PY Su, Q Li, R Basavappa, Robert E. Ashley, S Curry, S Curry, S Yamayoshi, S Yamayoshi, SL Yang, Susan Hafenstein, TJ Tuthill, X Wang, X Yan, Y Ghendon, Y Huang, Y Nishimura, Y Watanabe   +59 more
core   +3 more sources

Highly diverse ribonucleic acid viruses in the viromes of eukaryotic host species in Yunnan province, China

Frontiers in Microbiology, 2022
BackgroundThe diversity in currently documented viruses and their morphological characteristics indicates the need for understanding the evolutionary characteristics of viruses.
Zhenzhi Han, Zhenzhi Han, Jinbo Xiao, Yang Song, Xiaonan Zhao, Qiang Sun, Huanhuan Lu, Keyi Zhang, Jichen Li, Junhan Li, Fenfen Si, Guoyan Zhang, Hehe Zhao, Senquan Jia, Jienan Zhou, Dongyan Wang, Shuangli Zhu, Dongmei Yan, Wenbo Xu, Wenbo Xu, Xiaoqing Fu, Yong Zhang, Yong Zhang   +22 more
doaj   +1 more source

Picornaviruses and Apoptosis: Subversion of Cell Death

mBio, 2017
Infected cells can undergo apoptosis as a protective response to viral infection, thereby limiting viral infection. As viruses require a viable cell for replication, the death of the cell limits cellular functions that are required for virus replication ...
Sarah N. Croft, Erin J. Walker, Reena Ghildyal   +2 more
doaj   +1 more source

A comparative analysis of parechovirus protein structures with other picornaviruses

Open Biology, 2021
Parechoviruses belong to the genus Parechovirus within the family Picornaviridae and are non-enveloped icosahedral viruses with a single-stranded RNA genome. Parechoviruses include human and animal pathogens classified into six species. Those that infect
Aušra Domanska, Sergey Guryanov, Sarah J. Butcher   +2 more
doaj   +1 more source

Rhinovirus detection using different PCR-based strategies [PDF]

, 2012
Human rhinoviruses (HRVs) are the major cause of the common cold. HRVs were recently reclassified into the Enterovirus genus (HEV) in the Picornaviridae family.
Bellei, Nancy Cristina Junqueira, Carraro, Emerson, Granato, Celso Francisco Hernandes, Perosa, Ana Helena Sitta, Silva, Ellen Ricci Monteiro da, Watanabe, Aripuanã Sakurada Aranha   +5 more
core   +1 more source

Autoimmunity in picornavirus infections

Current Opinion in Virology, 2016
Enteroviruses are small, non-enveloped, positive-sense single-strand RNA viruses, and are ubiquitously found throughout the world. These viruses usually cause asymptomatic or mild febrile illnesses, but have a propensity to induce severe diseases including type 1 diabetes and pancreatitis, paralysis and neuroinflammatory disease, myocarditis, or ...
Massilamany, Chandirasegara, Koenig, Andreas, Reddy, Jay, Huber, Sally, Buskiewicz, Iwona   +4 more
openaire   +3 more sources

Picornavirus Infection Leading to Immunosuppression [PDF]

Future Virology, 2014
Viruses, such as HIV, hepatitis A, poliovirus, coxsackievirus B3 and foot-and-mouth disease virus, use a variety of mechanisms to suppress the human immune system in order to evade clearance by the host. Therefore, investigating how a few changes in the viral genome of a nonlethal virus can lead to an alteration in disease, from survivable to ...
Matthew F, Cusick, Jane E, Libbey, Robert S, Fujinami   +2 more
openaire   +2 more sources

Identification of Capsid/Coat Related Protein Folds and Their Utility for Virus Classification [PDF]

, 2017
The viral supergroup includes the entire collection of known and unknown viruses that roam our planet and infect life forms. The supergroup is remarkably diverse both in its genetics and morphology and has historically remained difficult to study and ...
Arshan Nasir, Gustavo Caetano-Anollés
core   +1 more source

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, EarlyView.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source