Results 61 to 70 of about 15,787 (93)
Mitochondrial Quality Control in Age-Related Pulmonary Fibrosis. [PDF]
, 2020 Idiopathic pulmonary fibrosis (IPF) is age-related interstitial lung disease of unknown etiology. About 100,000 people in the U.S have IPF, with a 3-year median life expectancy post-diagnosis.
Cuevas-Mora, Karina +2 more
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Signal transducer and activator of transcription-1 localizes to the mitochondria and modulates mitophagy [PDF]
, 2013 The signal transducer and activator of transcription (STAT) proteins are latent transcription factors that have been shown to be involved in cell proliferation, development, apoptosis, and autophagy. STAT proteins undergo activation by phosphorylation at
Ambrosio G +9 more
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PINK1 function in health and disease
EMBO Molecular Medicine, 2009 The role of mitochondria in sporadic Parkinson's disease (PD) has been debated for a little over 20 years since the description of complex I deficiency in the substantia nigra pars compacta (SNpc) of PD patients. However, the identification of recessive pathogenic mutations in the pink1 gene in familial PD cases firmly re-ignited interest in the ...
Deas, Emma +2 more
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PINK1 mediates neuronal survival in monkey [PDF]
Protein & Cell, 2021 Sun, Zhiyu, Ye, Jiangyu, Yuan, Junying
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Bioenergetic Consequences of PINK1 Mutations in Parkinson Disease [PDF]
, 2011 Background: Mutations of the gene for PTEN-induced kinase 1 (PINK1) are a cause of familial Parkinson's disease (PD). PINK1 protein has been localised to mitochondria and PINK1 gene knockout models exhibit abnormal mitochondrial function.
Abramov, AY +5 more
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Characterization of Vesicular Monoamine Transporter 2 and its role in Parkinson\u27s Disease Pathogenesis using Drosophila [PDF]
, 2016 Parkinson’s disease (PD) is a progressive neurodegenerative disorder caused by the selective loss of the dopaminergic neurons in the Substantia nigra pars compacta region of the brain.
Tito, Antonio Joel, Jr., Zhang, Sheng
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Mitochondrial quality control beyond PINK1/Parkin
Oncotarget, 2018 von Stockum Sophia +2 more
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Biochemical and Biophysical Research Communications, 2023
Parkinson's disease is presently thought to have its molecular roots in the alteration of PINK1-mediated mitophagy and mitochondrial dynamics. Finding new suppressors of the pathway is essential for developing cutting-edge treatment approaches. Our study shows that FUNDC1 suppressed PINK1 mutant phenotypes in Drosophila.
Jing, Xu +4 more
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Parkinson's disease is presently thought to have its molecular roots in the alteration of PINK1-mediated mitophagy and mitochondrial dynamics. Finding new suppressors of the pathway is essential for developing cutting-edge treatment approaches. Our study shows that FUNDC1 suppressed PINK1 mutant phenotypes in Drosophila.
Jing, Xu +4 more
openaire +2 more sources