Results 11 to 20 of about 39,468 (302)

In situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug delivery [PDF]

International Journal of Pharmaceutics, 2016
This study evaluated the use of Pluronic F127 and Pluronic F68 as excipients for formulating in situ gelling systems for ocular drug delivery. Thermal transitions have been studied in aqueous solutions of Pluronic F127, Pluronic F68 as well as their binary mixtures using differential scanning calorimetry, rheological measurements, and dynamic light ...
Al-Khateb K, Ozhmukhametova EK, Mussin MN, Seilkhanov SK, Rakhypbekov TK, Lau WM, Khutoryanskiy VV   +6 more
openaire   +5 more sources

Purification of Pluronic F-68 for perfluorochemical emulsification

Journal of Pharmacy and Pharmacology, 1989
Abstract A novel technique for purification of Pluronic F-68 has been developed involving passage through a silica-Amberlite resin column. Impurities present in commercial grade Pluronic could be readily removed, as confirmed by analysis of absorption and fluorescence emission bands.
P K, Bentley, S S, Davis, O L, Johnson, K C, Lowe, C, Washington   +4 more
openaire   +3 more sources

Hybrid Thermo-Responsive Polymer Systems and Their Biomedical Applications

Frontiers in Materials, 2020
Targeted and controlled drug delivery employing “smart materials” is a widely investigated field, within which stimuli-responsive polymers, particularly those which are thermo-responsive, have received considerable attention.
Taskeen Sarwan, Pradeep Kumar, Yahya E. Choonara, Viness Pillay   +3 more
doaj   +1 more source

Pluronic as nano-carier for drug delivery systems [PDF]

Nanomedicine Research Journal, 2018
A common approach for building a drug delivery system is to incorporate the drug within the nanocarrier that results in increased solubility, metabolic stability, and improved circulation time.
Abbas Rahdar, Susan kazemi, Faezeh Askari   +2 more
doaj   +1 more source

Dual-Enhanced Pluronic Nanoformulated Methotrexate-Based Treatment Approach for Breast Cancer: Development and Evaluation of In Vitro and In Vivo Efficiency

Pharmaceutics, 2022
Breast cancer is a prevalent tumor and causes deadly metastatic complications. Myriad cancer types, including breast cancer, are effectively treated by methotrexate (MTX).
Amira Mansour, Mohamed Y. Mahmoud, Alaa F. Bakr, Monira G. Ghoniem, Fatima A. Adam, Ibrahim M. El-Sherbiny   +5 more
doaj   +1 more source

Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice [PDF]

, 2001
Polyethylene-glycol (PEG) is a strong inhibitor of colon cancer in rats, and the most potent suppressor of aberrant crypt foci. Nine PEG-like block copolymers were tested in rodents, after an azoxymethane injection.
Peiffer, Ginette, Parnaud, G., Peiffer, G., Parnaud, Géraldine, Taché, Sylviane, Corpet, Denis E.   +5 more
core   +2 more sources

Synthesis and Optimization of Next-Generation Low-Molecular-Weight Pentablock Copolymer Nanoadjuvants

Vaccines, 2023
Polymeric nanomaterials such as Pluronic®-based pentablock copolymers offer important advantages over traditional vaccine adjuvants and have been increasingly investigated in an effort to develop more efficacious vaccines.
Alaric C. Siddoway, Brianna M. White, Balaji Narasimhan, Surya K. Mallapragada   +3 more
doaj   +1 more source

Enhancing Ezetimibe Anticancer Activity Through Development of Drug Nano-Micelles Formulations: A Promising Strategy Supported by Molecular Docking

International Journal of Nanomedicine, 2023
Tarek A Ahmed,1 Ehab MM Ali,2 Abdelsattar M Omar,3 Alshaimaa M Almehmady,1 Khalid M El‐Say1 1Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Kingdom of Saudi Arabia; 2Department of Biochemistry, Faculty of ...
Ahmed TA, Ali EM, Omar AM, Almehmady AM, El‐Say KM   +4 more
doaj  

Honokiol/Magnolol-Loaded Self-Assembling Lecithin-Based Mixed Polymeric Micelles (lbMPMs) for Improving Solubility to Enhance Oral Bioavailability

International Journal of Nanomedicine, 2021
Hong-Liang Lin,1 Wen-Ting Cheng,2 Ling-Chun Chen,3 Hsiu-O Ho,2 Shyr-Yi Lin,4,5 Chien-Ming Hsieh2 1School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, Republic of China; 2School of Pharmacy, College of Pharmacy,
Lin HL, Cheng WT, Chen LC, Ho HO, Lin SY, Hsieh CM   +5 more
doaj  

Improved bioavailability of raloxifene hydrochloride through nasal administration of poly (methyl vinyl ether-co-maleic acid) nanoparticles in ovariectomized rats [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): To improve the low bioavailability of Raloxifene hydrochloride (RH), which is just 2% through oral administration, an in situ mucoadhesive thermoreversible gel loaded with RH nanoparticles was formulated using Pluronic F127.
Ladan Dayani, Jaleh Varshosaz, Mohsen Minaiyan   +2 more
doaj   +1 more source