Results 101 to 110 of about 7,167 (241)
bioRxiv, 2022 Background In-depth knowledge of the cellular and molecular composition of dental pulp (DP) and the crosstalk between DP cells that drive tissue homeostasis are not well understood.
Natnicha Jiravejchakul +8 more
semanticscholar +1 more source
Assessing Aβ‐independent effects of Module 42 on immune function in vitro
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION A deep multi‐omic analysis of post mortem human brains has identified a new co‐expression protein network – Module 42 (M42), strongly corelated with Alzheimer's disease (AD) pathology. M42 comprises 32 transmembrane and extracellular matrix (ECM)‐associated proteins, including the amyloid precursor protein (APP) and apolipoprotein
Ishita Ajith +7 more
wiley +1 more source
Endogenous pleiotrophin and midkine regulate LPS-induced glial responses [PDF]
Neuroscience Letters, 2018 Pleiotrophin (PTN) and Midkine (MK) are two growth factors that modulate neuroinflammation. PTN overexpression in the brain prevents LPS-induced astrocytosis in mice but potentiates microglial activation. The modest astrocytic response caused by a low dose of LPS (0.5mg/kg) is blocked in the striatum of MK-/- mice whereas microglial response is ...
Rosalía, Fernández-Calle +6 more
openaire +2 more sources
Targeting Receptor-Type Protein Tyrosine Phosphatases with Biotherapeutics: Is Outside-in Better than Inside-Out? [PDF]
, 2018 Protein tyrosine phosphatases (PTPs), of the receptor and non-receptor classes, are key signaling molecules that play critical roles in cellular regulation underlying diverse physiological events.
Alastair Barr +4 more
core +2 more sources
The Interaction between Chondroitin Sulfate and Dermatan Sulfate Tetrasaccharides and Pleiotrophin
International Journal of Molecular Sciences, 2022 Pleiotrophin (PTN) is a neurotrophic factor that participates in the development of the embryonic central nervous system (CNS) and neural stem cell regulation by means of an interaction with sulfated glycosaminoglycans (GAGs). Chondroitin sulfate (CS) is
M. García-Jiménez +3 more
semanticscholar +1 more source
Molecular Study of Interactions between Hematopoietic Stem Cells and Stromal Cells [PDF]
, 2002 Multipotent hematopoietic stem cells (HSCs) are progenitors of all types of hematopoietic cells, and the efficient isolation and propagation of HSCs will significantly enhance our ability to manage many human disorders with bone marrow transplantation ...
Heard, Amanda +8 more
core
Midkine mediates intercellular crosstalk between drug-resistant and drug sensitive neuroblastoma cells in vitro and in vivo [PDF]
, 2013 Resistance to cytotoxic agents has long been known to be a major limitation in the treatment of human cancers. Although many mechanisms of drug resistance have been identified, chemotherapies targeting known mechanisms have failed to lead to effective ...
Chou, Pauline M +9 more
core +3 more sources
The Journal of Physiology, Volume 604, Issue 4, Page 1646-1681, 15 February 2026.Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker +2 more
wiley +1 more source
Role of High-Mobility Group Box-1 in Liver Pathogenesis [PDF]
, 2019 High-mobility group box 1 (HMGB1) is a highly abundant DNA-binding protein that can relocate to the cytosol or undergo extracellular release during cellular stress or death. HMGB1 has a functional versatility depending on its cellular location.
Huda, Nazmul +3 more
core +1 more source
Advanced Science, Volume 12, Issue 45, December 4, 2025.This study elucidates macrophage‐induced orbital fibrosis in TED via the GAS6‐AXL pathway, a treatment‐resistant disorder lacking non‐surgical therapies. Using a novel patient cell‐derived orthotopic animal model of orbital fibrosis for TED, we repurpose an existing fibrosis therapy, addressing the absence of stable models and offering a potential ...
Lu Cheng +14 more
wiley +1 more source