Results 41 to 50 of about 2,406 (159)
eLife, 2021 B-cell receptor (BCR)-mediated antigen internalization and presentation are essential for humoral memory immune responses. Antigen encountered by B-cells is often tightly associated with the surface of pathogens and/or antigen-presenting cells ...
Fernando Y Maeda +5 more
doaj +1 more source
Caveolae internalization repairs wounded cells and muscle fibers
eLife, 2013 Rapid repair of plasma membrane wounds is critical for cellular survival. Muscle fibers are particularly susceptible to injury, and defective sarcolemma resealing causes muscular dystrophy. Caveolae accumulate in dystrophic muscle fibers and caveolin and
Matthias Corrotte +10 more
doaj +1 more source
Dealing with damage: Plasma membrane repair mechanisms. [PDF]
, 2014 Eukaryotic cells have developed repair mechanisms, which allow them to reseal their membrane in order to prevent the efflux of cytoplasmic constituents and the uncontrolled influx of calcium. After injury, the Ca(2+)-concentration gradient fulfils a dual
Roman Schoenauer +9 more
core +1 more source
Journal of Cell Science, 2020 ABSTRACT Lysosomal exocytosis and resealing of damaged plasma membrane are essential for cellular homeostasis and tumor invasion. However, very little is known of the molecular machinery that regulates these physiological processes.
Sreeja V. Nair +4 more
openaire +2 more sources
Molecular Therapy: Nucleic Acids, 2018 Dysferlinopathy is a progressive myopathy caused by mutations in the dysferlin (DYSF) gene. Dysferlin protein plays a major role in plasma-membrane resealing.
Joshua J.A. Lee +4 more
doaj +1 more source
Into the breach: how cells cope with wounds [PDF]
Open Biology, 2018 Repair of wounds to individual cells is crucial for organisms to survive daily physiological or environmental stresses, as well as pathogen assaults, which disrupt the plasma membrane.
Mitsutoshi Nakamura +5 more
doaj +1 more source
The small chemical vacuolin-1 inhibits Ca2+-dependent lysosomal exocytosis but not cell resealing [PDF]
, 2004 Resealing after wounding, the process of repair following plasma membrane damage, requires exocytosis. Vacuolins are molecules that induce rapid formation of large, swollen structures derived from endosomes and lysosomes by homotypic fusion combined with
Tomas Kirchhausen +17 more
core +1 more source
Membrane resealing in cultured rat septal neurons after neurite transection: evidence for enhancement by Ca(2+)-triggered protease activity and cytoskeletal disassembly [PDF]
, 1991 Neurites of cultured septal neurons were transected with a laser under sterile conditions, and the subsequent membrane resealing was assayed using a dye exclusion method.
XY Xie, JN Barrett
core +1 more source
Naturally Occurring Shorter and Tumor-associated Mutant RNF167 Variants Facilitates Lysosomal Exocytosis and Plasma Membrane Resealing [PDF]
, 2019 Abstract Lysosomal exocytosis and resealing of damaged plasma membrane play critical roles in physiological and pathological processes, including, restoration of cellular homeostasis and tumor invasion. However, to-date, only a few regulatory molecules of these biological processes have been identified.
Nair, Sreeja V. +4 more
openaire +1 more source
Restructuring of the plasma membrane upon damage by LC3-associated macropinocytosis [PDF]
, 2021 The plasma membrane shapes and protects the eukaryotic cell from its surroundings and is crucial for cell life. Although initial repair mechanisms to reseal injured membranes are well established, less is known about how cells restructure damaged ...
Frankel, Lisa B. +7 more
core +1 more source