Results 41 to 50 of about 58,767 (165)
Clinical significance of measuring plasminogen activator inhibitor-1 in sepsis
Journal of Intensive Care, 2017 Background Disseminated thrombotic process in the microcirculation is considered to be an important cause of multiple organ dysfunction in sepsis.
Toshiaki Iba, Jecko Thachil
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Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer
Cell Reports, 2018 Summary: Plasminogen activator inhibitor-1 (PAI-1) has a pro-tumorigenic function via its pro-angiogenic and anti-apoptotic activities. Here, we demonstrate that PAI-1 promotes the recruitment and M2 polarization of monocytes/macrophages through ...
Marta Helena Kubala +6 more
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Biochemical properties of plasminogen activator inhibitor-1
Frontiers in Bioscience, 2009 PAI-1 is a Mr ~50,000 glycoprotein, which is the primary physiological inhibitor of the two plasminogen activators uPA and tPA. PAI-1 belongs to the serpin protein family. Studies of PAI-1 have contributed significantly to the elucidation of the protease inhibitory mechanism of serpins, which is based on a metastable native state becoming stabilised by
Dupont, Daniel Miotto +6 more
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Host cell and viral protease targets of human SERPINs identified by in silico docking
The EMBO JournalSerine protease inhibitors (SERPINs) are involved in various physiological processes and diseases, such as inflammation, cancer metastasis, and neurodegeneration.
Joaquin Rodriguez Galvan +9 more
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Plasminogen activator inhibitor-1 in cancer research
Biomedicine & Pharmacotherapy, 2018 [Despite as a major inhibitor of urokinase (uPA), paradoxically,] Plasminogen activator inhibitor-1 (PAI-1) has been validated to be highly expressed in various types of tumor biopsy tissues or plasma compared with controls based on huge clinical data bases analysis, more importantly, PAI-1 alone or in conjunction with uPA have been identified as ...
Sijing, Li +5 more
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Diabetes, Metabolic Syndrome and Obesity, 2013 Olga Gruzdeva, Evgenya Uchasova, Yulia Dyleva, Ekaterina Belik, Ekaterina Shurygina, Olga Barbarash Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian ...
Gruzdeva O +5 more
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Pleiotropic functions of plasminogen activator inhibitor-1 [PDF]
Journal of Thrombosis and Haemostasis, 2005 Plasminogen activator inhibitor-1 (PAI-1), a 45-kDa serine proteinase inhibitor with reactive site peptide bond Arg345-Met346, is the main physiological plasminogen activator inhibitor. It occurs in human plasma at an antigen concentration of about 20 ng mL(-1).
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Plasminogen Activator Inhibitor-1
JACC: Basic to Translational Science, 2022 Dimitri Arangalage +2 more
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Association between Plasma Levels of Plasminogen Activator Inhibitor-1 and Colorectal Neoplasms
Gut and Liver, 2013 Background/AimsPlasminogen activator inhibitor-1 (PAI-1) is important for tumor growth, Invasion, and metastasis. In this study, we investigated the relationship between plasma levels of PAI-1 and colorectal adenomas.Methods : We reviewed the medical ...
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Cancer Biology & Medicine, 2009 OBJECTIVE To investigate the expression of urokinase-type plasminogen (uPA), its inhibitor-1 (PAI-1) mRNA and its protein in human gastric cancer and to fi nd out the relationship among the tumor differentiation, angiogenesis, and other clinical ...
Jifeng WU, Xia SHENG, Rong QIN, Hong ZHANG
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