Acceleration of the thrombin inactivation of single chain urokinase-type plasminogen activator (pro-urokinase) by thrombomodulin. [PDF]
Journal of Clinical Investigation, 1991 The in vitro effects of thrombomodulin on the inactivation of single chain urokinase-type plasminogen activator (scu-PA) by thrombin were investigated by incubating scu-PA with varying concentrations of human thrombin, in both the absence and presence of soluble rabbit thrombomodulin.
Munk, G.A.W. de +2 more
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An investigation of the nature of plasminogen activator inhibitor type-I (PAI-I) to improve upon known small molecule inhibitors [PDF]
, 2019 Plasminogen activator inhibitor type-I (PAI-I ) is a serpin superfamily member protein that acts as the major inhibitor of tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA).
Powers, Justin A.
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Dietary fiber linked to decreased inflammation in overweight minority youth [PDF]
, 2015 textObjective: To examine the relationship between diet and inflammation, and adiposity in minority youth. Design and Methods: A cross-sectional analysis of 142 overweight (≥85th BMI percentile) Hispanic and African American adolescents (14-18 y) with ...
Miller, Samantha Jean
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Structural and functional analysis of the interaction between vitronectin and the thrombin-antithrombin pair [PDF]
, 2001 Vitronectin is a multifunctional glycoprotein found both in the circulation and in the extracellular matrix. Circulating vitronectin is in monomeric form while matrix and tissue associated vitronectin tend to form multimers. Interacts with a wide variety
Oguz-Ozen, Secil
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Investigations into the fibrinolytic system and haptoglobin types in certain hereditary and acquired haemostatic disorders and the presence of circulating anticoagulants in such states [PDF]
, 1963 I THE FIBRINOLYTIC SYSTEM: A review of the literature is presented together with an evaluation of the present methods for the measurement of its parameters.The methods adopted in the course of this study include (l) the heated fibrin plate for the ...
Kamel, Karim
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The Rho-activating CNF1 toxin from pathogenic E. coli: A risk factor for human cancer development? [PDF]
, 2008 Nowadays, there is increasing evidence that some pathogenic bacteria can contribute to specific stages of cancer development. The concept that bacterial infection could be involved in carcinogenesis acquired a widespread interest with the discovery that ...
Fabbri, Alessia +2 more
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Pharmacological myeloperoxidase (MPO) inhibition in an obese/hypertensive mouse model attenuates obesity and liver damage, but not cardiac remodeling [PDF]
, 2019 Lifestyle factors are important drivers of chronic diseases, including cardiovascular syndromes, with low grade inflammation as a central player. Attenuating myeloperoxidase (MPO) activity, an inflammatory enzyme associated with obesity, hypertension and
de Boer, Rudolf A +6 more
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ANIMAL VENOM FOR TREATING BREAST CANCER [PDF]
, 2014 Breast cancer is one of the most common malignancies found in women and is associated with increased mortality in advanced disease. With the use of improved screening techniques and improvisation in treatment, 89% of the women diagnosed with breast ...
Ahluwalia, Sanchita, Shah, Nakul
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Diacetyloxyl derivatization of the fibroblast growth factor inhibitor dobesilate enhances its anti-inflammatory, anti-angiogenic and anti-tumoral activities [PDF]
, 2015 Dobesilate (2,5-dihydroxyphenyl sulfonate, DHPS) was recently identified as the most potent member of a family of fibroblast growth factor (FGF) inhibitors headed by gentisic acid, one of the main catabolites of aspirin.
Javier Angulo +7 more
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European Journal of Biochemistry, 2003 Plasminogen activator inhibitor‐1 (PAI‐1) belongs to the serpin family of serine proteinase inhibitors. Serpins inhibit their target proteinases by an ester bond being formed between the active site serine of the proteinase and the P1 residue of the reactive centre loop (RCL) of the serpin, followed by insertion of the RCL into β‐sheet A of the serpin.
Bødker, Julie S. +5 more
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