Results 111 to 120 of about 201,548 (273)

Human Pluripotent Stem Cells: Science Fiction Poses No Immediate Dangers [PDF]

, 2000
Curt I. Civin
openalex   +1 more source

Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function

Advanced Science, EarlyView.
CYTOR is a pro‐myogenic ncRNA in skeletal muscle. Here, chemical probing of CYTOR, coupled with functional cellular assays identifies exon 2 as an independent myogenic RNA domain. Chemical engineering of CYTOR exon 2 RNA improves pharmacologic properties, including RNA stability and cell‐autonomous immunogenicity.
Zeinabou Niasse‐Sy, Bo Zhao, Ajda Lenardič, Huyen Thuc Tran Luong, Ori Bar‐Nur, Johan Auwerx, Martin Wohlwend   +6 more
wiley   +1 more source

Correction of the Allan-Herndon-Dudley syndrome-causing SLC16A2 mutation G401R in a patient derived hiPSC line

Stem Cell Research
The X-linked Allan-Herndon-Dudley syndrome (AHDS) is a genetic disorder characterized by severe psychomotor impairment, resulting from mutations in the SLC16A2 gene, which encodes the thyroid hormone transporter MCT8 (monocarboxylate transporter 8 ...
Katarzyna A. Ludwik, Robert Opitz, Sabine Jyrch, Matthias Megges, Peter Kühnen, Harald Stachelscheid   +5 more
doaj  

Clonogenic analysis reveals reserve stem cells in postnatal mammals: I. Pluripotent mesenchymal stem cells [PDF]

, 2001
Warren Young, Cécile Duplaà, T. Michele Young, Julie A. Floyd, Michelle L. Reeves, Kathryn H. Davis, Greg J. Mancini, Mark E. Eaton, John Hill, Karen Thomas, Troy Austin, Chris Edwards, Jeremy Cuzzourt, Amar Parikh, Jaime Groom, John Hudson, Asa C. Black   +16 more
openalex   +1 more source

NF2 is Essential for Human Endoderm Development

Advanced Science, EarlyView.
This study demonstrates that NF2, moesin‐ezrin‐radixin like (MERLIN) tumor suppressor (NF2) is essential for human endoderm formation. NF2 knockout human induced pluripotent stem cells fail to form endoderm both in vitro and in vivo due to yes‐associated protein 1 (YAP1) nuclear translocation, redirecting differentiation toward myofibroblast‐like cells.
Minjin Jeong, Dongjun Han, Preetida Bhetariya, D. Bradley Welling, Miodrag Stojkovic, Konstantina M. Stankovic   +5 more
wiley   +1 more source

Impaired Development of T Lymphoid Precursors from Pluripotent Hematopoietic Stem Cells in New Zealand Black Mice [PDF]

, 2002
Yoshiko Hashimoto, Encarnación Montecino-Rodriguez, M. Eric Gershwin, Kenneth Dorshkind   +3 more
openalex   +1 more source

SIRT3‐Mediated Deacetylation of DRP1K711 Prevents Mitochondrial Dysfunction in Parkinson's Disease

Advanced Science, EarlyView.
SIRT3‐mediated deacetylation of DRP1 at K711 resists mitochondrial dysfunction and DA neuronal death in PD, uncovering a treatment target. Abstract Dysregulation of mitochondrial dynamics is a key contributor to the pathogenesis of Parkinson's disease (PD).
Ye Xi, Kai Tao, Xiaomin Wen, Dayun Feng, Zifan Mai, Hui Ding, Honghui Mao, Mingming Wang, Qian Yang, Jie Xiang, Jie Zhang, Shengxi Wu   +11 more
wiley   +1 more source

MicroRNA‐433‐3p enhances chemosensitivity of glioma to cisplatin by downregulating NR5A2

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
miR‐433‐3p mediated the ability of NR5A2 to regulate the malignant behavior of glioma cells Abstract Objective We attempted to investigate influence of microRNA‐433‐3p on malignant progression of glioma and identify its molecular mechanism, thus laying groundwork for glioma management.
Jun Li, Jingshun Gu, Juntong Wang, Aiwu You, Yuyan Zhang, Guomin Rao, Shuang Li, Xuehua Ge, Kun Zhang, Dongchun Wang   +9 more
wiley   +1 more source

Biochemical properties of a keratan sulphate/chondroitin sulphate proteoglycan expressed in primate pluripotent stem cells* [PDF]

, 2002
Susan J. Cooper, William Bennett, Jéssica Andrade, Benjamin Reubinoff, James Thomson, Martín F. Pera   +5 more
openalex   +1 more source

hESCs‐derived Organoids Achieve Liver Zonation Features through LSEC Modulation

Advanced Science, EarlyView.
This article addresses the absence of zonation features in current organoid models by co‐culturing human embryonic stem cell‐derived hepatocytes with liver sinusoidal endothelial cells exhibiting distinct zonal characteristics. It demonstrates that differential WNT2 signaling from endothelial cells modulates hepatocyte zonation and metabolic functions,
Yuying Zhang, Chenyan Huang, Lei Sun, Lyu Zhou, Yudi Niu, Kaini Liang, Bingjie Wu, Peng Zhao, Zhiqiang Liu, Xiaolin Zhou, Peng Zhang, Jianchen Wu, Jie Na, Yanan Du   +13 more
wiley   +1 more source