Results 111 to 120 of about 998,979 (405)
Mitochondrial Regulation in Pluripotent Stem Cells [PDF]
Cell Metabolism, 2013 Due to their fundamental role in energy production, mitochondria have been traditionally known as the powerhouse of the cell. Recent discoveries have suggested crucial roles of mitochondria in the maintenance of pluripotency, differentiation, and reprogramming of induced pluripotent stem cells (iPSCs).
Fei Yi +5 more
openaire +3 more sources
Autonomous Control of Extrusion Bioprinting Using Convolutional Neural Networks
Advanced Functional Materials, EarlyView.This work presents a novel computer vision system for high‐fidelity monitoring of extrusion‐based bioprinting and a correction system utilizing convolutional neural networks for error mitigation. This system has demonstrated high detection accuracy and extrusion correction abilities that advance the state of the art toward accelerated printing ...
Daniel Kelly +4 more
wiley +1 more source
From Chemically to Physically Induced Pluripotency in Stem Cell [PDF]
arXiv, 2015 A quantum model on the chemically and physically induced pluripotency in stem cells is proposed. Based on the conformational Hamiltonian and the idea of slow variables (molecular torsions) slaving fast ones the conversion from the differentiate state to pluripotent state is defined as the quantum transition between conformational states.
arxiv
Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species. [PDF]
, 2013 Cells are fundamental units of life, but little is known about evolution of cell states. Induced pluripotent stem cells (iPSCs) are once differentiated cells that have been re-programmed to an embryonic stem cell-like state, providing a powerful platform
Chen, CC +5 more
core +2 more sources
Advanced Functional Materials, EarlyView.Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim +8 more
wiley +1 more source
Data in Brief, 2021 Integration-free induced pluripotent stem cells from related human donors’ exhibit great potential to the ongoing development of organ models. Blood cells from two different human donors were isolated, purified and reprogrammed into induced pluripotent ...
Anja Patricia Ramme +4 more
doaj
Our Bodies, Our Cells: FDA Regulation of Autologous Adult Stem Cell Therapies [PDF]
, 2013 Stem cells have been an endless source of fascination and controversy since Dolly the sheep was cloned in 1996. This month’s announcement of a cloned human embryo from a single skin cell came on the heels of Sir John B. Gurdon and Dr.
Chirba, Mary Ann, Noble, Alice
core
Establishment of pluripotent cell lines from vertebrate species - Present status and future prospects [PDF]
, 1999 Pluripotent embryonic stem (ES) cells are undifferentiated cell lines derived from early embryos and are capable of unlimited undifferentiated proliferation in vitro.
Prelle, Katja +4 more
core +1 more source
Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development.
Physiological Reviews, 2019 The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same genetic code as the zygote, and that activating parts of this code are sufficient to reprogram the cell to an early developmental state.
Peter Karagiannis +13 more
semanticscholar +1 more source
Micro-management of pluripotent stem cells
Protein & Cell, 2014 Embryonic and induced pluripotent stem cells (ESCs and iPSCs) hold great promise for regenerative medicine. The therapeutic application of these cells requires an understanding of the molecular networks that regulate pluripotency, differentiation, and de-differentiation.
Xi-Wen Wang, Wen-Ting Guo, Yangming Wang
openaire +3 more sources