Results 61 to 70 of about 1,197 (187)
Multiple Targeting Approaches on Histamine H3 Receptor Antagonists
Frontiers in Neuroscience, 2016 With the very recent market approval of pitolisant (Wakix®), the interest in clinical applications of novel multifunctional histamine H3 receptor antagonists has clearly increased. Since histamine H3 receptor antagonists in clinical development have been
Mohammad eKhanfar +5 more
doaj +1 more source
H_3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice [PDF]
, 2016 The use of atypical antipsychotic drugs like olanzapine is associated with side effects such as sedation and depression-like symptoms, especially during the initial period of the use.
Bednarski, Marek +9 more
core +1 more source
Narcolepsy and rapid eye movement sleep
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini +4 more
wiley +1 more source
Sleep Reactivity Amplifies the Impact of Pre‐Sleep Cognitive Arousal on Sleep Disturbances
Journal of Sleep Research, EarlyView.This study investigates how sleep reactivity moderates the ‘stress‐pre‐sleep arousal‐sleep’ pathway in university students. At the within‐individual level, both high and low sleep‐reactive groups showed increased pre‐sleep cognitive arousal and sleep disruptions in response to elevated daily stress.
Noof Abdullah Saad Shaif +5 more
wiley +1 more source
Histaminergic neurotransmission in aging and Alzheimer's disease: A review of therapeutic opportunities and gaps [PDF]
, 2023 IntroductionAlzheimer's disease (AD) is a progressive neurodegenerative disorderfeaturing a brain accumulation of extracellular β-amyloidplaques (Aβ) and intracellular neurofibrillary tautangles (NFTs).
Grinberg, Lea T +2 more
core +1 more source
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract Neuromodulatory subcortical systems (NSSs) are uniquely susceptible to dementia‐related pathology, leading to frequent molecular and behavioral impairments associated with altered function of these nuclei. Some of these systems display clear sex‐specific cytoarchitecture and signaling leading to distinct physiology and behavioral outputs in ...
Rosaria J. Rae +53 more
wiley +1 more source
Protein Science, Volume 35, Issue 1, January 2026.Abstract The histamine H3 receptor (H3R) is a class A G protein‐coupled receptor (GPCR) that regulates neurotransmitter release in the central nervous system. Although structures of H3R in both inactive and active states have been elucidated, the functional roles of specific residues remain unclear.
Ami Nakajima +6 more
wiley +1 more source
RSC AdvancesA simple and highly sensitive method was devised to detect and measure minute concentrations of diethyl sulfate (DES), a potential genotoxic impurity found in the active pharmaceutical ingredients of pitolisant hydrochloride.
Santosh Bhagwat +5 more
semanticscholar +1 more source
Sleep Medicine, 2023 STUDY OBJECTIVES Modafinil is a common treatment for excessive daytime sleepiness (EDS) in narcolepsy. The long-term use of modafinil can lead to tolerance with the loss of efficacy and the continuous increase of its dose.
Y. Winter +6 more
semanticscholar +1 more source
Narcolepsy: Pathophysiology, Diagnosis, Management, and Future Directions, a Narrative Review
Brain and Behavior, Volume 15, Issue 12, December 2025.This visual summary outlines the pathophysiology of narcolepsy, driven by hypocretin loss, and details its clinical diagnosis, current management strategies, and the shift toward future disease‐modifying therapies like orexin agonists and immunomodulation.
Natasha Elaine Hastings +12 more
wiley +1 more source