Results 21 to 30 of about 58,767 (165)
The uPA System Differentially Alters Fibroblast Fate and Profibrotic Ability in Skin Fibrosis
Frontiers in Immunology, 2022 Skin fibrosis is a common pathological feature of various diseases, and few treatment strategies are available because of the molecular pathogenesis is poorly understood.
Ming-Li Zou +15 more
doaj +1 more source
Corrigendum: Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 complex as a serum biomarker for COVID-19 [PDF]
Frontiers in ImmunologyTetiana Yatsenko +12 more
doaj +2 more sources
Platelets retain high levels of active plasminogen activator inhibitor 1. [PDF]
PLoS ONE, 2011 The vascular fibrinolytic system is crucial for spontaneous lysis of blood clots. Plasminogen activator inhibitor 1 (PAI-1), the principal inhibitor of the key fibrinolytic enzyme tissue-type plasminogen activator (tPA), is present in platelets at high ...
Helén Brogren +4 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2021 Plasminogen activator inhibitor 1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily. PAI-1 is the principal inhibitor of the plasminogen activators, tissue plasminogen activator (tPA), and urokinase-type plasminogen activator (uPA)
Gael B. Morrow +3 more
doaj +1 more source
Scientific Reports, 2017 Plasminogen activator inhibitor-1 (PAI-1) is known to protect mice against cardiac fibrosis. It has been speculated that PAI-1 may regulate cardiac fibrosis by inactivating urokinase-type plasminogen activator (uPA) and ultimately plasmin (Pm) generation.
Kamlesh K. Gupta +4 more
doaj +1 more source
Scientific Reports, 2022 Older adult surgical patients are susceptible to developing delirium. Early intervention can be initiated if a potential biomarker associated with delirium can be identified during the acute phase of surgery. Therefore, we investigated the changes in the
Kazuhito Mietani +8 more
doaj +1 more source
Association of Celiac Disease and Plasminogen Activator Inhibitor-1 Polymorphism
Genel Tıp Dergisi, 2022 Objective: Celiac disease (CD) is an autoimmune disease. Although susceptibility to thrombosis in celiac patients has been reported in case studies, the cause is not yet known. PAI-1 inhibits fibrinolysis.
Nur Ramoğlu +3 more
doaj +1 more source
Components of the plasminogen activation system promote engraftment of porous polyethylene biomaterial via common and distinct effects. [PDF]
PLoS ONE, 2015 Rapid fibrovascularization is a prerequisite for successful biomaterial engraftment. In addition to their well-known roles in fibrinolysis, urokinase-type plasminogen activator (uPA) and tissue plasminogen activator (tPA) or their inhibitor plasminogen ...
Christoph A Reichel +8 more
doaj +1 more source
Oman Medical Journal, 2013 Objectives: This study was aimed to determine plasma levels of total (TFPI-T) and free (TFPI-F) tissue factor pathway inhibitor, plasminogen activator inhibitor-1 (PAI-1), and tissue plasminogen activator (t-PA) in a cohort of Saudi patients with chronic
Syed Shahid Habib
doaj +1 more source
SOME FIBRINOLYTIC PARAMETERS IN CORONARY ARTERY DISEASE PATIENTS: FOCUS ON UNSTABLE ANGINA SUBGROUPS
Східноукраїнський медичний журнал, 2021 Background and aim. Unstable angina is classified into new-onset, progressive, and angina at rest. Though hemostasis plays a crucial role in the pathogenesis of coronary artery disease, including unstable angina, limited data exist regarding ...
Y. V. Tyravska +4 more
doaj +1 more source