Results 101 to 110 of about 3,326,153 (390)

Sites of synthesis of urokinase and tissue-type plasminogen activators in the murine kidney.

Journal of Clinical Investigation, 1991
Kidneys have long been recognized as a major source of plasminogen activators (PAs). However, neither the sites of synthesis of the enzymes nor their role in renal function have been elucidated.
André-Pascal Sappino, J. Huarte, Jean-Dominique Vassalli, Dominique Belin   +3 more
semanticscholar   +1 more source

PCSK‐9 Inhibitors Can Significantly Improve the Coronary Slow Flow Caused by Elevated Lipoprotein (a) in ST‐Elevation Myocardial Infarction Patients With Chronic Kidney Disease

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Coronary slow flow and no reflow significantly predict poor prognosis in acute myocardial infarction (AMI) patients, especially those with chronic kidney disease (CKD). Early identification of factors contributing to these conditions can mitigate ischemic events and improve outcomes.
Hao Xu, Ziqing Wang, Dan Chen, Haojie Zhang, Junhua Ge, Jian Li   +5 more
wiley   +1 more source

Contribution of macrophages to plasmin activity in ewe bulk milk

Italian Journal of Animal Science, 2010
A total of 225 bulk sheep milk samples were collected throughout lactation to assess the contribution of macrophages to the regulation of the plasmin/plasminogen system. Samples were analyzed for composition, milk renneting parameters, and for activities
M. Albenzio, A. Sevi, A. Marzano, R. Marino, L. Schena, M. Caroprese   +5 more
doaj   +1 more source

Urokinase- and tissue-type plasminogen activators in keratinocytes during wound reepithelialization in vivo.

Journal of Investigative Dermatology, 1988
Urokinase- and tissue-type plasminogen activators (u-PA and t-PA) were identified immunohistochemically during reepithelialization of mouse and human skin wounds, by means of polyclonal and monoclonal antibodies.
J. Grøndahl-Hansen, J. Grøndahl-Hansen, L. Lund, L. Lund, E. Ralfkiær, E. Ralfkiær, V. Ottevanger, V. Ottevanger, K. Danø, K. Danø   +9 more
semanticscholar   +1 more source

Characterizing plasmin-induced lag phase and application of PDMS microfluidics to detection of fibrinolytic activity [PDF]

, 2018
Physical trauma is responsible for over six million deaths annually, and of these roughly 40 percent result from acute traumatic coagulopathy (ATC) occurring in the first few hours of incidence. Patients who have developed ATC have significantly improved
Ghani, Naveed
core  

Design of Potent Mannose‐6‐Phosphate Derivatives as Ligands for CI‐M6P/IGF2R Using Fluorescence Polarization Assay

Chemistry – A European Journal, EarlyView.
We designed and synthesized novel mannose‐6‐phosphate (M6P) derivatives to enhance their binding affinity for the CI‐M6P/IGF2 receptor, which plays a key role in lysosomal targeting. Using a fluorescence polarization assay, we evaluated di‐, tri‐, and penta‐M6P peptides and modified M6P analogs.
Lucie Mrázková, Klaudia Hladoníková, Barbora Toncarová, Michal Fischer, Jakub Zýka, Jaroslav Kozák, Michal Kráľ, Milan Kožíšek, Jiří Jiráček, Jakub Kaminský, Kamil Parkan, Lenka Žáková   +11 more
wiley   +1 more source

Determination of plasminogen/plasmin system components and indicators of lipoproteins oxidative modification under arterial hypertension

The Ukrainian Biochemical Journal, 2018
The present study was investigated of levels of oxidative modification of lipoproteins and content of plasminogen/plasmin system components – tissue-type plasminogen activator (t-PA) and plasminogen activators inhibitor-1 (PAI-I), in patients with stage ...
O. I. Yusova, O. V. Savchuk, T. V. Grinenko, O. B. Kuchmenko, L. S. Mhitaryan, O. H. Kupchins’ka, I. N. Yevstratova, O. O. Matova, N. M. Vasilinchuk, T. F. Drobot’ko   +9 more
doaj   +1 more source

MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients. [PDF]

, 2012
BackgroundUpregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients.MethodsWe assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in ...
Hardwick, JCH, Hawinkels, LJAC, Hommes, DW, Kubben, FJGM, Langers, AMJ, Sier, CFM, van der Reijden, JJ, van Duijn, W, Verspaget, HW   +8 more
core   +1 more source

Deferasirox Derivatives as Inhibitors of Kallikrein‐Related Peptidases Associated to Neurodegenerative Diseases

ChemMedChem, EarlyView.
Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali, Elodie David, Nancy Chaaya, Morane Lucas, Sabrina Aït Amiri, Valérie Lefort, Anthony Nina‐Diogo, Michèle Salmain, Isabelle Petropoulos, Vincent Corcé, Chahrazade El Amri, Candice Botuha   +11 more
wiley   +1 more source

Angiostatin generating capacity and anti-tumour effects of D-penicillamine and plasminogen activators

BMC Cancer, 2006
Background Upregulation of endogenous angiostatin levels may constitute a novel anti-angiogenic, and therefore anti-tumor therapy. In vitro, angiostatin generation is a two-step process, starting with the conversion of plasminogen to plasmin by ...
Maass Cathy N, Lamers-Elemans Iris L, Ruers Theo JM, de Groot-Besseling Renate RJ, de Waal Robert MW, Westphal Johan R   +5 more
doaj   +1 more source