Results 21 to 30 of about 312,836 (267)

Solving the secretory acid sphingomyelinase puzzle: Insights from lysosome-mediated parasite invasion and plasma membrane repair. [PDF]

Cell Microbiol, 2019
Andrews NW.
europepmc   +3 more sources

Plasma membrane integrity in health and disease: significance and therapeutic potential

Cell Discovery, 2021
Maintenance of plasma membrane integrity is essential for normal cell viability and function. Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of a torn plasma membrane.
Catarina Dias, Jesper Nylandsted
doaj   +1 more source

Lectin-based food poisoning: a new mechanism of protein toxicity. [PDF]

PLoS ONE, 2007
BACKGROUND: Ingestion of the lectins present in certain improperly cooked vegetables can result in acute GI tract distress, but the mechanism of toxicity is unknown.
Katsuya Miyake, Toru Tanaka, Paul L McNeil   +2 more
doaj   +1 more source

Annexin A2 Mediates Dysferlin Accumulation and Muscle Cell Membrane Repair

Cells, 2020
Muscle cell plasma membrane is frequently damaged by mechanical activity, and its repair requires the membrane protein dysferlin. We previously identified that, similar to dysferlin deficit, lack of annexin A2 (AnxA2) also impairs repair of skeletal ...
Daniel C. Bittel, Goutam Chandra, Laxmi M. S. Tirunagri, Arun B. Deora, Sushma Medikayala, Luana Scheffer, Aurelia Defour, Jyoti K. Jaiswal   +7 more
doaj   +1 more source

Plasma membrane integrity: implications for health and disease

BMC Biology, 2021
Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience plasma membrane damage from a multitude of stressors in the extra- and intra-cellular environment.
Dustin A. Ammendolia, William M. Bement, John H. Brumell   +2 more
doaj   +1 more source

An Overview of Cell Membrane Perforation and Resealing Mechanisms for Localized Drug Delivery

Pharmaceutics, 2022
Localized and reversible plasma membrane disruption is a promising technique employed for the targeted deposition of exogenous therapeutic compounds for the treatment of disease.
Stephanie He, Davindra Singh, Brandon Helfield   +2 more
doaj   +1 more source

Damage control: cellular mechanisms of plasma membrane repair. [PDF]

Trends Cell Biol, 2014
Andrews NW, Almeida PE, Corrotte M.
europepmc   +2 more sources

Deficient Sarcolemma Repair in ALS: A Novel Mechanism with Therapeutic Potential

Cells, 2022
The plasma membrane (sarcolemma) of skeletal muscle myofibers is susceptible to injury caused by physical and chemical stresses during normal daily movement and/or under disease conditions. These acute plasma membrane disruptions are normally compensated
Ang Li, Jianxun Yi, Xuejun Li, Li Dong, Lyle W. Ostrow, Jianjie Ma, Jingsong Zhou   +6 more
doaj   +1 more source

A pore-forming protein-induced surface-enhanced Raman spectroscopic strategy for dynamic tracing of cell membrane repair

iScience, 2021
Summary: The plasma membrane repair holds significance for maintaining cell survival and homeostasis. To achieve the sensitive visualization of membrane repair process for revealing its mechanism, this work designs a perforation-induced surface-enhanced ...
Yuanjiao Yang, Yunlong Chen, Jingxing Guo, Huipu Liu, Huangxian Ju   +4 more
doaj   +1 more source

The resealing factor S100A11 interacts with annexins and extended synaptotagmin-1 in the course of plasma membrane wound repair

Frontiers in Cell and Developmental Biology, 2022
After damage, cells repair their plasma membrane in an active process that is driven by Ca2+ entering through the wound. This triggers a range of Ca2+-regulated events such as the translocation of different Ca2+-binding proteins to the wound site which ...
Arsila P. K. Ashraf, Volker Gerke
doaj   +1 more source