Results 11 to 20 of about 165,729 (227)
Phosphatidylserine regulates plasma membrane repair through tetraspanin-enriched macrodomains. [PDF]
J Cell BiolThe integrity of the plasma membrane is critical to cell function and survival. Cells have developed multiple mechanisms to repair damaged plasma membranes. A key process during plasma membrane repair is to limit the size of the damage, which is facilitated by the presence of tetraspanin-enriched rings surrounding damage sites.
Li YE +10 more
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Cellular mechanisms and signals that coordinate plasma membrane repair. [PDF]
Cell Mol Life Sci, 2018 Plasma membrane forms the barrier between the cytoplasm and the environment. Cells constantly and selectively transport molecules across their plasma membrane without disrupting it. Any disruption in the plasma membrane compromises its selective permeability and is lethal, if not rapidly repaired.
Horn A, Jaiswal JK.
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Damage control: cellular mechanisms of plasma membrane repair. [PDF]
Trends Cell Biol, 2014 When wounded, eukaryotic cells reseal in a few seconds. Ca(2+) influx induces exocytosis of lysosomes, a process previously thought to promote repair by 'patching' wounds. New evidence suggests that resealing involves direct wound removal. Exocytosis of lysosomal acid sphingomyelinase (ASM) triggers endocytosis of lesions followed by intracellular ...
Andrews NW, Almeida PE, Corrotte M.
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Structural and signaling role of lipids in plasma membrane repair. [PDF]
Curr Top Membr, 2019 The plasma membrane forms the physical barrier between the cytoplasm and extracellular space, allowing for biochemical reactions necessary for life to occur. Plasma membrane damage needs to be rapidly repaired to avoid cell death. This relies upon the coordinated action of the machinery that polarizes the repair response to the site of injury ...
Horn A, Jaiswal JK.
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Shape of the membrane neck around a hole during plasma membrane repair. [PDF]
Biophys JPlasma membrane damage and rupture occurs frequently in cells, and holes must be sealed rapidly to ensure homeostasis and cell survival. The membrane repair machinery is known to involve recruitment of curvature-inducing annexin proteins, but the connection between membrane remodeling and hole closure is poorly described.
Klenow MB +5 more
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LAMP-2 absence interferes with plasma membrane repair and decreases T. cruzi host cell invasion. [PDF]
PLoS Neglected Tropical Diseases, 2017 Trypanosoma cruzi enters host cells by subverting the mechanism of cell membrane repair. In this process, the parasite induces small injuries in the host cell membrane leading to calcium entry and lysosomal exocytosis, which are followed by compensatory ...
Natália Fernanda Couto +9 more
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Dysferlinopathy Fibroblasts Are Defective in Plasma Membrane Repair.
PLoS Curr, 2015 Dysferlin is a sarcolemmal protein that is defective in Miyoshi myopathy and limb-girdle muscular dystrophy type 2B, and is involved in sarcolemmal repair. Primary cultured myoblasts and myotubes established from patient muscle biopsies have been widely utilized to explore the molecular mechanism of dysferlinopathy.The purpose of this study was to ...
Matsuda C +4 more
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The antioxidant requirement for plasma membrane repair in skeletal muscle. [PDF]
Free Radic Biol Med, 2015 Vitamin E (VE) deficiency results in pronounced muscle weakness and atrophy but the cell biological mechanism of the pathology is unknown. We previously showed that VE supplementation promotes membrane repair in cultured cells and that oxidants potently inhibit repair. Here we provide three independent lines of evidence that VE is required for skeletal
Labazi M +7 more
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Plasma Membrane Repair: A Central Process for Maintaining Cellular Homeostasis.
Physiology (Bethesda), 2015 Plasma membrane repair is a conserved cellular response mediating active resealing of membrane disruptions to maintain homeostasis and prevent cell death and progression of multiple diseases. Cell membrane repair repurposes mechanisms from various cellular functions, including vesicle trafficking, exocytosis, and endocytosis, to mend the broken ...
Blazek AD, Paleo BJ, Weisleder N.
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Current Biology, 2018 Tissue wound repair has been studied extensively. It involves the coordinated activation of several intracellular and intercellular pathways, as well as remodeling from the sequential recruitment of different cell types to the wound site. There is, however, an equally important process that happens at the single cell level, when the integrity of the ...
Norma W, Andrews, Matthias, Corrotte
openaire +2 more sources