Results 131 to 140 of about 47,089 (385)

Synthesis of N‐Substituted 4‐Pyridones From Skipped Diynones via Intramolecular Base or Ag(I)‐Catalyzed Hydroamination

Asian Journal of Organic Chemistry, EarlyView.
A general protocol for the synthesis of N‐substituted 4‐pyridones from skipped diynones is presented via a base or Ag(I)‐catalyzed hydroamination pathway. Abstract Cs2CO3 or CF3COOAg catalyze the intramolecular 6‐endo hydroamination of the Z‐enaminones derived from the Michael‐type addition of primary amines to skipped diynones, yielding N‐substituted ...
Elisavet‐Maria Zantioti‐Chatzouda, Stavroula‐Aikaterini Kaplani, Eleni‐Maria Stroda, Nikolaos Eleftheriadis, Manolis Stratakis   +4 more
wiley   +1 more source

Modular Synthesis of Pyritide‐Inspired Macrocycles Featuring Bipyridine Motifs

Angewandte Chemie, EarlyView.
A pyritide‐inspired build/couple/pair strategy yields a diverse macrocycle library. This approach expands chemical space and enables the discovery of 6paW, a potent anti‐ferroptotic agent. Abstract Macrocycles represent a promising class of drug‐like scaffolds with unique structural features and the ability to engage challenging targets such as protein–
Ji Hyae Lee, Sihyeong Yi, Juhyun Bang, Hyun Choi, Seung Bum Park   +4 more
wiley   +2 more sources

Prins fluorination cyclisations: Preparation of 4-fluoro-pyran and -piperidine heterocycles

Beilstein Journal of Organic Chemistry, 2010
The Prins reaction was investigated using BF3·OEt2 as a Lewis acid. It has been recently demonstrated, that if BF3·OEt2 is used in stoichiometric amounts then these reactions generate fluorinated products where the BF3·OEt2 contributes fluoride ion to ...
Guillaume G. Launay, Alexandra M. Z. Slawin, David O'Hagan   +2 more
doaj   +1 more source

Pentannulation of N-heterocycles by a tandem gold-catalyzed [3,3]-rearrangement/Nazarov reaction of propargyl ester derivatives: a computational study on the crucial role of the nitrogen atom

Beilstein Journal of Organic Chemistry, 2020
The tandem gold(I)-catalyzed rearrangement/Nazarov reaction of enynyl acetates in which the double bond is embedded in a piperidine ring was computationally and experimentally studied.
Giovanna Zanella, Martina Petrović, Dina Scarpi, Ernesto G. Occhiato, Enrique Gómez-Bengoa   +4 more
doaj   +1 more source

Oxalates as Activating Groups for Alcohols in Visible Light Photoredox Catalysis: Formation of Quaternary Centers by Redox-Neutral Fragment Coupling. [PDF]

, 2015
Alkyl oxalates are new bench-stable alcohol-activating groups for radical generation under visible light photoredox conditions. Using these precursors, the first net redox-neutral coupling of tertiary and secondary alcohols with electron-deficient ...
Jamison, Christopher R, MacMillan, David WC, Nawrat, Christopher C, Overman, Larry E, Slutskyy, Yuriy   +4 more
core  

N‐Amino Peptide–Graphene Quantum Dot Loaded Small Extracellular Vesicles for Targeted Therapy of Tauopathies

Advanced NanoBiomed Research, EarlyView.
A neuron‐targeting drug delivery system is developed by incorporating the tau‐specific N‐amino peptide, mxyl‐NAP2, with graphene quantum dots (GQDs) and encapsulating the complex into small extracellular vesicles functionalized with a neuron‐targeting ligand.
Runyao Zhu, Gaeun Kim, Benjamin H. Rajewski, Isaac J. Angera, Juan R. Del Valle, Yichun Wang   +5 more
wiley   +1 more source

Metalloamination/Cyclization of Zinc(II) Amides Derived from N,N-Dimethylhydrazinoalkenes—Applications for the Direct C-SP² Functionalization of Aryl and Vinyl Electrophiles

Inorganics
Treatment of N,N-dimethylhydrazinoalkenes with diethylzinc followed by exposure of the resulting ethylzinc amides to high vacuum drives a Schlenck redistribution metalloamination/cyclization to generate the corresponding bis(organozinc) intermediates in ...
Jérome Lépeule, Christian Frabitore, Tom Livinghouse   +2 more
doaj   +1 more source

New One-Pot Methodologies for the Modification or Synthesis of Alkaloid Scaffolds

Marine Drugs, 2010
There are several avenues by which promising bioactive natural products can be produced in sufficient quantities to enable lead optimization and medicinal chemistry studies. The total synthesis of natural products is an important, but sometimes difficult,
Amir E. Wahba, Mark T. Hamann
doaj   +1 more source

Nickel-Catalyzed Asymmetric Reductive Cross-Coupling between Heteroaryl Iodides and α-Chloronitriles [PDF]

, 2015
A Ni-catalyzed asymmetric reductive cross-coupling of heteroaryl iodides and α-chloronitriles has been developed. This method furnishes enantioenriched α,α-disubstituted nitriles from simple organohalide building blocks.
Kadunce, Nathaniel T., Reisman, Sarah E.
core   +4 more sources

Highly enantioselective hydroamination to six-membered rings by heterobimetallic catalysts [PDF]

, 2014
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Biyikal, Mustafa, Blechert, Siegfried, Hussein, Lenard, Purkait, Nibadita, Roesky, Peter W., Tausch, Eugenia   +5 more
core   +1 more source