Results 41 to 50 of about 6,468 (198)

Caecal digestibility as an approximation of ileal protein digestibility evaluation in rats

Journal of Nutritional Science, 2023
The rat model can be used to assess ileal protein digestibility rapidly and in first intention, but no standardised method exists. Our objective was to compare methods to assess protein digestibility, depending on collection site (ileum/caecum) and use ...
Florence M. Guillin, Claire Gaudichon, Laetitia Guérin-Deremaux, Catherine Lefranc-Millot, Nadezda Khodorova, Stéphane Besançon, Juliane Calvez   +6 more
doaj   +1 more source

Combining Plant Proteins to Achieve Amino Acid Profiles Adapted to Various Nutritional Objectives—An Exploratory Analysis Using Linear Programming

Frontiers in Nutrition, 2022
Although plant proteins are often considered to have less nutritional quality because of their suboptimal amino acid (AA) content, the wide variety of their sources, both conventional and emerging, suggests potential opportunities from complementarity ...
Laurianne Dimina, Laurianne Dimina, Didier Rémond, Jean-François Huneau, François Mariotti   +4 more
doaj   +1 more source

Pyrazinamide Resistance and pncA Gene Mutations in Mycobacterium tuberculosis [PDF]

Antimicrobial Agents and Chemotherapy, 2008
ABSTRACT Thirty-four pyrazinamide-resistant and 37 pyrazinamide-susceptible Mycobacterium tuberculosis complex strains were analyzed for pncA gene mutations. None of the sensitive strains had any mutations, apart from silent mutations, whereas all but one resistant strain showed
Pontus, Juréen, Jim, Werngren, Juan-Carlos, Toro, Sven, Hoffner   +3 more
openaire   +2 more sources

Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms [PDF]

Antimicrobial Agents and Chemotherapy, 1997
A gene (pncA) with mutations associated with pyrazinamide resistance in Mycobacterium tuberculosis complex members was characterized in 67 pyrazinamide-resistant and 51 pyrazinamide-susceptible isolates recovered from diverse geographic localities and anatomic sites and typed by IS6110 profiling.
S, Sreevatsan, X, Pan, Y, Zhang, B N, Kreiswirth, J M, Musser   +4 more
openaire   +2 more sources

Colorimetric methods for rapid determination of pyrazinamide resistance

International Journal of Mycobacteriology, 2020
Background: Because pyrazinamide (PZA) is only effective for Mycobacterium tuberculosis at an acidic pH, susceptibility tests are more difficult to perform than those for other anti-tuberculosis (TB) drugs.
Ahmet Ugur Akbal, Belma Durupinar, Ahmet Yilmaz Coban   +2 more
doaj   +1 more source

Grain boundaries contribute to highly efficient lithium‐ion transport in advanced LiNi0.8Co0.15Al0.05O2 secondary sphere with compact structure

SusMat, 2021
LiNi0.8Co0.15Al0.05O2 (NCA) secondary particles with high tap density have a great potential for high volumetric energy density lithium (Li)‐ion power battery.
Cheng Liu, Heyi Xia, Yinping Wei, Jiabin Ma, Lin Gan, Feiyu Kang, Yan‐Bing He   +6 more
doaj   +1 more source

Esters of pyrazinoic acid are active against pyrazinamide-resistant strains of Mycobacterium tuberculosis and other naturally resistant mycobacteria in vitro and ex vivo within macrophages. [PDF]

, 2015
Pyrazinamide (PZA) is active against major Mycobacterium tuberculosis species (M. tuberculosis, M. africanum, and M. microti) but not against M. bovis and M. avium. The latter two are mycobacterial species involved in human and cattle tuberculosis and in
Carmo, N, Constantino, L, Elsa, Anes, Pires, D, Simões, Marta Filipa, Testa, B, Valente, E   +6 more
core   +1 more source

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide

Nature Communications, 2017
AbstractTuberculosis chemotherapy is dependent on the use of the antibiotic pyrazinamide, which is being threatened by emerging drug resistance. Resistance is mediated through mutations in the bacterial gene pncA. Methods for testing pyrazinamide susceptibility are difficult and rarely performed, and this means that the full spectrum of pncA alleles ...
Yadon, Adam N., Rubin, Eric, Maharaj, Kashmeel, Adamson, John H., Lai, Yi-Pin, Sacchettini, James C., Ioerger, Thomas R., Pym, Alexander S.   +7 more
openaire   +4 more sources

Brucella abortus nicotinamidase (PncA) contributes to its intracellular replication and infectivity in mice [PDF]

FEMS Microbiology Letters, 2004
Brucella spp. are facultative intracellular pathogens that have the ability to survive and multiply in professional and non-professional phagocytes, and cause abortion in domestic animals and undulant fever in humans. The mechanism and factors of virulence are not fully understood.
Suk, Kim, Daisuke, Kurokawa, Kenta, Watanabe, Sou-Ichi, Makino, Toshikazu, Shirahata, Masahisa, Watarai   +5 more
openaire   +2 more sources

MODS-Wayne, a Colorimetric Adaptation of the Microscopic-Observation Drug Susceptibility (MODS) Assay for Detection of Mycobacterium tuberculosis Pyrazinamide Resistance from Sputum Samples. [PDF]

, 2019
Although pyrazinamide (PZA) is a key component of first- and second-line tuberculosis treatment regimens, there is no gold standard to determine PZA resistance.
Alcántara, R, Antiparra, R, Fuentes, P, Gilman, RH, Kirwan, DE, Santos, M, Sheen, P, Zimic, M   +7 more
core   +1 more source