Results 21 to 30 of about 2,379 (121)

Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair

Cells, 2020
The plasma membrane surrounds every single cell and essentially shapes cell life by separating the interior from the external environment. Thus, maintenance of cell membrane integrity is essential to prevent death caused by disruption of the plasma ...
Poul Martin Bendix, Adam Cohen Simonsen, Christoffer D. Florentsen, Swantje Christin Häger, Anna Mularski, Ali Asghar Hakami Zanjani, Guillermo Moreno-Pescador, Martin Berg Klenow, Stine Lauritzen Sønder, Helena M. Danielsen, Mohammad Reza Arastoo, Anne Sofie Heitmann, Mayank Prakash Pandey, Frederik Wendelboe Lund, Catarina Dias, Himanshu Khandelia, Jesper Nylandsted   +16 more
doaj   +1 more source

Surface-associated antigen induces permeabilization of primary mouse B-cells and lysosome exocytosis facilitating antigen uptake and presentation to T-cells

eLife, 2021
B-cell receptor (BCR)-mediated antigen internalization and presentation are essential for humoral memory immune responses. Antigen encountered by B-cells is often tightly associated with the surface of pathogens and/or antigen-presenting cells ...
Fernando Y Maeda, Jurriaan JH van Haaren, David B Langley, Daniel Christ, Norma W Andrews, Wenxia Song   +5 more
doaj   +1 more source

Caveolae internalization repairs wounded cells and muscle fibers

eLife, 2013
Rapid repair of plasma membrane wounds is critical for cellular survival. Muscle fibers are particularly susceptible to injury, and defective sarcolemma resealing causes muscular dystrophy. Caveolae accumulate in dystrophic muscle fibers and caveolin and
Matthias Corrotte, Patricia E Almeida, Christina Tam, Thiago Castro-Gomes, Maria Cecilia Fernandes, Bryan A Millis, Mauro Cortez, Heather Miller, Wenxia Song, Timothy K Maugel, Norma W Andrews   +10 more
doaj   +1 more source

Naturally occurring and tumor-associated variants of RNF167 promote lysosomal exocytosis and plasma membrane resealing

Journal of Cell Science, 2020
ABSTRACT Lysosomal exocytosis and resealing of damaged plasma membrane are essential for cellular homeostasis and tumor invasion. However, very little is known of the molecular machinery that regulates these physiological processes.
Sreeja V. Nair, Nikhil Dev Narendradev, Rithwik P. Nambiar, Rakesh Kumar, Srinivasa M. Srinivasula   +4 more
openaire   +2 more sources

Identification of Novel Antisense-Mediated Exon Skipping Targets in DYSF for Therapeutic Treatment of Dysferlinopathy

Molecular Therapy: Nucleic Acids, 2018
Dysferlinopathy is a progressive myopathy caused by mutations in the dysferlin (DYSF) gene. Dysferlin protein plays a major role in plasma-membrane resealing.
Joshua J.A. Lee, Rika Maruyama, William Duddy, Hidetoshi Sakurai, Toshifumi Yokota   +4 more
doaj   +1 more source

Into the breach: how cells cope with wounds [PDF]

Open Biology, 2018
Repair of wounds to individual cells is crucial for organisms to survive daily physiological or environmental stresses, as well as pathogen assaults, which disrupt the plasma membrane.
Mitsutoshi Nakamura, Andrew N. M. Dominguez, Jacob R. Decker, Alexander J. Hull, Jeffrey M. Verboon, Susan M. Parkhurst   +5 more
doaj   +1 more source

Shear-Responsive Red Blood Cell Carriers for Targeted Drug Delivery to Constricted Arteries. [PDF]

Small
Red blood cells are harnessed as mechanoresponsive carriers that exploit the elevated shear stress of stenotic arteries to transiently open membrane pores and release encapsulated therapeutics selectively at sites of arterial narrowing. By coupling vascular hemodynamics with RBC membrane mechanics, a hemodynamically activated platform for localized ...
Amar DN, Tuna R, Mekler T, Belenkovich M, Korneyev D, Kreinin Y, Glozman A, Sznitman J, Ingber DE, Liu ZL, Korin N.   +10 more
europepmc   +2 more sources

Naturally Occurring Shorter and Tumor-associated Mutant RNF167 Variants Facilitates Lysosomal Exocytosis and Plasma Membrane Resealing [PDF]

, 2019
Abstract Lysosomal exocytosis and resealing of damaged plasma membrane play critical roles in physiological and pathological processes, including, restoration of cellular homeostasis and tumor invasion. However, to-date, only a few regulatory molecules of these biological processes have been identified.
Nair, Sreeja V., Narendradev, Nikhil Dev, Nambiar, Rithwik P., Kumar, Rakesh, Srinivasula, Srinivasa M.   +4 more
openaire   +1 more source

Cell repair: Revisiting the patch hypothesis

Communicative & Integrative Biology, 2016
Plasma membrane damage elicits a complex and dynamic cellular response. A vital component of this response, membrane resealing, is thought to arise from fusion of intracellular membranous compartments to form a temporary, impermeant patch at the site of ...
Nicholas R. Davenport, William M. Bement
doaj   +1 more source

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation

Advanced Science, EarlyView.
Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Siddharth Mohanty, Mehmet Onur Aydogdu, Sijia Kang, Xinbo Li, Mohan Edirisinghe   +4 more
wiley   +1 more source