Results 1 to 10 of about 37,375 (191)
Cancer Management and Research, 2020 Xiao Lu,1,* Quan-Xing Liu,1,* Jiao Zhang,1 Dong Zhou,1 Gui-Xue Yang,1 Man-Yuan Li,1 Yuan Qiu,2 Qian Chen,3 Hong Zheng,1 Ji-Gang Dai1 1Department of Thoracic Surgery, Xinqiao Hospital, Army Medical University, Chongqing 400037, People’s Republic of ...
Lu X +9 more
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The role of DJ-1 in enhancing mitochondrial quality control [PDF]
, 2013 Thesis (M.A.)--Boston UniversityDJ-1 is a cytosolic sensor for oxidative damage which acts on the Mitochondria. It works to curb the negative effects of high membrane potential in mitochondria, but the mechanism of action is still uncertain.
Lingiah, Krishna Anand
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The Aging Heart: Mitophagy at the Center of Rejuvenation. [PDF]
, 2020 Aging is associated with structural and functional changes in the heart and is a major risk factor in developing cardiovascular disease. Many recent studies have focused on increasing our understanding of the basis of aging at the cellular and molecular ...
Gustafsson, Åsa B, Liang, Wenjing J
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Defining the organizational structure of dopamine and muscarninic acetylcholine receptors [PDF]
, 2015 No abstract ...
Alvarez-Curto, Elisa +4 more
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NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions.
PLoS ONE, 2015 Mutations of the PTEN-induced putative kinase 1 (PINK1) gene are a cause of autosomal recessive forms of Parkinson's disease. Recent studies have revealed that PINK1 is an essential factor for controlling mitochondrial quality, and that it protects cells
Hitoshi Murata +5 more
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The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants.
PLoS Genetics, 2012 Pink1 is a mitochondrial kinase involved in Parkinson's disease, and loss of Pink1 function affects mitochondrial morphology via a pathway involving Parkin and components of the mitochondrial remodeling machinery.
Sven Vilain +9 more
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Mitochondrial Quality Control in Age-Related Pulmonary Fibrosis. [PDF]
, 2020 Idiopathic pulmonary fibrosis (IPF) is age-related interstitial lung disease of unknown etiology. About 100,000 people in the U.S have IPF, with a 3-year median life expectancy post-diagnosis.
Cuevas-Mora, Karina +2 more
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Parkin uses the UPS to ship off dysfunctional mitochondria [PDF]
, 2011 Parkin is a ubiquitin E3 ligase that is implicated in familial Parkinson disease (PD). Previous studies have established its role in mitophagy, a pathway whereby dysfunctional mitochondria are targeted for autophagic degradation.
Chan, David C., Chan, Nickie C.
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Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells [PDF]
, 2016 Background: Loss of a cell’s capacity to generate sufficient energy for cellular functions is a key hallmark of the ageing process and ultimately leads to a variety of important age-related pathologies such as cancer, Parkinson’s disease and ...
Docherty, Craig K. +2 more
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Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. [PDF]
, 2017 Increased α-synuclein (αsyn) and mitochondrial dysfunction play central roles in the pathogenesis of Parkinson's disease (PD), and lowering αsyn is under intensive investigation as a therapeutic strategy for PD. Increased αsyn levels disrupt mitochondria
Bendor, Jacob T +9 more
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