Results 131 to 140 of about 23,915 (334)
Angewandte Chemie, EarlyView.Wir präsentieren eine Nanodroplet‐Array‐Plattform, die die Integration von Festphasensynthese, MALDI‐MS‐Analyse und zellbasiertem Screening von 325 potenziellen MEK‐Inhibitoren (Mitogen‐aktivierte‐Proteinkinase‐Kinase) in Nanoliter‐Volumina ermöglicht.
Maximilian Seifermann +10 more
wiley +1 more source
[[alternative]]Designs and Syntheses of Glycosidase Inhibitors and Analogues from D-Quinic Acid [PDF]
計畫編號：NSC92-2113-M032-004研究期間：200308~200407研究經費：827,000[[sponsorship ...
施增廉
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Total synthesis of (±)-paroxetine by diastereoconvergent cobalt-catalysed arylation
, 2014 A total synthesis of paroxetine is reported, with a diastereoselective and diastereoconvergent cobalt-catalysed sp3–sp2 coupling reaction involving a 3-substituted 4-bromo-N-Boc-piperidine (Boc = tert-butoxycarbonyl) substrate as a key step.
Despiau, Carole F. +3 more
core +2 more sources
5-Hydroxy-Piperidine-2-Carboxylic Acid in Green Plants. [PDF]
, 1954 Artturi I. Virtanen +3 more
openalex +1 more source
Research progress of donepezil for treating mild to moderate Alzheimer's disease
Chinese Journal of Contemporary Neurology and Neurosurgery, 2017 Donepezil is the second generation of cholinesterase inhibitors (ChEIs), which has a good effect on mild to moderate Alzheimer's disease (AD). In recent years, there were a lot of studies on the mechanism of donepezil. This paper mainly introduces the
Xin-xin LI, Yun-yun ZHANG, Bin WANG
doaj
Angewandte Chemie International Edition, EarlyView.This review highlights mechanochemical strategies for the late‐stage modification of active pharmaceutical ingredients (APIs), providing a valuable resource for selecting substrates to evaluate the pharmaceutical potential of novel and existing (mechano)chemical protocols.
Johanna Templ, Lars Borchardt
wiley +1 more source
Recent advances in pharmaceutical sciences VII [PDF]
, 2017 The E-book series Recent Advances in Pharmaceutical Sciences reports research contributions from different areas of the multidisciplinary field of Pharmaceutical Sciences.
Feliu José, Carlos +2 more
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Angewandte Chemie International Edition, EarlyView.We present a nanodroplet array platform that integrates solid‐phase synthesis, MALDI‐MS analysis, and cell‐based screening. Using nanoliter droplets, we synthesized and tested 325 potential MEK inhibitors and identified 46 active compounds. This miniaturized approach combines chemistry and biology on a single chip, reducing time, cost, and material use
Maximilian Seifermann +10 more
wiley +1 more source
Novel Approaches For The Synthesis Of Amino Acids And Piperidines, Including Asymmetric Strategies [PDF]
, 2012 Chapter I deals with novel approaches for α-amino acids. This chapter has been divided into three sections. Section A describes the synthesis of α-amino acids via the Beckmann rearrangement of carboxyl-protected β-keto acid oximes.
Vippila, Mohana Rao
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