Premature delivery impacts the concentration of plasminogen activators and a plasminogen activator inhibitor and the plasmin activity in human milk [PDF]
Frontiers in Pediatrics, 2022 Background and aimsPlasmin in human milk partially hydrolyzes milk proteins within the mammary gland and may enhance the hydrolysis of milk proteins within the infant’s stomach. This study examined the effects of extremely preterm (EP)-, very preterm (VP)
Veronique Demers-Mathieu +2 more
doaj +2 more sources
Targeted Delivery of Plasminogen Activators for Thrombolytic Therapy: An Integrative Evaluation [PDF]
Molecules, 2019 In thrombolytic therapy, plasminogen activators (PAs) are still the only group of drug approved to induce thrombolysis, and therefore, critical for treatment of arterial thromboembolism, such as stroke, in the acute phase.
Yunn-Hwa Ma +4 more
doaj +2 more sources
Structural basis of specific inhibition of tissue-type plasminogen activator by plasminogen activators inhibitor-1 [PDF]
Data in Brief, 2016 Thrombosis is a leading cause of death worldwide [1]. Recombinant tissue-type plasminogen activator (tPA) is the FDA-approved thrombolytic drug for ischemic strokes, myocardial infarction and pulmonary embolism.
Lihu Gong +6 more
doaj +2 more sources
Support vector machine (SVM) based multiclass prediction with basic statistical analysis of plasminogen activators. [PDF]
BMC Res Notes, 2014 Plasminogen (Pg), the precursor of the proteolytic and fibrinolytic enzyme of blood, is converted to the active enzyme plasmin (Pm) by different plasminogen activators (tissue plasminogen activators and urokinase), including the bacterial activators ...
Muthukrishnan S, Puri M, Lefevre C.
europepmc +3 more sources
A Contemporary Review of Plasminogen Activator Inhibitor Type 1: Structure, Function, Genetic Architecture, and Intracellular/Extracellular Roles [PDF]
TH OpenPlasminogen activator inhibitor type 1 (PAI-1) is the key regulator of the fibrinolytic system, thereby acting as a potent mediator in thrombosis. Plasminogen activators such as PAI-1 mediate the conversion of the inactive zymogen plasminogen to plasmin,
Jacob Wortley +4 more
doaj +2 more sources
Differences and Compatibility between Human and Porcine Fibrinolytic Components toward Plasmin Generation and Fibrin Degradation [PDF]
TH OpenPaul Y. Kim +3 more
doaj +2 more sources
Plasmin plays an essential role in amplification of psoriasiform skin inflammation in mice. [PDF]
PLoS ONE, 2011 BACKGROUND:Although increased levels of plasminogen activators have been found in psoriatic lesions, the role of plasmin converted from plasminogen by plasminogen activators in pathogenesis of psoriasis has not been investigated.
Qun Li +8 more
doaj +1 more source
Plasminogen activator inhibitors [PDF]
Blood, 1987 Chemicals/CAS: fibrin, 9001-31-4; plasminogen activator inhibitor, 105844-41-5; plasminogen activator, 9039-53-6; Carrier Proteins; Glycoproteins; Plasminogen Activators, EC 3.4.21.-; Plasminogen Inactivators; Protease Inhibitors; protease ...
Sprengers, E.D., Kluft, C.
openaire +4 more sources
Fibrinolysis regulation by platelets retaining plasminogen and tissue-type plasminogen activator on their surface [PDF]
The Ukrainian Biochemical Journal, 2019 Platelets play a key role in hemostasis as cofactors of thrombin generation, fibrin polymerization centers, and initiators of clot retraction, while their ability to modulate clot dissolution remains less understood.
T. Grinenko +4 more
doaj +1 more source
A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection. [PDF]
PLoS Pathogens, 2013 Recruitment of the serine protease plasmin is central to the pathogenesis of many bacterial species, including Group A streptococcus (GAS), a leading cause of morbidity and mortality globally.
Martina L Sanderson-Smith +9 more
doaj +1 more source