Results 171 to 180 of about 24,641 (321)

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

British Journal of Pharmacology, EarlyView.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert, Chantal Fitterer, Sylvain Hugel, Mila Jesic, Yannick Goumon, Virgine Andry, Severine Schneider, Francois Daubeuf, Abdelfattah Faouzi, Stephane Doridot, Susruta Majumdar, Frederic Bihel, Martine Schmitt, Dominique Massotte   +13 more
wiley   +1 more source

Cooperative Brønsted Acid and Photo-Promoted Stereoselective Synthesis of Substituted Piperidones. [PDF]

Angew Chem Int Ed Engl
Peng Q, Mukherjee P, Suresh A, Hwang M, Gutierrez O, Scheidt KA.   +5 more
europepmc   +1 more source

The importin‐alpha superfamily engages in ethylene signaling by shuttling ETHYLENE INSENSITIVE 2 from the endoplasmic reticulum to the nucleus

The FEBS Journal, EarlyView.
The plant hormone ethylene regulates plant growth, ripening, senescence, and stress responses. The hormonal signal transmission, from receptors at the ER membrane to the transcriptional regulators in the nucleus, is still not completely understood.
Fabian Wynen, Jan Eric Maika, Raphael Josef Eberle, Nina Jahnke, Marcel Wiermer, Laura Hartmann, Rüdiger Simon, Georg Groth   +7 more
wiley   +1 more source

Tertiary Piperidines [PDF]

Chemical & Engineering News Archive, 1976
openaire   +3 more sources

Predictors of a Gabapentinoid–Loop‐Diuretic Prescribing Cascade in U.S. Nursing Home Residents

Journal of the American Geriatrics Society, EarlyView.
Among 23,544 older adult long‐stay nursing home residents who initiated a gabapentinoid in the nursing home (2016–2022), 4.2% experienced a loop diuretic prescribing cascade within 90 days. Predictors of the prescribing cascade included older age, higher medication burden (≥ 15 medications), current receipt of non‐loop diuretics, and titration of ...
Kaleen N. Hayes, Emmanuelle Belanger, Arman Oganisian, Richa Joshi, Xiao (Joyce) Wang, Lexie R. Grove, Kelsey L. Corcoran, Andrew R. Zullo   +7 more
wiley   +1 more source

Selective <i>endo</i>-Cyclic α-Functionalization of Saturated <i>N</i>-Alkyl Piperidines. [PDF]

J Org Chem
Phillips RC, Chu JCK, Rafaniello AA, Gaunt MJ.   +3 more
europepmc   +1 more source

Renin inhibition by substituted piperidines: A novel paradigm for the inhibition of monomeric aspartic proteinases?

, 1999
Christian Oefner, Alfred Binggeli, Volker Breu, Daniel Bur, J-P. Clozel, A. D’Arcy, A Dorn, Walter Fischli, Fiona Grüninger, Rolf Güller, Georges Hirth, Hans-Peter Märki, Sarah Mathews, Marcel Müller, RG Ridley, H Stadier, E. VIEIRA, M Wilhelm, FK Winkler, Wolfgang Wostl   +19 more
openalex   +1 more source

Frontispiece: Efficient Synthesis of Dimeric Oxazoles, Piperidines and Tetrahydroisoquinolines from N‐Substituted 2‐Oxazolones [PDF]

, 2016
Yun He, Piyush Agarwal, I. N. Chaithanya Kiran, Ruocheng Yu, Bei Cao, Cheng Zou, Xinghua Zhou, Huacheng Xu, Biao Xu, Lei Zhu, Yu Lan, K. C. Nicolaou   +11 more
openalex   +1 more source

A Retrospective Chart Review of the Prevalence, Characteristics, and Discharge Destinations of Patients Hospitalized as “Social Admissions”

Journal of the American Geriatrics Society, EarlyView.
Overview of study.
Jasmine Mah, Lucy Eum, Lindsey Puddicombe, Christie Stilwell, Karen Nicholls, Hamish Frayne, Clara Long, Kristin Ko, Victoria Howatt, Margaret Man‐Ger Sun, Lynnea Lobert, Gali Latariya, Katalin Koller, Susan Freter, Maia von Maltzahn, Kenneth Rockwood, Samuel D. Searle, Melissa K. Andrew   +17 more
wiley   +1 more source

Regiodivergent α- and β-Functionalization of Saturated <i>N</i>-Heterocycles by Photocatalytic Oxidation. [PDF]

J Am Chem Soc
Rackl JW, Müller AF, Profyllidou A, Wennemers H.   +3 more
europepmc   +1 more source