Results 181 to 190 of about 23,915 (334)

Efficient Synthesis of Cyclopropane-Fused Heterocycles with Bromoethylsulfonium Salt [PDF]

, 2013
Aggarwal, Artamonov, Basavaiah, Boger, Bornholdt, Catalan-Munoz, Chaplinski, de Carne-Carnavalet, Donohoe, Eckert, Feng, Fritz, Fritz, Fritz, Galeazzi, Gensini, Gomi, Gosselck, Gosselck, Greene, Hanessian, Hansch, Huang, Iwabuchi, Jeffery, Kamimura, Kasai, Kim, Kim, Kokotos, Krieter, Krow, Kulinkovich, Lin, Maeda, Mao, McGarrigle, McGarrigle, Meldrum, Miller, Namba, Nelson, Njoroge, Norris, Nunez, Ohno, Renslo, Sabbatini, Sasaki, Sattigeri, Schoepp, Shi, Takahashi, Tverezovsky, Unthank, Unthank, Van Zijl, Wiberg, Wirth, Xie, Xie, Xu, Yamanaka, Yar, Yar, Yar, Zhang   +66 more
core   +2 more sources

Water‐Soluble Peptoids with Two Different Binding Sites for Strong ATP Chelation

Chemistry – A European Journal, Volume 31, Issue 51, September 11, 2025.
ATP is key for activating enzymes associated with cancer. A potential therapeutic approach is strong binding of ATP, making it unavailable to enzymes. The water‐soluble peptoid P1‐TB incorporates two synergistic binding sites for ATP: terpyridine‐Zn²⁺ and 4‐CPBA that bind ATP's phosphate and diol groups, respectively, and exhibits an exceptional Kᴅ‐ATP
Nicole Vorobyov, Galia Maayan
wiley   +1 more source

PHARMACOLOGICAL STUDIES OF 1-PHENACYL-2, 3-DIMETHYL-3-(3-HYDROXYPHENYL) PIPERIDINE HYDROCHLORIDE (TA-306), AN ANALGESIC AND ANTITUSSIVE AGENT

, 1968
Goro Hayashi, SEIIGHI NURIMOTO, YUZO NOGUGHI, Hiroshi Kugita, Yoshio KOWA   +4 more
openalex   +1 more source

Directing Effects of Silyl and Germyl Groups in Transition‐Metal‐Catalyzed Allylic Substitution

Chemistry – A European Journal, EarlyView.
Despite the maturity of transition‐metal‐catalyzed allylic substitution, unsymmetrical 1,3‐disubstituted electrophiles remain underexplored due to inherent regioselectivity challenges. This Concept highlights the strategic use of silyl and germyl groups to overcome this limitation, steering bond formation with high regiocontrol and serving as linchpins
Daniel Brösamlen, Martin Oestreich
wiley   +1 more source

Regiodivergent α- and β-Functionalization of Saturated <i>N</i>-Heterocycles by Photocatalytic Oxidation. [PDF]

J Am Chem Soc
Rackl JW, Müller AF, Profyllidou A, Wennemers H.   +3 more
europepmc   +1 more source

N-(N4-Aryl-N1 piperazinylmethyl)-4-(4'-methoxyphenyl)- piperidine-2,6-diones : CNS Depressants [PDF]

, 1978
S. D. SAMANT, R. A. KULKARNI
openalex   +1 more source

4‐Dimethylamino‐1,8‐Naphthalimide as a Fluorescence Signal Amplification for Site Selective and in Situ Probing of the Hydroxyl Radical

Chemistry – A European Journal, EarlyView.
4‐dimethylamino‐1,8‐naphthalimide (NMI) as new fluorescence‐responsive tool for HO• detection. Proof of concept illustrating that NMI selectively probes HO• produced by Cu‐bound to Aβ16 in presence of scavengers with an amplified response. Abstract Overproduction of reactive oxygen species (ROS) is involved in several diseases.
Yelisetty Venkata Suseela, Sabyasachi Mandal, Denis Jacquemin, Thimmaiah Govindaraju, Peter Faller   +4 more
wiley   +1 more source

Transaminase-Triggered Cascades for the Synthesis and Dynamic Kinetic Resolution of Chiral N-Heterocycles. [PDF]

Angew Chem Int Ed Engl
O'Connell A, Haarr MB, Ryan J, Xu X, Martin A, Smith SN, Elghobashi-Meinhardt N, Fleming P, Maciá B, Caprio V, O'Reilly E.   +10 more
europepmc   +1 more source

Potent, Selective, and Drug‐like G Protein‐coupled Receptor Kinase 5 and 6 Inhibitors: Design, Synthesis, and X‐ray Structural Studies

ChemMedChem, Accepted Article.
We report here the design, synthesis, and evaluation of small molecules, drug‐like G protein‐coupled receptor kinase 5 (GRK5) inhibitors. GRK5 has become an important drug development target against heart failure and cancer. GRK6, a close homolog of GRK5, is considered as a possible therapeutic target for multiple myeloma.
Arun K Ghosh, Ranjith Kumar Gadi, Yueyi Chen, Sandali Piladuwa Gamage, Kathryn McCauley, John J. G. Tesmer   +5 more
wiley   +1 more source

Syntheses of N-(Chlorobenzoylaminoalkyl)piperidines and N-(Chlorothiobenzoylaminoalkyl)piperidines

, 1969
去来川 覚三, 広瀬 拓治, 伏崎 弥三郎   +2 more
openalex   +2 more sources