Results 31 to 40 of about 6,468 (198)

Spoligotyping with pncA sequencing strategy conferring the transmission of multidrug-resistant tuberculosis in Egypt

International Journal of Mycobacteriology, 2019
Background: This study explored the genetic diversity of Mycobacterium tuberculosis isolates in Egypt by spoligotyping in combination with pncA gene sequencing, spoNC. Methods: First, isolates were selected from 400 isolates positive for M.
Suzan Ismail, Khaled Al Amry, Galal Aggor, Hoida El Naggar, Salah Selim   +4 more
doaj   +1 more source

A Multinational Analysis of Mutations and Heterogeneity in PZase, RpsA, and PanD Associated with Pyrazinamide Resistance in M/XDR Mycobacterium tuberculosis. [PDF]

, 2017
Pyrazinamide (PZA) is an important first-line drug in all existing and new tuberculosis (TB) treatment regimens. PZA-resistance in M. tuberculosis is increasing, especially among M/XDR cases.
Catanzaro, A, Catanzaro, D, Fink, L, Jackson, RL, Pettigrove, M, Ramirez-Busby, SM, Rodwell, TC, Valafar, F   +7 more
core   +1 more source

Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450 [PDF]

, 2006
Creating artificial protein families affords new opportunities to explore the determinants of structure and biological function free from many of the constraints of natural selection.
Arnold, Frances H., Bloom, Jesse D., Endelman, Jeffrey B., Hiraga, Kaori, Landwehr, Marco, Otey, Christopher R.   +5 more
core   +1 more source

Detecting Mutations in the Mycobacterium tuberculosis Pyrazinamidase Gene pncA to Improve Infection Control and Decrease Drug Resistance Rates in Human Immunodeficiency Virus Coinfection. [PDF]

, 2016
Hospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)-positive patients, as these patients are at heightened risk of developing TB.
Bangsberg, Butler, Campos, Carlton A. Evans, Caviedes, Daniela E. Kirwan, David A. J. Moore, Dooley, Eduardo Ticona, Escombe, Escombe, Evans, Franzblau, Hannan, Hu, Huang, Iwamoto, Jon S. Friedland, Jorge Coronel, Kawai, Lilia Z. Cabrera, Louis Grandjean, Luz Caviedes, Luz Huaroto, Matthew Z. Dudley, Mirko Zimic, Mitchison, Moore, Moore, Patricia Sheen, Raviglione, Richard Rodriguez, Robert H. Gilman, Scorpio, Sheen, Sheen, Sheen, Steele, Stricof, Víctor Chávez-Pérez, Wells, Willingham   +41 more
core   +2 more sources

Pyrazinamide resistance of novel mutations inpncAand their dynamic behavior

RSC Advances, 2020
We performed several analyses to unveil the pyrazinamide-resistance mechanism of R123P, T76P, G150A, and H71R mutants through molecular dynamics simulations.
Arif Ali, Muhammad Tahir Khan, Abbas Khan, Sajid Ali, Sathishkumar Chinnasamy, Khalid Akhtar, Athar Shafiq, Dong-Qing Wei   +7 more
openaire   +3 more sources

Evolution favors protein mutational robustness in sufficiently large populations [PDF]

, 2007
BACKGROUND: An important question is whether evolution favors properties such as mutational robustness or evolvability that do not directly benefit any individual, but can influence the course of future evolution. Functionally similar proteins can differ
A Meyerhans, A Moya, A Wagner, AA Pakula, Alpan Raval, AM Lesk, BW Matthews, CO Wilke, CO Wilke, CO Wilke, CR Otey, D Posada, DA Drummond, David Chen, DC Krakauer, DJ Lipman, DL Hartl, DM Taverna, DM Taverna, E Bornberg-Bauer, E van Nimwegen, E Zuckerkandl, F Sun, Frances H Arnold, G Piganeau, HH Guo, HJ Barnes, JA Wells, JB Plotkin, JD Bloom, JD Bloom, JD Bloom, JD Bloom, JD Bloom, Jesse D Bloom, JM Smith, JM Smith, JN Franklin, KA Bava, L Serrano, M Kimura, M Lynch, M Vignuzzi, MA DePristo, MA Huynen, N Takahata, OG Berg, Ophelia S Venturelli, PC Cirino, PD Sniegowski, R Godoy-Ruiz, R Montville, RE Lenski, S Bershtein, S Brin, S Shafikhani, T Kanagawa, W Besenmatter, X Wang, XJ Zhang, Y Xia, Zhongyi Lu   +61 more
core   +4 more sources

Neutral genetic drift can aid functional protein evolution [PDF]

, 2007
BACKGROUND: Many of the mutations accumulated by naturally evolving proteins are neutral in the sense that they do not significantly alter a protein's ability to perform its primary biological function.
Arnold, Frances H, Bloom, Jesse D, Lu, Zhongyi, Romero, Philip A   +3 more
core   +6 more sources

pncA gene expression and prediction factors on pyrazinamide resistance in Mycobacterium tuberculosis [PDF]

Tuberculosis, 2013
Mutations in the pyrazinamidase (PZAse) coding gene, pncA, have been considered as the main cause of pyrazinamide (PZA) resistance in Mycobacterium tuberculosis. However, recent studies suggest there is no single mechanism of resistance to PZA. The pyrazinoic acid (POA) efflux rate is the basis of the PZA susceptibility Wayne test, and its quantitative
Sheen, Patricia, Lozano, Katherine, Gilman, Robert H, Valencia, Hugo J, Loli, Sebastian, Fuentes, Patricia, Grandjean, Louis, Zimic, Mirko   +7 more
openaire   +3 more sources

Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain [PDF]

, 2015
The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a
Balloux, Francois, Eldholm, Vegard, Lopez, Beatriz, Monteserin, Johana, Rieux, Adrien, Ritacco, Gloria Viviana, Sobkowiak, Benjamin   +6 more
core   +4 more sources

Molecular characterization of the Borrelia burgdorferi in vivo-essential protein PncA [PDF]

Microbiology, 2011
The conversion of nicotinamide to nicotinic acid by nicotinamidase enzymes is a critical step in maintaining NAD+ homeostasis and contributes to numerous important biological processes in diverse organisms. In Borrelia burgdorferi, the nicotinamidase enzyme, PncA, is required for spirochaete survival throughout the infectious cycle.
Jewett, Mollie W., Jain, Sunny, Linowski, Angelika K., Sarkar, Amit, Rosa, Patricia A.   +4 more
openaire   +3 more sources