Results 111 to 120 of about 959,542 (406)

Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development.

Physiological Reviews, 2019
The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same genetic code as the zygote, and that activating parts of this code are sufficient to reprogram the cell to an early developmental state.
Peter Karagiannis, Kazutoshi Takahashi, M. Saito, Y. Yoshida, K. Okita, Akira Watanabe, H. Inoue, J. Yamashita, Masaya Todani, M. Nakagawa, M. Osawa, Yoshimi Yashiro, S. Yamanaka, K. Osafune   +13 more
semanticscholar   +1 more source

Tunable Synthetic Hydrogel Modulates Hepatic Lineage Specification of Human Liver Organoid

Advanced Functional Materials, EarlyView.
In this study, a synthetic hydrogel is reported that supports the formation of hiPSC‐derived human liver organoids (HLOs). Hepatic lineage specification can be modulated via conjugation of RGD peptide to hydrogel: RGD‐conjugated hydrogels promote cholangiocyte differentiation, whereas RGD‐free hydrogels favor hepatocyte commitment of HLO cells.
Lei Wang, Lasse Riediger, Qi Rao, Xun Xu, Yan Nie, Yiduo Zhou, Junyao Zhang, Peng Tang, Weiwei Wang, Frank Tacke, Adrien Guillot, Ludovic Vallier, Irene Talon, Wenzhong Li, Yi‐An Yang, Rainer Haag, Nan Ma   +16 more
wiley   +1 more source

Effects of reprogramming on genomic imprinting and the application of pluripotent stem cells

Stem Cell Research, 2019
Pluripotent stem cells are considered to be the ideal candidates for cell-based therapies in humans. In this regard, both nuclear transfer embryonic stem (ntES) cells and induced pluripotent stem (iPS) cells are particularly advantageous because patient ...
Xiajun Li, Max Jiahua Li, Yang Yang, Yun Bai   +3 more
doaj   +1 more source

Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells

Journal of experimental & clinical cancer research : CR, 2020
Human pluripotent embryonic stem cells have two special features: self-renewal and pluripotency. It is important to understand the properties of pluripotent stem cells and reprogrammed stem cells.
Kenly Wuputra, C. Ku, Deng-Chyang Wu, Ying-Chu Lin, Shigeo Saito, K. Yokoyama   +5 more
semanticscholar   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Micro-management of pluripotent stem cells

Protein & Cell, 2014
Embryonic and induced pluripotent stem cells (ESCs and iPSCs) hold great promise for regenerative medicine. The therapeutic application of these cells requires an understanding of the molecular networks that regulate pluripotency, differentiation, and de-differentiation.
Xi-Wen Wang, Wen-Ting Guo, Yangming Wang
openaire   +3 more sources

Systematic optimization of human pluripotent stem cells media using Design of Experiments. [PDF]

, 2015
Human pluripotent stem cells (hPSC) are used to study the early stages of human development in vitro and, increasingly due to somatic cell reprogramming, cellular and molecular mechanisms of disease.
Chailangkarn, Thanathom, Marinho, Paulo A, Muotri, Alysson R   +2 more
core   +1 more source

Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells attenuate limb ischemia by promoting angiogenesis in mice

Stem cell research & therapeutics, 2015
Introduction‘Patient-specific’ induced pluripotent stem cells (iPSCs) are attractive because they can generate abundant cells without the risk of immune rejection for cell therapy.
Guo-wen Hu, Qing Li, X. Niu, Bin Hu, Juan Liu, Shumin Zhou, Shang-Chun Guo, Haili Lang, Changqing Zhang, Yang Wang, Zhifeng Deng   +10 more
semanticscholar   +1 more source

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

Big bottlenecks in cardiovascular tissue engineering. [PDF]

, 2018
Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of ...
Abilez, Oscar J, Huang, Ngan F, Morris, Viola B, Nakayama, Karina H, Pardon, Gaspard, Pruitt, Beth L, Sayed, Nazish, Serpooshan, Vahid, Wu, Joseph C, Wu, Sean M, Yoon, Young-Sup, Zhang, Jianyi   +11 more
core