Results 81 to 90 of about 32,053 (206)

Heat shock protein 90 chaperone activity is required for hepatitis A virus replication

Journal of Virology
HSP90 heat shock chaperones are essential for maintaining cellular proteostasis, as well as the ATP-dependent folding and functional maturation of many viral proteins. As a result, inhibitors of HSP90 have broad antiviral activity, disrupting replication
You Li, Xin Zheng, Ling Xie, Maryna Kapustina, Takayoshi Shirasaki, Bryan Yonish, Xian Chen, Asuka Hirai-Yuki, Noriyo Nagata, Ryosuke Suzuki, Masanori Isogawa, Matthew R. Vogt, Masamichi Muramatsu, Stanley M. Lemon   +13 more
doaj   +1 more source

Main Protease From SARS‐CoV‐2 Dysregulates Glucose Handling in the C2C12 Cell Line In Vitro: A Mechanistic Study

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background There is evidence demonstrating the risk of developing diabetes mellitus because of SARS‐CoV‐2 infection. Therefore, further research is needed to determine pathological mechanisms at which SARS‐CoV‐2 induces diabetes mellitus. This study therefore aims to understand the effect of SARS‐CoV‐2 Main protease (Mpro) on glucose uptake ...
Praise Tatenda Nhau, Mlindeli Gamede, Andile Khathi, Ntethelelo Sibiya   +3 more
wiley   +1 more source

Complete Genome Sequence of a Divergent Human Rhinovirus C Isolate from an Infant with Severe Community-Acquired Pneumonia in Colorado, USA. [PDF]

, 2017
Here, we report the genome sequence of a divergent human rhinovirus C isolate identified from an infant with a severe community-acquired respiratory infection. RNA sequencing performed on an Illumina platform identified reads aligning to human rhinovirus
DeRisi, Joseph L, Langelier, Charles, Mourani, Peter M, Sontag, Marci K, White, Corin V   +4 more
core   +2 more sources

The Importance of Solution Studies for the Structural Characterization of the Enterovirus 5’ Cloverleaf

Viruses
Enteroviruses initiate genomic replication via a highly conserved mechanism that is controlled by an RNA platform, also known as the 5’ cloverleaf (5’CL).
Morgan G. Daniels, Meagan E. Werner, Xiaobing Zuo, Steven M. Pascal   +3 more
doaj   +1 more source

Rhinovirus Infects B and CD4 T Lymphocytes in Hypertrophic Tonsils in Children

Journal of Medical Virology, Volume 98, Issue 2, February 2026.
ABSTRACT Prolonged detection of rhinovirus (RV) in secretions after a typical cold and asymptomatic shedding are frequently reported. Although RV has been detected in human hypertrophic tonsils, its replicative status and host cell range remain unclear.
Ronaldo Martins, Flavia E. de Paula, Talita B. G. Mitchell, Miria F. Criado, Ricardo S. Cardoso, Bruna L. S. Jesus, Italo A. Castro, Murilo Henrique Anzolini Cassiano, Daniela Méria Ramos Rodrigues, Noilson Oliveira, Lucas Carenzi, Fabiana C. Valera, Edwin Tamashiro, Wilma T. Anselmo‐Lima, Eurico Arruda   +14 more
wiley   +1 more source

Isolation of poliovirus 2C mutants defective in viral RNA synthesis [PDF]

, 1988
Two poliovirus mutants were isolated that contain an oligonucleotide linker insertion in the 2C-coding region of the viral genome. One, 2C-31, has a strongly temperature-sensitive phenotype and the other, 2C-32, forms small plaques on HeLa cell ...
Baltimore, David, Li, Jing-Po
core  

Lack of Genetic Diversity in Newly Sequenced Porcine Circovirus Type 1 Strains Isolated 20 Years Apart [PDF]

The complete genome sequences of a porcine circovirus type 1 (PCV1) strain isolated in 1990 and one isolated in 2011 were obtained and compared to the sequences of other available PCV1 isolates.
Baylis, Gilliland, Quintana, Rose, Saha, Tischer, Tischer, Victoria   +7 more
core   +1 more source

Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model [PDF]

, 2016
published_or_final_versio
Chan, BC, Chan, KH, Chen, Z, Fan, YY, Lam, SF, Lau, SKP, Li, KSM, Woo, PCY, Yip, CY, Yuen, KY, Yuen, MC, Zhang, HJ, Zhang, J   +12 more
core   +1 more source

Insect I‐Type Lysozymes Function as Antiviral Proteases by Forming Biomolecular Condensates

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Upon rice viral infection, the insect vector activates the Toll–MyD88–Dorsal signaling cascade, inducing i‐type lysozyme (Lyz‐I1) expression. Lyz‐I1 functions as an antiviral protease through its conserved catalytic dyad Glu/Asp (E/D), mediating cleavage of viral proteins at specific Lys (K) residues.
Yu Du, Yuqing Xiao, Manman Hu, Jinhua Yang, You Li, Taiyun Wei   +5 more
wiley   +1 more source

Insights into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate. [PDF]

, 2010
Accepted ...
Allaire, Belsham, Belsham, Bergmann, Birtley, Birtley, Bjorndahl, Blom, Brunger, Brünger, Carrillo, Cordingley, Cordingley, Curry, Curry, Delano, Ellard, Frigerio, Fujinaga, Graham J. Belsham, Grubman, Grubman, Hedstrom, Hodis, Huber, Jaulent, Jewell, Jingjie Yang, Jones, Laskowski, Lee, Li, Long, Matthews, Matthews, McCoy, Mosimann, Nayak, Núria Roqué-Rosell, Pallai, Patricia A. Zunszain, Perona, Perona, Perona, Phan, Prasad, Reid, Robin J. Leatherbarrow, Schechter, Seipelt, Skern, Stephen Curry, Stephen R. Knox, Sutmoller, Sweeney, Trevor R. Sweeney, Tsunogae, Xue, Yin, Yin   +59 more
core   +1 more source