Results 191 to 200 of about 40,506 (345)

Determination of Diketopiperazine Formation During the Solid‐Phase Synthesis of C‐Terminal Acid Peptides

open access: yesChemistry–Methods, EarlyView.
Diketopiperazine formation (DKP) is one of the most serious side reactions during peptide synthesis. An accurate method to determine the DKP formation in peptide synthesis on Wang resin is reported. Furthermore, the strategies to minimize this side reaction and side products lacking C‐terminal amino acids are described. Diketopiperazine formation (DKP)
Mani Kaushal   +7 more
wiley   +1 more source

Bioequivalence of a Donepezil/Memantine 10/20 mg Fixed‐Dose Combination Versus Single‐Component Tablets in Healthy Korean Males

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract A fixed‐dose combination (FDC) tablet formulation of donepezil/memantine (10/20 mg) was developed to improve medication compliance in patients with Alzheimer's disease (AD). This study compared the pharmacokinetic (PK) characteristics and safety profiles of an FDC formulation (donepezil/memantine [10/20 mg]) and single components (SCs) of ...
Minkyu Choi   +7 more
wiley   +1 more source

Open‐Chain Tetrapyrroles Meet Metal Ions in the Functional Molecular Material Science

open access: yesChemPlusChem, EarlyView.
Open‐chain tetrapyrroles, synthesized via oxidative cleavage and condensation, offer greater structural flexibility than cyclic counterparts like porphyrins. Their tunable electronic and geometric properties through metalation enable applications in bioimaging, therapies, ion sensing, chiroptical materials, and spintronic devices, making them valuable ...
Aninda Ghosh   +3 more
wiley   +1 more source

Blue‐Light‐Driven Iron‐Catalyzed Desulfurization of Thioamides under Hydrosilylation Conditions

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
Insert text for Table of Contents here. This contribution described the first general iron‐catalyzed hydrogenative desulfurization of thioamides under hydrosilylation, the transformation being driven by blue light irradiation at ambient conditions. Well‐defined Fe(IMes)(CO)4 catalyst was used in the presence of phenylsilane under ambient conditions to ...
Qingxin Zhang, Christophe Darcel
wiley   +1 more source

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