Results 71 to 80 of about 26,015 (214)

Heat shock protein 90 chaperone activity is required for hepatitis A virus replication

Journal of Virology
HSP90 heat shock chaperones are essential for maintaining cellular proteostasis, as well as the ATP-dependent folding and functional maturation of many viral proteins. As a result, inhibitors of HSP90 have broad antiviral activity, disrupting replication
You Li, Xin Zheng, Ling Xie, Maryna Kapustina, Takayoshi Shirasaki, Bryan Yonish, Xian Chen, Asuka Hirai-Yuki, Noriyo Nagata, Ryosuke Suzuki, Masanori Isogawa, Matthew R. Vogt, Masamichi Muramatsu, Stanley M. Lemon   +13 more
doaj   +1 more source

Virome Variation during Sea Star Wasting Disease Progression in Pisaster ochraceus (Asteroidea, Echinodermata)

Viruses, 2020
Sea star wasting disease (SSWD) is a condition that has affected asteroids for over 120 years, yet mechanistic understanding of this wasting etiology remains elusive.
Ian Hewson, Citlalli A. Aquino, Christopher M. DeRito   +2 more
doaj   +1 more source

Surfactant‐Enhanced Electrospun Nanofiber Filters for Efficient Viral and Bacterial Inactivation

Journal of Applied Polymer Science, Volume 143, Issue 13, April 5, 2026.
In this work, electrospun polyacrylonitrile (PAN) nanofibrous filters functionalized with surfactants (CTAB, CPC, and SDS) were developed for air filtration applications. The PAN nanofiber mats enable efficient particulate matter capture while simultaneously providing antimicrobial and antiviral activity against bacteria (E. coli and S.
Edilton N. da Silva, Paulo A. M. Chagas, Gustavo C. da Mata, Felipe A. Lima, Fabiana B. Furtado, Wanderley P. de Oliveira, Rejane M. T. Grotto, Clovis W. O. de Souza, Mônica L. Aguiar, Vádila G. Guerra   +9 more
wiley   +1 more source

The Importance of Solution Studies for the Structural Characterization of the Enterovirus 5’ Cloverleaf

Viruses
Enteroviruses initiate genomic replication via a highly conserved mechanism that is controlled by an RNA platform, also known as the 5’ cloverleaf (5’CL).
Morgan G. Daniels, Meagan E. Werner, Xiaobing Zuo, Steven M. Pascal   +3 more
doaj   +1 more source

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

Advanced Science, Volume 13, Issue 24, 27 April 2026.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu, Hang Li, Peng Liu, Zhe Jiao, Ding Zhang, Zhelin Su, Sai Niu, Jintao Zhang, Yuejun Shi, Guiqing Peng   +9 more
wiley   +1 more source

Phylogenetic analysis of picornavirus 3D gene sequences.

, 2014
Phylogenetic analysis on the basis of amino acid sequence of complete picornavirus 3D gene. The evolutionary history was inferred using the Maximum likelihood method in MEGA5.
Terry Fei Fan Ng (218510), Nicholas B. D. Phelps (525839), William Batts (525842), Sunil K. Mor (525840), Rebekah McCann (525844), Eric Delwart (123223), Andrew E. Goodwin (487826), James Winton (525846), Corey Puzach (525845), Sagar M. Goyal (370303), Anibal G. Armien (525841), Lacey Hopper (525843), Thomas B. Waltzek (510001)   +12 more
core   +1 more source

Picornavirus Modification of a Host mRNA Decay Protein [PDF]

, 2012
Due to the limited coding capacity of picornavirus genomic RNAs, host RNA binding proteins play essential roles during viral translation and RNA replication.
Semler, B. L, Janet M. Rozovics, Gershon, P. D, Paul D. Gershon, Cathcart, A. L, Saiprasad Palusa, Chase, A. J, Rozovics, J. M, Wilusz, J., Chou, W., Amanda J. Chase, Palusa, S., Jeffrey Wilusz, Andrea L. Cathcart, Bert L. Semler, Wayne Chou   +15 more
core   +1 more source

A Tutorial for Isolating, Characterizing, and Inducing Presenescence in Human Periodontal Ligament and Dental Pulp Stem Cells

Current Protocols, Volume 6, Issue 4, April 2026.
Abstract For several years, scientists have focused on studying mesenchymal stem cells because of their ability for self‐regeneration, their potential for differentiation into multiple lineages (e.g., osteogenic, chondrogenic, and adipogenic cells), and their low immunogenicity and remarkable capacity to modulate the immune system.
Kamila Sauer Veiga Leme, Márjorie de Assis Golim, Aline Márcia Marques Braz, Elenice Deffune, Daisy Maria Fávero Salvadori   +4 more
wiley   +1 more source

Oncolytic Therapy: Delivery System and New Therapeutic Strategies for Cancer

MedComm, Volume 7, Issue 4, April 2026.
This review summarizes recent advances in nanoparticle‐ and cell‐mediated OVs delivery strategies that improve biodistribution and tumor targeting while limiting immune clearance. It also examines combination approaches that enhance therapeutic efficacy through tumor microenvironment modulation or immune activation, thereby overcoming immunosuppression
Sikan Jin, Yi Zhang, Ziling Zhou, Yaqi Zhang, Ting Yu, Rui Xu, Lin Xu, Jidong Zhang, Longze Zhang, Shan Yang, Xianyao Wang   +10 more
wiley   +1 more source

An insect picornavirus may have genome organization similar to that of caliciviruses

, 1992
Computer-assisted analysis of the amino acid sequence of the product encoded by the sequenced 3′ portion of the cricket paralysis virus (CrPV), an insect picornavirus, genome showed that this protein is homologous not to the RNA-directed RNA polymerases,
Gorbalenya, Alexander E., Koonin, Eugene V., Alexander E. Gorbalenya, Eugene V. Koonin   +3 more
core   +1 more source