Systemic Chemotherapy Is Modulated by Platelet-Activating Factor-Receptor Agonists [PDF]
Mediators of Inflammation, 2015 Chemotherapy is used to treat numerous cancers including melanoma. However, its effectiveness in clinical settings is often hampered by various mechanisms.
Ravi P. Sahu +2 more
doaj +5 more sources
Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor [PDF]
Nature Communications, 2022 The functional consequence of G protein-coupled receptor oligomerization remains debated. Here the authors show that platelet-activating factor receptor oligomerization enhances G protein coupling, and restrains β-arrestin recruitment and internalization.
Junke Liu +11 more
doaj +2 more sources
Macrophage Derived Platelet Activating Factor Implicated in the Resolution Phase of Gouty Inflammation [PDF]
International Journal of Inflammation, 2014 Human blood derived in vitro differentiated monocytes or macrophages are a population of cells which have been investigated over the years to determine the role these cells play in the resolution phase of gout.
Darshna Yagnik
doaj +3 more sources
Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy [PDF]
Clinics, 2018 Platelet activating factor is a lipid mediator of inflammation, and in recent decades, it has emerged as an important factor in tumor outcomes. Platelet activating factor acts by specific binding to its receptor, which is present in both tumor cells and ...
Ildefonso Alves da Silva Junior +3 more
doaj +2 more sources
A Novel Platelet-Activating Factor Receptor Antagonist Inhibits Choroidal Neovascularization and Subretinal Fibrosis. [PDF]
PLoS ONE, 2013 Choroidal neovascularization (CNV) is a critical pathogenesis in age-related macular degeneration (AMD), the most common cause of blindness in developed countries.
Han Zhang +6 more
doaj +3 more sources
Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]
Journal of Occupational Medicine and Toxicology, 2008 Background Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
Groneberg David A +3 more
doaj +5 more sources
Bovine Respiratory Syncytial Virus Enhances the Adherence of Pasteurella multocida to Bovine Lower Respiratory Tract Epithelial Cells by Upregulating the Platelet-Activating Factor Receptor [PDF]
Frontiers in Microbiology, 2020 Coinfection by bovine respiratory syncytial virus (BRSV) and Pasteurella multocida (PM) frequently has been observed in cattle that develop severe pneumonia.
Putu Eka Sudaryatma +13 more
doaj +2 more sources
A Possible Role for Platelet-Activating Factor Receptor in Amyotrophic Lateral Sclerosis Treatment [PDF]
Frontiers in Neurology, 2018 Amyotrophic lateral sclerosis (ALS) is the third most prevalent neurodegenerative disease affecting upper and lower motor neurons. An important pathway that may lead to motor neuron degeneration is neuroinflammation.
Marcelo R. S. Briones +6 more
doaj +2 more sources
Platelet-Activating Factor Receptor Ligands Protect Tumor Cells from Radiation-Induced Cell Death [PDF]
Frontiers in Oncology, 2018 Irradiation generates oxidized phospholipids that activate platelet-activating factor receptor (PAFR) associated with pro-tumorigenic effects. Here, we investigated the involvement of PAFR in tumor cell survival after irradiation. Cervical cancer samples
Ildefonso Alves da Silva-Junior +4 more
doaj +2 more sources
Inhibitory Effects of Phylligenin and Quebrachitol Isolated from Mitrephora vulpina on Platelet Activating Factor Receptor Binding and Platelet Aggregation [PDF]
Molecules, 2010 Phylligenine, together with quebrachitol, stigmasterol and two aporphine alkaloids—oxoputerine and liriodenine—were isolated from the twigs of Mitrephora vulpina C.E.C. Fisch.
Khozirah Shaari +3 more
doaj +2 more sources