Results 21 to 30 of about 165,729 (227)

Plasma membrane integrity in health and disease: significance and therapeutic potential

Cell Discovery, 2021
Maintenance of plasma membrane integrity is essential for normal cell viability and function. Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of a torn plasma membrane.
Catarina Dias, Jesper Nylandsted
doaj   +1 more source

Lectin-based food poisoning: a new mechanism of protein toxicity. [PDF]

PLoS ONE, 2007
BACKGROUND: Ingestion of the lectins present in certain improperly cooked vegetables can result in acute GI tract distress, but the mechanism of toxicity is unknown.
Katsuya Miyake, Toru Tanaka, Paul L McNeil   +2 more
doaj   +1 more source

Annexin A2 Mediates Dysferlin Accumulation and Muscle Cell Membrane Repair

Cells, 2020
Muscle cell plasma membrane is frequently damaged by mechanical activity, and its repair requires the membrane protein dysferlin. We previously identified that, similar to dysferlin deficit, lack of annexin A2 (AnxA2) also impairs repair of skeletal ...
Daniel C. Bittel, Goutam Chandra, Laxmi M. S. Tirunagri, Arun B. Deora, Sushma Medikayala, Luana Scheffer, Aurelia Defour, Jyoti K. Jaiswal   +7 more
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Plasma membrane integrity: implications for health and disease

BMC Biology, 2021
Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience plasma membrane damage from a multitude of stressors in the extra- and intra-cellular environment.
Dustin A. Ammendolia, William M. Bement, John H. Brumell   +2 more
doaj   +1 more source

An Overview of Cell Membrane Perforation and Resealing Mechanisms for Localized Drug Delivery

Pharmaceutics, 2022
Localized and reversible plasma membrane disruption is a promising technique employed for the targeted deposition of exogenous therapeutic compounds for the treatment of disease.
Stephanie He, Davindra Singh, Brandon Helfield   +2 more
doaj   +1 more source

Critical Role of Lipid Scramblase TMEM16F in Phosphatidylserine Exposure and Repair of Plasma Membrane after Pore Formation

Cell Reports, 2020
Summary: Plasma membrane damage and cell death during processes such as necroptosis and apoptosis result from cues originating intracellularly. However, death caused by pore-forming agents, like bacterial toxins or complement, is due to direct external ...
Ning Wu, Vitalij Cernysiov, Dominique Davidson, Hua Song, Jianlong Tang, Shanshan Luo, Yan Lu, Jin Qian, Ivayla E. Gyurova, Stephen N. Waggoner, Vincent Quoc-Huy Trinh, Romain Cayrol, Ayumu Sugiura, Heidi M. McBride, Jean-François Daudelin, Nathalie Labrecque, André Veillette   +16 more
doaj   +1 more source

Deficient Sarcolemma Repair in ALS: A Novel Mechanism with Therapeutic Potential

Cells, 2022
The plasma membrane (sarcolemma) of skeletal muscle myofibers is susceptible to injury caused by physical and chemical stresses during normal daily movement and/or under disease conditions. These acute plasma membrane disruptions are normally compensated
Ang Li, Jianxun Yi, Xuejun Li, Li Dong, Lyle W. Ostrow, Jianjie Ma, Jingsong Zhou   +6 more
doaj   +1 more source

A pore-forming protein-induced surface-enhanced Raman spectroscopic strategy for dynamic tracing of cell membrane repair

iScience, 2021
Summary: The plasma membrane repair holds significance for maintaining cell survival and homeostasis. To achieve the sensitive visualization of membrane repair process for revealing its mechanism, this work designs a perforation-induced surface-enhanced ...
Yuanjiao Yang, Yunlong Chen, Jingxing Guo, Huipu Liu, Huangxian Ju   +4 more
doaj   +1 more source

Plasma membrane repairs by small GTPase Rab3a [PDF]

Journal of Cell Biology, 2016
Lysosomes fuse with the plasma membrane to help repair membrane lesions, but how they are positioned close to these lesions is not fully understood. Now, Encarnação et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511093) demonstrate that the lysosomal GTPase Rab3a and its effectors orchestrate lysosome positioning and plasma membrane ...
Camilla Raiborg, Harald Stenmark
openaire   +2 more sources

Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair

Cells, 2020
The plasma membrane surrounds every single cell and essentially shapes cell life by separating the interior from the external environment. Thus, maintenance of cell membrane integrity is essential to prevent death caused by disruption of the plasma ...
Poul Martin Bendix, Adam Cohen Simonsen, Christoffer D. Florentsen, Swantje Christin Häger, Anna Mularski, Ali Asghar Hakami Zanjani, Guillermo Moreno-Pescador, Martin Berg Klenow, Stine Lauritzen Sønder, Helena M. Danielsen, Mohammad Reza Arastoo, Anne Sofie Heitmann, Mayank Prakash Pandey, Frederik Wendelboe Lund, Catarina Dias, Himanshu Khandelia, Jesper Nylandsted   +16 more
doaj   +1 more source