Results 11 to 20 of about 13,392 (262)
Proteolytic enzyme and adiponectin receptors as potential targets for COVID-19 therapy
Кардиоваскулярная терапия и профилактика, 2021 The coronavirus disease 2019 (COVID-19) pandemic requires not only the creation of vaccines to prevent the spread of the disease, but also the development of novel drugs aimed at reducing viral load, suppressing an excessive immune response and ...
K. A. Rubina +5 more
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Annals of Cardiac Anaesthesia, 2020 Prosthetic valve thrombosis (PVT) is a rare but life-threatening complication. It has an incidence of 6.1% in developing countries and 0.3%–1.3% in developed countries.
Hasan Haghaninejad +2 more
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Location, location, location: Fibrin, cells, and fibrinolytic factors in thrombi
Frontiers in Cardiovascular Medicine, 2023 Thrombi are heterogenous in nature with composition and structure being dictated by the site of formation, initiating stimuli, shear stress, and cellular influences. Arterial thrombi are historically associated with high platelet content and more tightly
Anuj Narwal +2 more
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Fibrinolysis and bleeding of unknown cause
Research and Practice in Thrombosis and Haemostasis, 2021 Patients with bleeding of unknown cause (BUC) present with a variety of mild to moderate bleeding symptoms, but no hemostatic abnormalities can be found. Hyperfibrinolysis is rarely evaluated as the underlying cause for bleeding in clinical practice, and
Dino Mehic +3 more
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Journal of Baghdad College of Dentistry, 2022 Background: Monocyte chemotactic protein-1 (MCP-1) is a chemokine expressed by inflammatory and endothelial cells. It has a crucial role in initiating, regulating, and mobilizing monocytes to active sites of periodontal inflammation.
Safa A Hamad , Maha S Mahmood
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The X-ray Crystal Structure of Full-Length Human Plasminogen
Cell Reports, 2012 Plasminogen is the proenzyme precursor of the primary fibrinolytic protease plasmin. Circulating plasminogen, which comprises a Pan-apple (PAp) domain, five kringle domains (KR1-5), and a serine protease (SP) domain, adopts a closed, activation-resistant
Ruby H.P. Law +13 more
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Phosphorylation of human plasminogen activators and plasminogen [PDF]
FEBS Letters, 1995 Plasminogen (PG), urokinase‐type plasminogen activator (u‐PA) and tissue‐type PA (t‐PA) are the main molecules involved in fibrinolysis and in many other physiological and pathological processes. In the present study we report that human t‐PA, purified from human melanoma cells, and PG, purified from human plasma, both contain P‐Tyr residues, as ...
BARLATI, Sergio +4 more
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Plasminogen activators and plasminogen activator inhibitors in endometriosis
Frontiers in Bioscience, 2005 Endometriosis is one of the most frequent benign gynecological diseases that affect women. Little is known about the pathogenesis and etiology of endometriosis, despite the numerous studies performed in this field. Although endometriosis is a benign disease, the endometrial tissue, after attachment to the peritoneum, has the ability to grow and invade ...
Gilabert-Estelles, J +6 more
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Plasminogen activators in acute management of thrombosis
Российский кардиологический журнал, 2013 The paper focuses on the problem of intravascular thrombosis and the methods of its treatment. The data on haemostasis pathophysiology, which underlie the occurrence of acute ischemic events in humans, are presented, together with the data on the action ...
E. O. Taratukhin
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Scientific Reports, 2021 Plasmin is the key enzyme in fibrinolysis. Upon interaction with plasminogen activators, the zymogen plasminogen is converted to active plasmin. Some studies indicate plasminogen activation is regulated by cation-independent mannose 6-phosphate receptor (
James J. Miller +6 more
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