Activation of Plasminogen by Staphylokinase [PDF]
Nature, 1960 SOME animal plasminogens, which are unaffected by streptokinase alone, are activated by streptokinase and human globulin. Mullertz1 has postulated the existence of a proactivator in human serum. Staphylokinase, without human globulin, activates a wider range of animal plasminogens2 and may, therefore, not require proactivator.
Flora M. Davidson
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Plasminogen Activators in Neurovascular and Neurodegenerative Disorders. [PDF]
Int J Mol Sci, 2021 The neurovascular unit (NVU) is a dynamic structure assembled by endothelial cells surrounded by a basement membrane, pericytes, astrocytes, microglia and neurons.
Yepes M, Woo Y, Martin-Jimenez C.
europepmc +2 more sources
Premature delivery impacts the concentration of plasminogen activators and a plasminogen activator inhibitor and the plasmin activity in human milk. [PDF]
Front Pediatr, 2022 Background and aimsPlasmin in human milk partially hydrolyzes milk proteins within the mammary gland and may enhance the hydrolysis of milk proteins within the infant’s stomach. This study examined the effects of extremely preterm (EP)-, very preterm (VP)
Demers-Mathieu V +2 more
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Targeted Delivery of Plasminogen Activators for Thrombolytic Therapy: An Integrative Evaluation. [PDF]
Molecules, 2019 In thrombolytic therapy, plasminogen activators (PAs) are still the only group of drug approved to induce thrombolysis, and therefore, critical for treatment of arterial thromboembolism, such as stroke, in the acute phase.
Ma YH, Liu CH, Liang Y, Chen JP, Wu T.
europepmc +2 more sources
Bioprinted Micro-Clots for Kinetic Analysis of Endothelial Cell-Mediated Fibrinolysis. [PDF]
Adv Healthc MaterThis paper describes the development of a microscale model that quantifies the breakdown of fibrin by endothelial cells. The small size scale of this engineered system enables fibrin breakdown to be observed without the addition of external activators. This system could help in identifying compounds which both promote and hinder thrombosis.
Chang JJ +5 more
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Structural basis of specific inhibition of tissue-type plasminogen activator by plasminogen activators inhibitor-1. [PDF]
Data Brief, 2016 Thrombosis is a leading cause of death worldwide [1]. Recombinant tissue-type plasminogen activator (tPA) is the FDA-approved thrombolytic drug for ischemic strokes, myocardial infarction and pulmonary embolism.
Gong L +6 more
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Blood, 2015 Persistent intracerebral hemorrhage (ICH) is a major cause of death and disability after traumatic brain injury (TBI) for which no medical treatment is available.
Hijazi N +9 more
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International Journal of Molecular Sciences, 2021 Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of plasminogen activators (PAs) and is therefore an important inhibitor of the plasminogen/plasmin system.
M. Sillen, P. Declerck
semanticscholar +1 more source
Fibrinolysis regulation by platelets retaining plasminogen and tissue-type plasminogen activator on their surface [PDF]
The Ukrainian Biochemical Journal, 2019 Platelets play a key role in hemostasis as cofactors of thrombin generation, fibrin polymerization centers, and initiators of clot retraction, while their ability to modulate clot dissolution remains less understood.
T. Grinenko +4 more
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The Plasminogen–Activator Plasmin System in Physiological and Pathophysiological Angiogenesis
International Journal of Molecular Sciences, 2021 Angiogenesis is a process associated with the migration and proliferation of endothelial cells (EC) to form new blood vessels. It is involved in various physiological and pathophysiological conditions and is controlled by a wide range of proangiogenic ...
A. Ismail, B. Shaker, K. Bajou
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