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Catalytic Enantioselective Synthesis of 3-Piperidines from Arylboronic Acids and Pyridine [PDF]

open access: yesJournal of the American Chemical Society, 2023
Piperidines are frequently found in natural products and are of importance to the pharmaceutical industry. A generally useful asymmetric route to enantiomerically enriched 3-substituted piperidines remains elusive.
Sourabh Mishra, Stephen P Fletcher
exaly   +6 more sources

Synthesis of piperidines and pyridine from furfural over a surface single-atom alloy Ru1CoNP catalyst [PDF]

open access: yesNature Communications, 2023
The sustainable production of value-added N-heterocycles from available biomass allows to reduce the reliance on fossil resources and creates possibilities for economically and ecologically improved synthesis of fine and bulk chemicals.
Haifeng Qi   +14 more
doaj   +3 more sources

[Co(TPP)]‐Catalyzed Formation of Substituted Piperidines [PDF]

open access: yesChemistry - A European Journal, 2019
Radical cyclization via cobalt(III)‐carbene radical intermediates is a powerful method for the synthesis of (hetero)cyclic structures. Building on the recently reported synthesis of five‐membered N‐heterocyclic pyrrolidines catalyzed by CoII porphyrins ...
Bas De Bruin, Ching-ping Wong
exaly   +4 more sources

Mannich Reactions of Carbohydrate Derivatives with Ketones To Afford Polyoxy-Functionalized Piperidines [PDF]

open access: yesOrganic Letters, 2019
Mannich reactions of carbohydrate derivatives with ketones that afford polyoxy-functionalized piperidines are reported. Ketone nucleophiles (enamines/enolates) were generated in the presence of the amines used for the formation of the iminium ions of ...
Fujie Tanaka, Lingaiah Maram
core   +4 more sources

Über γ‐substituierte Piperidine [PDF]

open access: greenBerichte der deutschen chemischen Gesellschaft, 1915
n ...
Ernst Koenigs, Ludwig Neumann
openalex   +4 more sources

Gold(I)–catalyzed enantioselective annulations between allenes and alkene-tethered oxime ethers: A straight entry to highly substituted piperidines and aza-bridged medium-sized carbocycles [PDF]

open access: yesJournal of the American Chemical Society, 2018
NOTICE: This is the peer reviewed version of the following article: Marcote, D. C., Varela, I., Fernández-Casado, J., Mascareñas, J.L., López*, F. (2019), Gold(I)–catalyzed enantioselective annulations between allenes and alkene-tethered oxime ethers: A
Cagiao Marcote, David   +4 more
core   +4 more sources

Electrochemical Aminoxyl-Mediated α-Cyanation of Secondary Piperidines for Pharmaceutical Building Block Diversification

open access: yesJournal of the American Chemical Society, 2018
Secondary piperidines are ideal pharmaceutical building blocks owing to the prevalence of piperidines in commercial drugs. Here, we report an electrochemical method for cyanation of the heterocycle adjacent to nitrogen without requiring protection or ...
Shannon L Goes   +2 more
exaly   +2 more sources

Recent Progresses in the Catalytic Stereoselective Dearomatization of Pyridines. [PDF]

open access: yesMolecules, 2023
1,2- and 1,4-dihydropyridines and N-substituted 2-pyridones are very important structural motifs due to their synthetic versatility and vast presence in a variety of alkaloids and bioactive molecules.
Comparini LM, Pineschi M.
europepmc   +3 more sources

Harnessing the Electrophilicity of Keteniminium Ions: A Simple and Straightforward Entry to Tetrahydropyridines and Piperidines from Ynamides

open access: yesAngewandte Chemie - International Edition, 2016
An efficient, modular and straightforward entry to tetrahydropyridines and piperidines is reported. This reaction is based on a formal intramolecular hydroalkylation of readily available, properly substituted ynamides which, upon simple activation under ...
Morgan Lecomte, Gwilherm Evano
exaly   +2 more sources

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