The septin cytoskeleton is required for plasma membrane repair [PDF]
EMBO ReportsPlasma membrane repair is a fundamental homeostatic process of eukaryotic cells. Here, we report a new function for the conserved cytoskeletal proteins known as septins in the repair of cells perforated by pore-forming toxins or mechanical disruption ...
M Isabella Prislusky +9 more
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LAMP-2 absence interferes with plasma membrane repair and decreases T. cruzi host cell invasion. [PDF]
PLoS Neglected Tropical Diseases, 2017 Trypanosoma cruzi enters host cells by subverting the mechanism of cell membrane repair. In this process, the parasite induces small injuries in the host cell membrane leading to calcium entry and lysosomal exocytosis, which are followed by compensatory ...
Natália Fernanda Couto +9 more
doaj +4 more sources
Annexin A6 mediates calcium-dependent exosome secretion during plasma membrane repair [PDF]
eLife, 2023 Exosomes are an extracellular vesicle (EV) subtype that is secreted upon the fusion of multivesicular bodies (MVBs) with the plasma membrane. Exosomes may participate in intercellular communication and have utility as disease biomarkers; however, little ...
Justin Krish Williams +3 more
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Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair [PDF]
Cells, 2020 The plasma membrane surrounds every single cell and essentially shapes cell life by separating the interior from the external environment. Thus, maintenance of cell membrane integrity is essential to prevent death caused by disruption of the plasma ...
Poul Martin Bendix +16 more
doaj +2 more sources
Leveraging Plasma Membrane Repair Therapeutics for Treating Neurodegenerative Diseases [PDF]
Cells, 2023 Plasma membrane repair is an essential cellular mechanism that reseals membrane disruptions after a variety of insults, and compromised repair capacity can contribute to the progression of many diseases.
Hannah R. Bulgart +2 more
doaj +2 more sources
Timescale of hole closure during plasma membrane repair estimated by calcium imaging and numerical modeling [PDF]
Scientific Reports, 2021 Plasma membrane repair is essential for eukaryotic cell life and is triggered by the influx of calcium through membrane wounds. Repair consists of sequential steps, with closure of the membrane hole being the key event that allows the cell to recover ...
Martin Berg Klenow +3 more
doaj +2 more sources
Plasma Membrane Wounding and Repair Assays for Eukaryotic Cells
Bio-Protocol, 2022 Damage to the plasma membrane and loss of membrane integrity are detrimental to eukaryotic cells. It is, therefore, essential that cells possess an efficient membrane repair system to survive.
Stine Sønder +4 more
doaj +3 more sources
Endoplasmic reticulum maintains ion homeostasis required for plasma membrane repair. [PDF]
J Cell Biol, 2021 Chandra G +6 more
europepmc +3 more sources
Plasma Membrane Repair Is Regulated Extracellularly by Proteases Released from Lysosomes. [PDF]
PLoS ONE, 2016 Eukaryotic cells rapidly repair wounds on their plasma membrane. Resealing is Ca(2+)-dependent, and involves exocytosis of lysosomes followed by massive endocytosis.
Thiago Castro-Gomes +3 more
doaj +2 more sources
Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins [PDF]
Toxins, 2018 Permeabilization of the plasma membrane represents an important threat for any cell, since it compromises its viability by disrupting cell homeostasis.
Asier Etxaniz +3 more
doaj +4 more sources