Results 51 to 60 of about 2,029,441 (265)

Pharmacokinetics of Tyrosol Metabolites in Rats

, 2016
Tyrosol is considered a potential antioxidant; however, little is known regarding the pharmacokinetics of its metabolites. To study the pharmacokinetics of tyrosol-derived metabolites after oral administration of a single dose of tyrosol, we attempted to
Jiyun Ahn, Chang Jung, Young Jin Jang, Chang Hwa Jung, Yang-Ji Kim, Min Jung Kim, Min Kim, Young Jang, Tae-Youl Ha, Sang Hee Lee, Sang Lee, Da-Hye Lee   +11 more
core   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes [PDF]

, 2015
This study was supported by funding from the UK Biotechnology and Biological Sciences Research Council Diet and Health Research Industry Club (BBSRC-DRINC) (BB/I006028/1) and by a studentship grant (BB/J500100/1).Scope: Flavonoids are generally studied ...
Kerr, J.S., Zhang, Q., O'Hagan, David, Kerr, Jason, Kay, C.D., Maria A. O'Connell, Sai Krishna Yalamanchili, Raheem, S., David O'Hagan, Colin D. Kay, O'Connell, M.A., O'Hagan, D., di Gesso, J.L., Kay, Colin, Jason S. Kerr, Saki Raheem, Zhang, Qingzhi, Krishna Yalamanchili, Sai, O’Hagan, D., Di Gesso, Jessica, O'Connell, Maria, Raheem, Saki, Yalamanchili, S.K., Jessica L. di Gesso, Qingzhi Zhang, O'Hagan, D.; id_orcid   +25 more
core   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Causal Relationships Between Immune Cell Traits, Plasma Metabolites, and Asthma: A Two‐Step, Two‐Sample Mendelian Randomization Study

The Clinical Respiratory Journal
Background Considerable evidence suggests a strong link between immune cell traits (ICTs) and asthma development via plasma metabolites (PMs), but the causality between ICTs and asthma is still unclear, mainly due to issues like selection bias.
Zhuozheng Hu, Peihao Xu, Jiajun Wu, Weijun Zhou, Yajie Zhou, Lei Xie, Wenxiong Zhang, Yong Cheng   +7 more
doaj   +1 more source

Causal association between plasma metabolites and diverse autoimmune diseases: a two-sample bidirectional mendelian randomization study

Frontiers in Immunology
BackgroundAutoimmune diseases (ADs) are a category of conditions characterized by misrecognition of autologous tissues and organs by the immune system, leading to severe impairment of patients’ health and quality of life.
Xiwen Yuan, Xiwen Yuan, Peiyan Yang, Peiyan Yang, Jiapeng Hu, Dixin Cai, Dixin Cai, Baoshan Hu, Baoshan Hu, Gang Rui, Gang Rui, Zhiming Lin, Zhiming Lin, Zhiming Lin   +13 more
doaj   +1 more source

plasma Metabolites

Plasma metabolites from RSV exacerbated asthmatic ...
Nicholas Lukacs (18414777)
core   +1 more source

Untargeted Plasma Lipidomics Reveal Perturbed Metabolites of Glycerophospholipids, and Sphingolipids in Moderate-to-Severe Acne

, 2023
Deng Zhang,1 Simin Yu,1 Xiaoliang Ou Yang,1 Xiuping Wang,1 Yunxia Zhu,1 Zhen Xiao,2 Yanping Tan,3 Liang Wu,1 Chunming Li1 1Department of Dermatology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China ...
Zhang D, Wu L, Li C, Yu S, Zhu Y, Xiao Z, Tan Y, Ou Yang X, Wang X   +8 more
core  

Identification of non‐reported bupropion metabolites in human plasma [PDF]

, 2016
Bupropion and its three active metabolites exhibit clinical efficacy in the treatment of major depression, seasonal depression and smoking cessation. The pharmacokinetics of bupropion in humans is highly variable.
Jim Windak, Ellingrod, Vicki L., McInnis, Melvin, Luo, Ruijuan, Harrington, Gloria, Windak, Jim, Andrew Babiskin, Zhang, Xinyuan, Marisa Kelly, Gloria Harrington, Babiskin, Andrew, Duxin Sun, Connarn, Jamie N., Sun, Duxin, Kelly, Marisa, Ruijuan Luo, Jamie N. Connarn, Xinyuan Zhang, Vicki L. Ellingrod, Melvin McInnis, Masoud Kamali, Kamali, Masoud   +21 more
core   +1 more source