Results 21 to 30 of about 3,326,153 (390)

A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection. [PDF]

PLoS Pathogens, 2013
Recruitment of the serine protease plasmin is central to the pathogenesis of many bacterial species, including Group A streptococcus (GAS), a leading cause of morbidity and mortality globally.
Martina L Sanderson-Smith, Yueling Zhang, Diane Ly, Deborah Donahue, Andrew Hollands, Victor Nizet, Marie Ranson, Victoria A Ploplis, Mark J Walker, Francis J Castellino   +9 more
doaj   +1 more source

Contribution of plasminogen activation towards the pathogenic potential of oral streptococci. [PDF]

PLoS ONE, 2010
Oral streptococci are a heterogeneous group of human commensals, with a potential to cause serious infections. Activation of plasminogen has been shown to increase the virulence of typical human pathogenic streptococci such as S. pneumoniae.
Andreas Itzek, Christine M Gillen, Marcus Fulde, Claudia Friedrichs, Arne C Rodloff, Gursharan S Chhatwal, Daniel Patric Nitsche-Schmitz   +6 more
doaj   +1 more source

Proteolytic enzyme and adiponectin receptors as potential targets for COVID-19 therapy

Кардиоваскулярная терапия и профилактика, 2021
The coronavirus disease 2019 (COVID-19) pandemic requires not only the creation of vaccines to prevent the spread of the disease, but also the development of novel drugs aimed at reducing viral load, suppressing an excessive immune response and ...
K. A. Rubina, N. R. Sabitova, A. Yu. Efimenko, N. I. Kalinina, J. A. Akopyan, E. V. Semina   +5 more
doaj   +1 more source

Repeat reteplase therapy in a patient with recurrent prosthetic tricuspid valve thrombosis after trido multiple valve replacement

Annals of Cardiac Anaesthesia, 2020
Prosthetic valve thrombosis (PVT) is a rare but life-threatening complication. It has an incidence of 6.1% in developing countries and 0.3%–1.3% in developed countries.
Hasan Haghaninejad, Somaye Fallahzade, Mohammadreza Pagardkar   +2 more
doaj   +1 more source

Location, location, location: Fibrin, cells, and fibrinolytic factors in thrombi

Frontiers in Cardiovascular Medicine, 2023
Thrombi are heterogenous in nature with composition and structure being dictated by the site of formation, initiating stimuli, shear stress, and cellular influences. Arterial thrombi are historically associated with high platelet content and more tightly
Anuj Narwal, Claire S. Whyte, Nicola J. Mutch   +2 more
doaj   +1 more source

Fibrinolysis and bleeding of unknown cause

Research and Practice in Thrombosis and Haemostasis, 2021
Patients with bleeding of unknown cause (BUC) present with a variety of mild to moderate bleeding symptoms, but no hemostatic abnormalities can be found. Hyperfibrinolysis is rarely evaluated as the underlying cause for bleeding in clinical practice, and
Dino Mehic, Ingrid Pabinger, Cihan Ay, Johanna Gebhart   +3 more
doaj   +1 more source

Assessment of serum levels of monocyte chemoattractant protein 1 (MCP 1) in patients with periodontitis and atherosclerotic cardiovascular disease

Journal of Baghdad College of Dentistry, 2022
Background: Monocyte chemotactic protein-1 (MCP-1) is a chemokine expressed by inflammatory and endothelial cells. It has a crucial role in initiating, regulating, and mobilizing monocytes to active sites of periodontal inflammation.
Safa A Hamad , Maha S Mahmood
doaj   +1 more source

The X-ray Crystal Structure of Full-Length Human Plasminogen

Cell Reports, 2012
Plasminogen is the proenzyme precursor of the primary fibrinolytic protease plasmin. Circulating plasminogen, which comprises a Pan-apple (PAp) domain, five kringle domains (KR1-5), and a serine protease (SP) domain, adopts a closed, activation-resistant
Ruby H.P. Law, Tom Caradoc-Davies, Nathan Cowieson, Anita J. Horvath, Adam J. Quek, Joanna Amarante Encarnacao, David Steer, Angus Cowan, Qingwei Zhang, Bernadine G.C. Lu, Robert N. Pike, A. Ian Smith, Paul B. Coughlin, James C. Whisstock   +13 more
doaj   +1 more source

Streptolysin O accelerates the conversion of plasminogen to plasmin. [PDF]

Nat Commun
Group A Streptococcus (GAS) is a human-specific bacterial pathogen that can exploit the plasminogen-plasmin fibrinolysis system to dismantle blood clots and facilitate its spread and survival within the human host.
Tang D, Khakzad H, Hjortswang E, Malmström L, Ekström S, Happonen L, Malmström J.   +6 more
europepmc   +2 more sources

Different N-Glycosylation Sites Reduce the Activity of Recombinant DSPAα2

Current Issues in Molecular Biology, 2022
Bat plasminogen activators α2 (DSPAα2) has extremely high medicinal value as a powerful natural thrombolytic protein. However, wild-type DSPAα2 has two N-glycosylation sites (N185 and N398) and its non-human classes of high-mannose-type N-glycans may ...
Huakang Peng, Mengqi Wang, Nan Wang, Caifeng Yang, Wenfang Guo, Gangqiang Li, Sumei Huang, Di Wei, Dehu Liu   +8 more
doaj   +1 more source