Results 41 to 50 of about 37,375 (191)
Parkin-independent mitophagy controls chemotherapeutic response in cancer cells [PDF]
, 2017 Mitophagy is an evolutionarily conserved process that selectively targets impaired mitochondria for degradation. Defects in mitophagy are often associated with diverse pathologies, including cancer.
Bossowski, Jozef P. +13 more
core +2 more sources
PINK1, cancer and neurodegeneration
Oncoscience, 2016 Cancer and neurodegeneration are two age-related diseases that arise from aberrant signaling in similar cellular systems, those that balance survival and death. Thus, deregulated molecular processes such as DNA damage repair, intracellular energy balance, and key signal transduction systems, including the PI3-kinase/Akt axis can promote tumorigenesis ...
Ciara H, O'Flanagan +2 more
openaire +2 more sources
Open Biology, 2022 Autosomal recessive mutations in the PINK1 gene are causal for Parkinson's disease (PD). PINK1 encodes a mitochondrial localized protein kinase that is a master-regulator of mitochondrial quality control pathways.
Poonam Kakade +14 more
doaj +1 more source
Parkin interacts with Ambra1 to induce mitophagy [PDF]
, 2011 Mutations in the gene encoding Parkin are a major cause of recessive Parkinson's disease. Recent work has shown that Parkin translocates from the cytosol to depolarized mitochondria and induces their autophagic removal (mitophagy). However, the molecular
Cornelissen, Tom +6 more
core +2 more sources
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology [PDF]
Cell Reports, 2018 PINK1 and Parkin mediate mitophagy, the cellular process that clears dysfunctional mitochondria. Mitophagy is regulated by mitochondrial dynamics, but the molecules linking these two processes remain poorly understood. Here, we show that Sam50, the core component of the sorting and assembly machinery (SAM), is a critical regulator of mitochondrial ...
Jian, Fenglei +9 more
openaire +3 more sources
RBR E3 ubiquitin ligases: new structures, new insights, new questions [PDF]
, 2014 The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain enzymes.
Shaw, Gary S. +2 more
core +1 more source
PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control [PDF]
Cell Death & Disease, 2016 AbstractMitochondrial dysfunction has been linked to the pathogenesis of a large number of inherited diseases in humans, including Parkinson’s disease, the second most common neurodegenerative disorder. The Parkinson’s disease genes pink1 and parkin, which encode a mitochondrially targeted protein kinase, and an E3 ubiquitin ligase, respectively ...
Zhuang, Na +3 more
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The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking [PDF]
Journal of Neurochemistry, 2011 Intramembrane proteolysis is a conserved mechanism that regulates a variety of cellular processes ranging from transcription control to signaling. In mitochondria, the inner membrane rhomboid protease PARL has been implicated in the control of life span and apoptosis by a so far uncharacterized mechanism.
Cathrin Meissner +4 more
openaire +3 more sources
The effect of 4 weeks of continuous aerobic training with different volumes and starvation on the expression of some genes involved in liver mitophagy in healthy male Wistar rats [PDF]
ورزش و علوم زیست حرکتیIntroduction and Purpose: An increase in the number of defective mitochondria and their persistence can lead to apoptosis and necrosis of cells. Regular physical exercise along with time-restricted eating (TRE) can play an important role in improving ...
Hamzeh Bayani +3 more
doaj +1 more source
The PINK1/Parkin pathway: a mitochondrial quality control system? [PDF]
, 2009 Significant insight into the mechanisms that contribute to dopaminergic neurodegeneration in Parkinson disease has been gained from the analysis of genes linked to rare heritable forms of parkinsonism such as PINK1 and parkin, loss-of-function mutations ...
Pallanck, L.J., Whitworth, A.J.
core +1 more source