Results 171 to 180 of about 40,506 (345)

Adducts of Piperidine, Piperazine, Methylpiperazine, and Morpholine with Bis(β-Ketoenolates) of Nickel(II) [PDF]

, 1972
G. MARCOTRIGIANO, Raffaele Battistuzzi, Gian Carlo Pellacani   +2 more
openalex   +1 more source

Novel Potent and Selective Dopamine D4 Receptor Piperidine Antagonists as Potential Alternatives for the Treatment of Glioblastoma. [PDF]

Pharmaceuticals (Basel)
Matteucci F, Pavletić P, Bonifazi A, Garland R, Yano H, Amantini C, Zeppa L, Sabato E, Vistoli G, Mammoli V, Cappellacci L, Del Bello F, Giorgioni G, Petrelli R, Piergentili A, Quaglia W, Piergentili A.   +16 more
europepmc   +1 more source

Further Structure‐Activity Relationship of G Protein‐Gated Inwardly Rectifying Potassium Channels 1/2 Activators: Synthesis and Biological Characterization of In Vitro Tool Compounds

ChemMedChem, EarlyView.
Work presented here details the design and characterize novel G protein‐gated inwardly rectifying potassium channels (GIRK)1/2 activators. A new 4,4‐difluorocyclohexylpyrazole have been identified that confers improved potency and selectivity for GIRK1/2 versus GIRK1/4.
Sumaiya Nahid, Fahad Imtiaz Rahman, Yu Du, Brittany D. Spitznagel, Sandeep K. Singh, Yashpal S. Chhonker, Daryl J. Murry, C. David Weaver, Corey R. Hopkins   +8 more
wiley   +1 more source

Driving tert-butyl axial: the surprising cyclopropyl effect. [PDF]

Chem Sci
Izzotti AR, Gleason JL.
europepmc   +1 more source

Chiron approaches to polyhydroxylated piperidines: promising glycosidase inhibitors

ARKIVOC, 2002
Dilip D. Dhavale, Vijaya N. Desai, Nabendu N. Saha, Jayant N. Tilekar   +3 more
doaj   +1 more source

Novel Para‐Phenylenediamine‐Based Derivatives as Receptor Tyrosine Kinase‐like Orphan Receptor 1 (ROR1) Inhibitors: An In Vitro Preliminary Characterization

ChemMedChem, EarlyView.
ROR1 represents a promising target for the development of novel antiproliferative compounds, giving its high expression in different cancer cell lines. The present study describes the workflow leading to the design, synthesis, and characterization of a series of para‐phenylenediamine‐based compounds able to interact with the target kinase, inhibiting ...
Gerardina Smaldone, Maria Rosaria Miranda, Francesca Di Matteo, Valeria Napolitano, Michela Aliberti, Simona Musella, Veronica Di Sarno, Gianluigi Lauro, Giuseppe Bifulco, Giacomo Pepe, Giovanna Aquino, Mario Felice Tecce, Isabel Maria Gomez‐Monterrey, Pietro Campiglia, Carmine Ostacolo, Alessia Bertamino, Vincenzo Vestuto, Tania Ciaglia   +17 more
wiley   +1 more source

2-{<i>N</i>-[ω-(1-Benzylpiperidin-4-yl)alkyl]amino}-6-[(prop-2-yn-1-yl)amino]pyridine-3,5-dicarbonitriles Showing High Affinity for σ_1/2 Receptors. [PDF]

Int J Mol Sci
Deuther-Conrad W, Schepmann D, Iriepa I, López-Muñoz F, Chioua M, Wünsch B, Samadi A, Marco-Contelles J.   +7 more
europepmc   +1 more source

Intracellular and Extracellular Efficacy of Homoisoflavone Derivatives Against Mycobacterium tuberculosis: Progress Toward Novel Antitubercular Agents

ChemMedChem, Accepted Article.
Tuberculosis (TB) is the leading cause of death among infectious diseases, and new studies focusing new anti‐TB drugs are urgent due to the emergence of drug‐resistant strains. In this regard, homoisoflavones, an underexplored subgroup of flavonoids, were explored for their potential as anti‐TB agents.
Sanderson D. Calixto, Juliane S. Falcão, Stella S. Antunes, Marlon H. Araujo, Alexandre L. B. Cunha, David R. Martins, Sarah M. R. Nascimento, Thatiana L. B. V. Simão, Elena B. Lasunskaia, Nelilma C. Romeiro, Paulo R. R. Costa, Michelle Muzitano, Guilherme S. Caleffi   +12 more
wiley   +1 more source

FOR PIPERIDINES, CONTACT REILY [PDF]

, 1971

openalex   +1 more source

Synthesis and biological characterization of 4,4‐difluoro‐3(phenoxymethyl)piperidine scaffold as dopamine 4 receptor (D4R) antagonist in vitro tool compounds

ChemMedChem, Accepted Article.
We report the discovery and characterization of a novel series of 4,4‐difluoropiperidine etherbased dopamine D4 receptor antagonists. Structure‐activity relationship studies led to the identification of compound 14a, which displays exceptional binding affinity for the D4 receptor (Ki = 0.3 nM) and remarkable selectivity over other dopamine receptor ...
Saeedeh Saeedi, Sumaiya Nahid, Anish Vadukoot, Corey R Hopkins   +3 more
wiley   +1 more source