Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy [PDF]
Clinics, 2018 Platelet activating factor is a lipid mediator of inflammation, and in recent decades, it has emerged as an important factor in tumor outcomes. Platelet activating factor acts by specific binding to its receptor, which is present in both tumor cells and ...
Ildefonso Alves da Silva Junior +3 more
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Platelet-Activating Factor Receptor Ligands Protect Tumor Cells from Radiation-Induced Cell Death [PDF]
Frontiers in Oncology, 2018 Irradiation generates oxidized phospholipids that activate platelet-activating factor receptor (PAFR) associated with pro-tumorigenic effects. Here, we investigated the involvement of PAFR in tumor cell survival after irradiation. Cervical cancer samples
Ildefonso Alves da Silva-Junior +4 more
doaj +5 more sources
Systemic Chemotherapy Is Modulated by Platelet-Activating Factor-Receptor Agonists [PDF]
Mediators of Inflammation, 2015 Chemotherapy is used to treat numerous cancers including melanoma. However, its effectiveness in clinical settings is often hampered by various mechanisms.
Ravi P. Sahu +2 more
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Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor [PDF]
Nature Communications, 2022 The functional consequence of G protein-coupled receptor oligomerization remains debated. Here the authors show that platelet-activating factor receptor oligomerization enhances G protein coupling, and restrains β-arrestin recruitment and internalization.
Junke Liu +11 more
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Nuclear localization of platelet-activating factor receptor controls retinal neovascularization. [PDF]
Cell Discov, 2016 AbstractPlatelet-activating factor (PAF) is a pleiotropic phospholipid with proinflammatory, procoagulant and angiogenic actions on the vasculature. We and others have reported the presence of PAF receptor (Ptafr) at intracellular sites such as the nucleus.
Bhosle VK +12 more
europepmc +6 more sources
A Possible Role for Platelet-Activating Factor Receptor in Amyotrophic Lateral Sclerosis Treatment [PDF]
Frontiers in Neurology, 2018 Amyotrophic lateral sclerosis (ALS) is the third most prevalent neurodegenerative disease affecting upper and lower motor neurons. An important pathway that may lead to motor neuron degeneration is neuroinflammation.
Marcelo R. S. Briones +6 more
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Dissecting Bacterial Cell Wall Entry and Signaling in Eukaryotic Cells: an Actin-Dependent Pathway Parallels Platelet-Activating Factor Receptor-Mediated Endocytosis [PDF]
mBio, 2017 The Gram-positive bacterial cell wall (CW) peptidoglycan-teichoic acid complex is released into the host environment during bacterial metabolism or death.
Lip Nam Loh +2 more
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Platelet-Activating Factor-Receptor and Tumor Immunity. [PDF]
JSM Cell Dev Biol, 2014 First described in 1972 by Benveniste and colleagues, platelet-activating factor (PAF) remains one of the potent phospholipid known to date. The role of PAF produced enzymatically in mediating diverse biological and pathophysiological processes including inflammatory and allergic diseases and cancers in response to various stimuli has been extensively ...
Sahu RP, Konger RL, Travers JB.
europepmc +5 more sources
TNFα promotes mucosal wound repair through enhanced platelet activating factor receptor signaling in the epithelium. [PDF]
Mucosal Immunol, 2019 Pathobiology of several chronic inflammatory disorders, including ulcerative colitis and Crohn’s disease is related to intermittent, spontaneous injury/ulceration of mucosal surfaces.
Birkl D +12 more
europepmc +2 more sources
Macrophage Derived Platelet Activating Factor Implicated in the Resolution Phase of Gouty Inflammation [PDF]
International Journal of Inflammation, 2014 Human blood derived in vitro differentiated monocytes or macrophages are a population of cells which have been investigated over the years to determine the role these cells play in the resolution phase of gout.
Darshna Yagnik
doaj +3 more sources