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Cell, 1999 In Drosophila, plexin A is a functional receptor for semaphorin-1a. Here we show that the human plexin gene family comprises at least nine members in four subfamilies. Plexin-B1 is a receptor for the transmembrane semaphorin Sema4D (CD100), and plexin-C1
Luca Tamagnone +2 more
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Emerging role of plexins signaling in glioma progression and therapy
Cancer Letters, 2018 Gliomas are highly invasive brain tumors with increased resistance to chemotherapy and high recurrence rate. Neoplastic cells commonly infiltrate into the surrounding tissue even at low grade tumors.
Efthalia Angelopoulou +1 more
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Semaphorins and plexins as therapeutic targets
Nature Reviews Drug Discovery, 2014Semaphorins are membrane-bound or diffusible factors that regulate key cellular functions and are involved in cell-cell communication. Most of the effects of semaphorins are mediated by plexins. Work over the past decade has revealed crucial functions of the semaphorin-plexin system in mammalian physiology. It has also become clear that semaphorins and
Thomas Worzfeld +2 more
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Immune plexins and semaphorins: old proteins, new immune functions
Protein and Cell, 2013 Plexins and semaphorins are a large family of proteins that are involved in cell movement and response. The importance of plexins and semaphorins has been emphasized by their discovery in many organ systems including the nervous (Nkyimbeng-Takwi and ...
Ting, Jenny +5 more
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Neuron, 2001 The Plexin family of transmembrane proteins appears to function as repulsive receptors for most if not all Semaphorins. Here, we use genetic and biochemical analysis in Drosophila to show that the transmembrane protein Off-track (OTK) associates with ...
Luca Tamagnone +2 more
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Role of semaphorins, neuropilins and plexins in cancer progression
Cancer LettersProgress in understanding nervous system-cancer interconnections has emphasized the functional role of semaphorins (SEMAs) and their receptors, neuropilins (NRPs) and plexins (PLXNs), in cancer progression.
Paloma Bragado
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Cancers, 2020 Class-3 semaphorins (SEMA3s), initially characterized as axon guidance cues, have been recognized as key regulators for immune responses, angiogenesis, tumorigenesis and drug responses.
Xiaoli Zhang, , Lang Li
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Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains
Biochemical and Biophysical Research Communications, 2003Semaphorin 3A (Sema3A) is a member of semaphorins and functions as an axonal repulsive guidance molecule. Neuropilin-1 and plexin-As form receptor complexes for Sema3A and plexin-As are thought to initiate the intracellular signaling cascade. However, the molecule by which plexin-As transduce their signal is not well understood.
Hiroshi, Usui +3 more
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The expression of plexins during mouse embryogenesis
Gene Expression Patterns, 2005Plexins are large transmembrane proteins that are receptors for semaphorins, either alone or in a complex with neuropilin-1 or -2. Nine different mouse plexins have been found: Plexin-A1-4, -B1-3, -C1 and -D1. The expression and function of plexins in non-neuronal tissues has been poorly characterized, although Plexin-A1 has been shown to have a role ...
Tiina Immonen
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Plexins are partners for neuropilins
Science Signaling, 1999Membrane-bound and secreted semaphorins regulate a number of cell adhesion processes including axon guidance in the nervous system. However, little is known about the receptors to which they bind. Although neuropilins bind to secreted class 3 semaphorins (Sema3), it is thought that a coreceptor might be required to transduce Sema3 signals
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