Results 191 to 200 of about 23,915 (334)

Carbon-13 Magnetic Resonance: the Stereochemistry of Pharmacologically Active 1,2,5-Trimethyl-4-phenyl-piperidine Derivatives [PDF]

, 1973
Alan J. Jones, C. P. Beeman, A. F. Casy, Keith M. McErlane   +3 more
openalex   +1 more source

Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry

ChemMedChem, EarlyView.
This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali, Samet Poyraz, Samet Belveren, Senanur Taş, Mehmet Ali Tamer, Naciye Yaktubay Döndaş, H. Ali Döndaş, Jose Miguel Sansano   +7 more
wiley   +1 more source

Synthesis and Cardiovascular Activity of 3-(3, 4-Dimethoxy or Dihydroxyphenyl)piperidine Derivatives

, 1967
MUNEYOSHI IKEZAKI, Masanori Sato, Hiroshi Kugita   +2 more
openalex   +2 more sources

The Treatment of Phthisis by Guaiacolate of Piperidine [PDF]

BMJ, 1897
Arnold Chaplin, F. W. Tunnicliffe
openaire   +3 more sources

Development of Keap1‐Nrf2 Protein–Protein Interaction Inhibitor Activating Intracellular Nrf2 Based on the Naphthalene‐2‐acetamide Scaffold, and its Anti‐Inflammatory Effects

ChemMedChem, EarlyView.
Pyrrolidine‐type naphthalene‐2‐acetamide compound 5i inhibits Kelch‐like ECH‐associated protein 1 (Keap1)‐nuclear factor erythroid 2‐related factor 2 (Nrf2) protein–protein interaction by binding to the Keap1‐DC domain; it subsequently activates intracellular Nrf2 and induces Nrf2‐target genes.
Daisuke Yasuda, Kai Toyoshima, Koujin Kojima, Hanako Ishida, Kazuma Kaitoh, Riyo Imamura, Kayoko Kanamitsu, Hirotatsu Kojima, Megumi Funakoshi‐Tago, Masanori Osawa, Tomoyuki Ohe, Tomoya Hirano   +11 more
wiley   +1 more source

Synthesis of Chiral Saturated Heterocycles Bearing Quaternary Centers via Enantioselective β-C(sp³)-H Activation of Lactams. [PDF]

J Am Chem Soc
Lu P, Burgenson WR, Simmons BJ, Liu S, Yeung KS, Qiao JX, Yu JQ.   +6 more
europepmc   +1 more source

Asymmetric Electrophilic alpha-Amidoalkylation 6 [PDF]

, 1989
Praschak, Ilona, Wanner, Klaus Th.
core   +1 more source

Synthesis of Urea‐Containing Derivatives and their Application as Potential Anti‐Methicillin‐Resistant Staphylococcus Aureus Agents

ChemMedChem, EarlyView.
A series of propylureido amides against methicillin‐resistant Staphylococcus aureus (MRSA) activity was prepared. The design involved replacing other hydrogen bond donors reported in FabI inhibitors with a urea moiety, while maintaining other pharmacophoric features.
Jorge A. González‐Cruz, Gerardo González‐Gallardo, J. Ricardo Pérez‐Velázquez, Carlos D. García‐Mejía, José Manuel Guevara‐Vela, Jesús A. Oria‐Hernández, Adriana Castillo‐Villanueva, Tomás Rinza‐Rocha, Eduardo Hernández‐Vázquez   +8 more
wiley   +1 more source

Dearomative spirocyclization of ynamides. [PDF]

Chem Sci
Agbaria M, Egbaria N, Nairoukh Z.
europepmc   +1 more source

FOR PIPERIDINES, CONTACT REILY [PDF]

, 1971

openalex   +1 more source