Results 61 to 70 of about 54,262 (254)

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes [PDF]

, 2010
Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-ß signalling pathway components such as Smad2, Smad3 and Smad7. Our studies in
Andrew D. Rowan, Bain, Cao, Chen, Chen, Cho, Clayton, David A. Young, de Ruijter, Denker, Dennler, Derynck, Dylan R. Edwards, Fecteau, Gary J. Litherland, Ghosh, Glenisson, Glozak, Gottlicher, Gregoretti, Gurvich, Hazzalin, Horowitz, Ian M. Clark, Khan, Kobayashi, Kouzarides, Kuang, Kwak, Le Pabic, Le Pabic, Lee, Leon Pybus, Li, Lien, Litherland, Mahlknecht, Matt J. Barter, Michaelis, Rombouts, Shi, Tim E. Cawston, Togi, Tu, Vannini, Verdin, Wang, Whitmarsh, Wrana, Xu, Yamaguchi, Yoshikawa, Young, Yu, Zhang   +54 more
core   +1 more source

Streptolysin O accelerates the conversion of plasminogen to plasmin

Nature Communications
Group A Streptococcus (GAS) is a human-specific bacterial pathogen that can exploit the plasminogen-plasmin fibrinolysis system to dismantle blood clots and facilitate its spread and survival within the human host.
Di Tang, Hamed Khakzad, Elisabeth Hjortswang, Lars Malmström, Simon Ekström, Lotta Happonen, Johan Malmström   +6 more
doaj   +1 more source

Roles and regulation of membrane-associated serine proteases [PDF]

, 2007
Pericellular proteolytic activity affects many aspects of cellular behaviour, via mechanisms involving processing of the extracellular matrix, growth factors and receptors.
Bass, Rosemary, Ellis, V, Gray, Kelly, Owen, K, Qiu, Deyi   +4 more
core   +1 more source

Targeted Thrombolysis with Magnetic Nanotherapeutics: A Translational Assessment

Pharmaceutics
Plasminogen activators, such as recombinant tissue-type plasminogen activators (rtPAs), while effective in treating thromboembolic diseases, often induce hemorrhagic complications due to non-specific enzyme activities in the systemic circulation.
Ming-Lu Lin, Siao-Yun Wu, Jyh-Ping Chen, Yi-Ching Lu, Shih-Ming Jung, Shiaw-Pyng Wey, Tony Wu, Yunn-Hwa Ma   +7 more
doaj   +1 more source

Plasminogen activation in the musculoskeletal acute phase response: Injury, repair, and disease

Research and Practice in Thrombosis and Haemostasis, 2020
The musculoskeletal system is critical for movement and the protection of organs. In addition to abrupt injuries, daily physical demands inflict minor injuries, necessitating a coordinated process of repair referred to as the acute‐phase response (APR ...
Breanne H.Y. Gibson, Matthew T. Duvernay, Stephanie N. Moore‐Lotridge, Matthew J. Flick, Jonathan G. Schoenecker   +4 more
doaj   +1 more source

Clinical significance of measuring plasminogen activator inhibitor-1 in sepsis

Journal of Intensive Care, 2017
Background Disseminated thrombotic process in the microcirculation is considered to be an important cause of multiple organ dysfunction in sepsis.
Toshiaki Iba, Jecko Thachil
doaj   +1 more source

Interference with the Host Haemostatic System by Schistosomes [PDF]

, 2013
Schistosomes, parasitic flatworms that cause the tropical disease schistosomiasis, are still a threat. They are responsible for 200 million infections worldwide and an estimated 280,000 deaths annually in sub-Saharan Africa alone.
Genderen, P.J.J. (Perry) van, Groot, P.G. (Philip) de, Hellemond, J.J. (Jaap) van, Mebius, M.M. (Mirjam), Tielens, A.G.M. (Lodewijk), Urbanus, R.T. (Rolf)   +5 more
core   +2 more sources

Relationship Between Language Preference and Intravenous Thrombolysis Among Acute Ischemic Stroke Patients

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Background Approximately 20% of the US population primarily speaks a language other than English at home. Yet the effect of language preference on treatment of acute ischemic stroke (AIS) patients remains unknown.
Betty Luan Erfe, Khawja Ahmeruddin Siddiqui, Lee H. Schwamm, Nicte I. Mejia   +3 more
doaj   +1 more source

Measuring the metastatic potential of cancer cells [PDF]

, 1993
Cancer cells must secrete proteolytic enzymes to invade adjacent tissues and migrate to a new metastatic site. Urokinase (uPA) is a key enzyme related to metastasis in cancers of the lung, colon, gastric, uterine, breast, brain, and malignant melanoma. A
Atassi, M. Z., Gratzner, Howard, Morrison, Dennis R.   +2 more
core   +1 more source

Clotting activation and impairment of fibrinolysis in malignancy [PDF]

, 1989
Different coagulation and fibrinolysis parameters were investigated in 149 patients with metastatic and non-metastatic tumours and results were compared with those obtained in a healthy population.
Cuesta, B. (Braulia), Fernandez, F.J. (Francisco J.), Hernández, M. (M.), Paloma, M.J. (María José), Paramo, J.A. (José Antonio), Rifon, J. (Jose), Rocha, E. (Eduardo)   +6 more
core   +1 more source