Results 71 to 80 of about 24,514 (173)

The Contribution of Microglia and Brain-Infiltrating Macrophages to the Pathogenesis of Neuroinflammatory and Neurodegenerative Diseases during TMEV Infection of the Central Nervous System

Viruses
The infection of the central nervous system (CNS) with neurotropic viruses induces neuroinflammation and is associated with the development of neuroinflammatory and neurodegenerative diseases, including multiple sclerosis and epilepsy.
Ana Beatriz DePaula-Silva
doaj   +1 more source

Structure and function of type IV IRES in picornaviruses: a systematic review

Frontiers in Microbiology
The Picornaviridae is a family of icosahedral viruses with single-stranded, highly diverse positive-sense RNA genomes. Virions consist of a capsid, without envelope, surrounding a core of RNA genome.
Yan Li, Yan Li, Lei Zhang, Ling Wang, Jing Li, Yanwei Zhao, Fuxiao Liu, Qianqian Wang   +7 more
doaj   +1 more source

Early Steps of Picornavirus Infection

Uirusu, 2011
Picornaviridae is a large family of viruses that cause a variety of infectious diseases in humans and animals. It includes important viruses such as poliovirus, hepatisis A virus and foot and mouth disease virus. Early steps of infection play important roles in determining the host range and the target organs for each virus.
openaire   +3 more sources

Bovine Rhinitis B Virus Variant as the Putative Cause of Bronchitis in Goat Kids

Viruses
A diagnostic investigation into an outbreak of fatal respiratory disease among young goats in Iowa, USA revealed bronchitis lesions of unknown etiology and secondary bacterial bronchopneumonia.
Andrew Noel, Jianqiang Zhang, Huigang Shen, Anugrah Saxena, Jennifer Groeltz-Thrush, Ganwu Li, Michael C. Rahe   +6 more
doaj   +1 more source

Effective Treatment of Established GL261 Murine Gliomas through Picornavirus Vaccination-Enhanced Tumor Antigen-Specific CD8+ T Cell Responses.

PLoS ONE, 2015
Glioblastoma (GBM) is among the most invasive and lethal of cancers, frequently infiltrating surrounding healthy tissue and giving rise to rapid recurrence.
Danielle N Renner, Fang Jin, Adam J Litterman, Alexis J Balgeman, Lisa M Hanson, Jeffrey D Gamez, Michael Chae, Brett L Carlson, Jann N Sarkaria, Ian F Parney, John R Ohlfest, Istvan Pirko, Kevin D Pavelko, Aaron J Johnson   +13 more
doaj   +1 more source

Picornaviruses and nuclear functions: targeting a cellular compartment distinct from the replication site of a positive-strand RNA virus

Frontiers in Microbiology, 2015
The compartmentalization of DNA replication and gene transcription in the nucleus and protein production in the cytoplasm is a defining feature of eukaryotic cells.
Dylan eFlather, Bert L Semler
doaj   +1 more source

A tandem repeat gene in a picornavirus

Nucleic Acids Research, 1982
Three closely related genes for the small genome-linked protein (VPg) of picornaviruses have been identified by sequence analysis as a tandem repeat in the genome of Foot and Mouth Disease Virus (FMDV), strain O1K. This unusual structure was also found in the genome of strain C1O, belonging to a different FMDV serotype. Predicted biochemical properties
S, Forss, H, Schaller
openaire   +3 more sources

Diversity and Evolution of Viral Pathogen Community in Cave Nectar Bats (Eonycteris spelaea)

Viruses, 2019
Bats are unique mammals, exhibit distinctive life history traits and have unique immunological approaches to suppression of viral diseases upon infection.
Ian H Mendenhall, Dolyce Low Hong Wen, Jayanthi Jayakumar, Vithiagaran Gunalan, Linfa Wang, Sebastian Mauer-Stroh, Yvonne C.F. Su, Gavin J.D. Smith   +7 more
doaj   +1 more source

Cellular entry and uncoating of naked and quasi-enveloped human hepatoviruses

eLife, 2019
Many ‘non-enveloped’ viruses, including hepatitis A virus (HAV), are released non-lytically from infected cells as infectious, quasi-enveloped virions cloaked in host membranes.
Efraín E Rivera-Serrano, Olga González-López, Anshuman Das, Stanley M Lemon   +3 more
doaj   +1 more source

TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions

mBio, 2017
Receptor molecules play key roles in the cellular entry of picornaviruses, and TIM1 (HAVCR1) is widely accepted to be the receptor for hepatitis A virus (HAV), an unusual, hepatotropic human picornavirus.
Anshuman Das, Asuka Hirai-Yuki, Olga González-López, Bethany Rhein, Sven Moller-Tank, Rachel Brouillette, Lucinda Hensley, Ichiro Misumi, William Lovell, John M. Cullen, Jason K. Whitmire, Wendy Maury, Stanley M. Lemon   +12 more
doaj   +1 more source