The Identification of Novel Mutations in ATP-Dependent Protease ClpC1 Assists in the Molecular Diagnosis of Obscured Pyrazinamide-Resistant Tuberculosis Clinical Isolates [PDF]
MicroorganismsPyrazinamide (PZA) is a key component of tuberculosis treatment, with drug resistance (PZAR) primarily related to pncA mutations. However, discordance between phenotypic resistance and conventional pncA-based molecular diagnostics challenges diagnostic ...
H. M. Adnan Hameed +9 more
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Intestinal Fut2 deficiency exacerbated alcohol‐related liver disease by disrupting nicotinamide metabolism [PDF]
Clinical and Translational MedicineBackground Fucosyltransferase 2 (FUT2)‐dependent fucosylation of intestinal epithelial cells is vital for preserving gut barrier integrity and microbial balance.
Liuying Chen +9 more
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Pyrazinamide resistance-conferring mutations in pncA and the transmission of multidrug resistant TB in Georgia [PDF]
BMC Infectious Diseases, 2017 Background The ongoing epidemic of multidrug-resistant tuberculosis (MDR-TB) in Georgia highlights the need for more effective control strategies.
Sarah Sengstake +8 more
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Prevalence and Clinical Implications of Pyrazinamide Resistance in Newly Diagnosed TB Patients in Uganda [PDF]
Infection and Drug ResistanceChristopher Ndawula, Nalumaga Pauline Petra, Fredrickson B Wasswa, Joel Bazira Department of Microbiology, Mbarara University of Science and Technology, Mbarara, 1410, UgandaCorrespondence: Joel Bazira, Email jbazira@must.ac.ugBackground: Globally, 10.8 ...
Ndawula C, Petra NP, Wasswa FB, Bazira J
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Comprehensive evaluation of the MeltPro MTB/PZA assay for prediction of pyrazinamide resistance in multidrug-resistant tuberculosis [PDF]
Microbiology SpectrumResistance to pyrazinamide (PZA) poses significant challenges to tuberculosis (TB) management, and prediction of susceptibility to PZA has been challenging.
Guiqing He +10 more
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Deep learning with photonic neural cellular automata [PDF]
Light: Science & ApplicationsRapid advancements in deep learning over the past decade have fueled an insatiable demand for efficient and scalable hardware. Photonics offers a promising solution by leveraging the unique properties of light.
Gordon H. Y. Li +5 more
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Frontiers in Microbiology, 2021 Pyrazinamide (PZA) is widely used to treat drug-sensitive or multidrug resistance tuberculosis. However, conventional PZA susceptibility tests of clinical isolates are rather difficult because of the requirement of acid pH.
Kun Li +6 more
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Regulation of enteroendocrine cell respiration by the microbial metabolite hydrogen sulfide
Frontiers in Endocrinology, 2023 Endocrine functions of the gut are supported by a scattered population of cells, the enteroendocrine cells (EECs). EECs sense their environment to secrete hormones in a regulated manner.
Pierre Larraufie +5 more
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Scientific Reports, 2021 To study, in young growing rats, the consequences of different levels of dietary protein deficiency on food intake, body weight, body composition, and energy balance and to assess the role of FGF21 in the adaptation to a low protein diet.
Joanna Moro +7 more
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Dopamine Modulates the Processing of Food Odour in the Ventral Striatum
Biomedicines, 2022 Food odour is a potent stimulus of food intake. Odour coding in the brain occurs in synergy or competition with other sensory information and internal signals.
Olivier Rampin +11 more
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