Results 31 to 40 of about 2,029,441 (265)

Dissecting the causal relationship between insomnia, plasma metabolites, and anxiety: A mediated mendelian randomization study

Journal of Affective Disorders Reports
Objective: This study employed a two-sample Mendelian randomization (MR) approach to investigate the causal relationships among insomnia, plasma metabolites, and anxiety disorders.
Qi Fan, Jiaxin Li, Yushi Tian, Qingyuan Meng, Mingyue Lan, Xiaoyang Hu   +5 more
doaj   +1 more source

Plasma levels of hormones and metabolites.

, 2018
Plasma levels of hormones and metabolites.
Jens Otto Lunde Jørgensen (597493), Rikke Viggers (5720702), Ann Mosegaard Bak (5720699), Niels Jessen (204038), Mikkel Holm Vendelbo (597489), Bo Martin Bibby (346318), Jørgen Rungby (365710), Britt Christensen (331601), Niels Møller (105863)   +8 more
core   +1 more source

Exploring causal associations between plasma metabolites and attention-deficit/hyperactivity disorder

BMC Psychiatry
Background Observational studies reported altered levels of plasma metabolites in attention-deficit/hyperactivity disorder (ADHD). We aim to explore the causal link between plasma metabolites and ADHD.
Shangyun Shi, Ancha Baranova, Hongbao Cao, Fuquan Zhang   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Causal effects of plasma metabolites on chronic kidney diseases and renal function: a bidirectional Mendelian randomization study

Frontiers in Endocrinology
BackgroundDespite the potential demonstrated by targeted plasma metabolite modulators in halting the progression of chronic kidney disease (CKD), a lingering uncertainty persists concerning the causal relationship between distinct plasma metabolites and ...
Xiaodong Zhao, Jialin Gao, Kai Kou, Xi Wang, Xin Gao, Yishu Wang, Honglan Zhou, Faping Li   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Causal relationships between glycemic traits and adverse pregnancy outcomes and the mediating role of plasma metabolites: a Mendelian randomization study [PDF]

Yixue xinzhi zazhi
Objective To investigate the causal association among glycemic traits, plasma metabolites, and adverse pregnancy outcomes (APOs), as well as potential mediating mechanisms, using Mendelian randomization (MR).Methods Based on summary data from genome-wide
ZHOU Yuejing, XU Dan, ZHONG Caiyun
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Plasma and Urine Metabolites Associated With Nondiabetic Chronic Kidney Disease: The HELIUS Study

Kidney Medicine
Rationale & Objective: We aimed to find predictive plasma and urine metabolites for nondiabetic chronic kidney disease (CKD), and to validate these biomarkers in a diabetic kidney disease (DKD) population, using data of the population-based ...
Charlotte M. Mosterd, Barbara J.H. Verhaar, Bert-Jan H. van den Born, Max Nieuwdorp, Daniel H. van Raalte   +4 more
doaj   +1 more source

Acknowledgment to Reviewers of Metabolites in 2020

, 2021
Peer review is the driving force of journal development, and reviewers are gatekeepers who ensure that Metabolites maintains its standards for the high quality of its published papers [...
Metabolites Editorial Office Metabolites Editorial Office, Metabolites Editorial Office, null null   +2 more
core   +1 more source