Results 171 to 180 of about 2,365 (188)

Plexins: axon guidance and signal transduction

Cellular and Molecular Life Sciences, 2005
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as semaphorins, ephrins and netrin. Plexins function as receptors for the repulsive axonal guidance molecules semaphorins.
M, Negishi, I, Oinuma, H, Katoh
openaire   +2 more sources

More than nervous: The emerging roles of plexins

Differentiation, 2012
Plexins are the receptors for semaphorins, a large family of axon guidance cues. Accordingly, the role of plexins in the development of the nervous system was the first to be acknowledged. However, the expression of plexins is not restricted to neuronal cells, and recent research has been increasingly focused on the roles of plexin-semaphorin ...
Nina Perala, Tiina Immonen
exaly   +3 more sources

Identification of Plexin Family Molecules in Mice

Biochemical and Biophysical Research Communications, 1996
By screening of E17.5 mouse brain cDNA libraries, we isolated two cDNAs encoding new plexin-like proteins. Sequencing revealed that these two proteins were type 1 membrane proteins which showed over 60% identity at the amino acid level to mouse plexin 1.
T, Kameyama, Y, Murakami, F, Suto, A, Kawakami, S, Takagi, T, Hirata, H, Fujisawa   +6 more
openaire   +2 more sources

The evolving role of semaphorins and plexins in the immune system: Plexin-A1 regulation of dendritic cell function

Immunologic Research, 2008
Semaphorin and plexin proteins were originally identified for their important axon guidance regulation. In recent years, their role within the immune system has been discovered. Semaphorins are considered the ligands to the plexin receptors, and together, they mediate cell-cell communication.
Brian P, O'Connor, Jenny P-Y, Ting
openaire   +2 more sources

The Function of Neuropilin/Plexin Complexes

2002
Neuropilins bind the secreted class 3 semaphorins with high affinity but require a member of the plexin family to form receptors that are able to activate downstream signal transduction cascades. In this receptor complex neuropilins act as the ligand-binding subunit while plexins function as the signal-transducing subunit in the induction of ...
openaire   +2 more sources

Domains in plexins: links to integrins and transcription factors

Trends in Biochemical Sciences, 1999
P. B., B. S. and T. D. are supported by the EU and the DFG; T. A. S. is supported by the NIH.
Bork, Peer, Doerks, Tobias, Springer, Timothy A., Snel, Berend   +3 more
openaire   +3 more sources

Repulsive Plexin Signaling Mediators

Science Signaling, 2001
Semaphorins mediate axon repulsion through interactions with their receptors the Plexins. Two papers now identify some of the signaling elements in axon guidance that are mediated by Plexin A and Plexin B: Hu et al. investigated signaling from Plexin B to two cytoskeletal regulators, the Rac and Rho guanosine ...
openaire   +2 more sources

Semaphorins and Plexins in central nervous system patterning: the key to it all?

Current Opinion in Neurobiology, 2021
Greta Limoni, Mathieu Niquille
exaly  

Immunological functions of the neuropilins and plexins as receptors for semaphorins

Nature Reviews Immunology, 2013
Atsushi Kumanogoh, Hitoshi Kikutani, Kumanogoh Atsushi   +2 more
exaly  

Interplay between scatter factor receptors and B plexins controls invasive growth

Oncogene, 2004
Simona Corso, Paolo M Comoglio, Silvia Giordano   +2 more
exaly