Results 11 to 20 of about 433,927 (377)

Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells [PDF]

Journal of experimental & clinical cancer research : CR, 2014
We previously identified platelet-activating factor receptor (PAFR) as being overexpressed in ovarian cancer and found that its ligand PAF evoked EGFR phosphorylation using the phospho-antibody microarray. Epidermal growth factor receptor (EGFR) are also
Yi Yu, Ming-xing Zhang, Xiaoyan Zhang, Q. Cai, Zhiling Zhu, Wei Jiang, Congjian Xu   +6 more
semanticscholar   +3 more sources

Cigarette smoke promotes COPD by activating platelet-activating factor receptor and inducing neutrophil autophagic death in mice. [PDF]

Oncotarget, 2017
Neutrophils are the most important effector cells during the development of chronic obstructive pulmonary disease (COPD). Although neutrophil elastase is critical in cigarette smoke (CS)-induced lung parenchyma, the mechanism by which CS triggers ...
Lv XX, Liu SS, Li K, Cui B, Liu C, Hu ZW.   +5 more
europepmc   +2 more sources

Bovine Respiratory Syncytial Virus Enhances the Adherence of Pasteurella multocida to Bovine Lower Respiratory Tract Epithelial Cells by Upregulating the Platelet-Activating Factor Receptor [PDF]

Frontiers in Microbiology, 2020
Coinfection by bovine respiratory syncytial virus (BRSV) and Pasteurella multocida (PM) frequently has been observed in cattle that develop severe pneumonia.
Putu Eka Sudaryatma, Putu Eka Sudaryatma, Akatsuki Saito, Akatsuki Saito, Akatsuki Saito, Hirohisa Mekata, Hirohisa Mekata, Meiko Kubo, Watcharapong Fahkrajang, Eugene Mazimpaka, Eugene Mazimpaka, Tamaki Okabayashi, Tamaki Okabayashi, Tamaki Okabayashi   +13 more
doaj   +2 more sources

Dysfunctional epileptic neuronal circuits and dysmorphic dendritic spines are mitigated by platelet-activating factor receptor antagonism. [PDF]

Sci Rep, 2016
Temporal lobe epilepsy or limbic epilepsy lacks effective therapies due to a void in understanding the cellular and molecular mechanisms that set in motion aberrant neuronal network formations during the course of limbic epileptogenesis (LE).
Musto AE, Rosencrans RF, Walker CP, Bhattacharjee S, Raulji CM, Belayev L, Fang Z, Gordon WC, Bazan NG.   +8 more
europepmc   +2 more sources

Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]

Journal of Occupational Medicine and Toxicology, 2008
Background Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
Groneberg David A, Staats Petra, Schmidt Rene, Wagner Ulrich   +3 more
doaj   +5 more sources

Airway epithelial platelet-activating factor receptor expression is markedly upregulated in chronic obstructive pulmonary disease

International Journal of COPD, 2014
Shakti Dhar Shukla,1,* Sukhwinder Singh Sohal,1,* Malik Quasir Mahmood,1 David Reid,2 Hans Konrad Muller,1 Eugene Haydn Walters1 1NHMRC Centre for Research Excellence for Chronic Respiratory Disease and Lung Ageing, School of Medicine, University of ...
Shukla SD, Sohal SS, Mahmood MQ, Reid D, Muller HK, Walters EH   +5 more
doaj   +2 more sources

Platelet-Activating Factor Disrupts the Nasal Epithelial Barrier Independently of the Platelet-Activating Factor Receptor Pathway. [PDF]

Allergy Asthma Immunol Res
Platelet-activating factor (PAF) mediates nasal congestion and rhinorrhea by affecting vascular permeability, but the underlying mechanisms remain unclear. Here, we sought to explore the effect of PAF on the nasal epithelial barrier in chronic rhinosinusitis with nasal polyps (CRSwNP).Human nasal epithelial cells (hNECs) were pre-treated with Apafant ...
Tan J, Han X, Li S, Wang Q, Zhao L, Li Y, Duan S, Zhang L.   +7 more
europepmc   +3 more sources

Upregulated pneumococcal adhesion molecule (platelet-activating factor receptor) may predispose COPD patients to community-acquired pneumonia [PDF]

International Journal of COPD, 2017
Shakti Dhar Shukla,1,2 Philip M Hansbro,1,2 Eugene Haydn Walters3 1School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, 2Hunter Medical Research Institute, New Lambton Heights, NSW, 3School of Medicine, University of ...
Shukla SD, Hansbro PM, Walters EH
doaj   +2 more sources

Platelet-activating factor receptor (PAFR) regulates neuronal maturation and synaptic transmission during postnatal retinal development [PDF]

Frontiers in Cellular Neuroscience
IntroductionPlatelet-activating factor (PAF), PAF receptor (PAFR), and PAF- synthesis/degradation systems are involved in essential CNS processes such as neuroblast proliferation, differentiation, migration, and synaptic modulation.
Barbara Dalmaso, Andre Mauricio Passos Liber, Andre Mauricio Passos Liber, Dora Fix Ventura, Sonia Jancar, Carolina Beltrame Del Debbio   +5 more
doaj   +2 more sources

Platelet Activating Factor Receptor Exaggerates Microglia-Mediated Microenvironment by IL10-STAT3 Signaling: A Novel Potential Biomarker and Target for Diagnosis and Treatment of Alzheimer's Disease. [PDF]

Front Aging Neurosci, 2022
Liu J, Jiao L, Zhong X, Yao W, Du K, Lu S, Wu Y, Ma T, Tong J, Xu M, Jiang W, Wang Y, He M, Xin W, Liu M.   +14 more
europepmc   +3 more sources