The septin cytoskeleton is required for plasma membrane repair [PDF]
EMBO Reports, 2023 Plasma membrane repair is a fundamental homeostatic process of eukaryotic cells. Here, we report a new function for the conserved cytoskeletal proteins known as septins in the repair of cells perforated by pore-forming toxins or mechanical disruption ...
M Isabella Prislusky +9 more
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Leveraging Plasma Membrane Repair Therapeutics for Treating Neurodegenerative Diseases [PDF]
Cells, 2023 Plasma membrane repair is an essential cellular mechanism that reseals membrane disruptions after a variety of insults, and compromised repair capacity can contribute to the progression of many diseases.
Hannah R. Bulgart +2 more
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Annexin A6 mediates calcium-dependent exosome secretion during plasma membrane repair [PDF]
eLife, 2023 Exosomes are an extracellular vesicle (EV) subtype that is secreted upon the fusion of multivesicular bodies (MVBs) with the plasma membrane. Exosomes may participate in intercellular communication and have utility as disease biomarkers; however, little ...
Justin Krish Williams +3 more
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Timescale of hole closure during plasma membrane repair estimated by calcium imaging and numerical modeling [PDF]
Scientific Reports, 2021 Plasma membrane repair is essential for eukaryotic cell life and is triggered by the influx of calcium through membrane wounds. Repair consists of sequential steps, with closure of the membrane hole being the key event that allows the cell to recover ...
Martin Berg Klenow +3 more
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Plasma Membrane Wounding and Repair Assays for Eukaryotic Cells
Bio-Protocol, 2022 Damage to the plasma membrane and loss of membrane integrity are detrimental to eukaryotic cells. It is, therefore, essential that cells possess an efficient membrane repair system to survive.
Stine Sønder +4 more
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Plasma Membrane Repair in Health and Disease. [PDF]
Curr Top Membr, 2016 Since an intact membrane is required for normal cellular homeostasis, membrane repair is essential for cell survival. Human genetic studies, combined with the development of novel animal models and refinement of techniques to study cellular injury, have now uncovered series of repair proteins highly relevant for human health.
Demonbreun AR, McNally EM.
europepmc +4 more sources
Endoplasmic reticulum maintains ion homeostasis required for plasma membrane repair. [PDF]
J Cell Biol, 2021 Of the many crucial functions of the ER, homeostasis of physiological calcium increase is critical for signaling. Plasma membrane (PM) injury causes a pathological calcium influx. Here, we show that the ER helps clear this surge in cytoplasmic calcium through an ER-resident calcium pump, SERCA, and a calcium-activated ion channel, Anoctamin 5 (ANO5 ...
Chandra G +6 more
europepmc +3 more sources
Triggered Golgi membrane enrichment promotes PtdIns(4,5)P2 generation for plasma membrane repair. [PDF]
J Cell Biol, 2023 The maintenance of plasma membrane integrity and a capacity for efficiently repairing damaged membranes are essential for cell survival. Large-scale wounding depletes various membrane components at the wound sites, including phosphatidylinositols, yet little is known about how phosphatidylinositols are generated after depletion.
Meng X, Wijaya CS, Shao Q, Xu S.
europepmc +3 more sources
Plasma Membrane Repair Is Regulated Extracellularly by Proteases Released from Lysosomes. [PDF]
PLoS ONE, 2016 Eukaryotic cells rapidly repair wounds on their plasma membrane. Resealing is Ca(2+)-dependent, and involves exocytosis of lysosomes followed by massive endocytosis.
Thiago Castro-Gomes +3 more
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Large-scale identification of plasma membrane repair proteins revealed spatiotemporal cellular responses to plasma membrane damage [PDF]
eLifeDamage to the plasma membrane (PM) is common in all types of cells. PM repair processes, including exocytosis and endocytosis, are not mutually exclusive; rather, they collaborate to repair the wound. However, the temporal coordination between the repair
Yuta Yamazaki, Keiko Kono
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