Results 171 to 180 of about 23,915 (334)

Photocatalytic Decarboxylative Functionalization of Bioactive, Naturally Occurring, and Fatty Acids Via Gem‐Borylsilyl Alkene

open access: yesChemistryEurope, EarlyView.
A photocatalytic, late‐stage decarboxylative functionalization of carboxylic acids using gem‐borylsilyl alkenes is described. This transformation enables the direct decarboxylative /radical addition of bioactive, naturally occurring, and fatty acids to gem‐B,Si alkenes, delivering synthetically valuable alkylboron,silayl under mild, visible‐light ...
Nadim Eghbarieh, Ahmad Masarwa
wiley   +1 more source

Sequential Carboborylation–Suzuki Coupling of α,β‐Unsaturated Tosylhydrazones: A Dual CC Bond‐Forming Strategy for Molecular Diversification

open access: yesChemistryEurope, EarlyView.
Structural diversity can be generated from α,β‐unsaturated carbonyls via N‐tosylhydrazones through a one‐pot‐three‐component photochemically promoted carboborylation/allylic Suzuki sequence. The wide availability and scope regarding each of three reaction partners: carbonyls, alkylboronic acids, and aryl halides, and the functionalities available in ...
Álvaro Valdés‐Maqueda   +2 more
wiley   +1 more source

Advances in Enaminomaleimides Chemistry: Synthesis, Chemical Applications, and Perspectives

open access: yesChemistryEurope, EarlyView.
Enaminomaleimides are versatile building blocks for the construction of functionalized heterocycles. Their unique nucleophilic character, contrasting with the classical electrophilic nature of maleimides, enables diverse synthetic applications, showing promising potential in both materials science and medicinal chemistry.
Adrián López‐Francés   +5 more
wiley   +1 more source

Bistable and Water‐Operable Hemiindigo Photoswitches Allow Optical Control of Acetylcholinesterase Activity with Visible Light

open access: yesChemistryEurope, EarlyView.
We report the first hemiindigo‐based photopharmacological agents, acting as nanomolar human acetylcholinesterase inhibitors with isomer‐specific bioactivity. These compounds combine efficient and fully reversible photoswitching in aqueous solution using visible light, with a very high stability of the metastable isomer in water, especially for N‐methyl
Leticia M. Lazinski   +6 more
wiley   +1 more source

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