Results 81 to 90 of about 6,468 (198)

Weight Cycling Deregulates Eating Behavior in Mice via the Induction of Durable Gut Dysbiosis

Advanced Science, Volume 12, Issue 32, August 28, 2025.
Weight cycling in Humans is suspected to dysregulate eating behavior. Mice submitted to body weight cycling by alternating western‐type and regular chow diets display increased hedonic appetite when exposed to a palatable diet, reminiscent of binge‐eating episodes.
Mélanie Fouesnard, Adélie Salin, Sandy Ribes, Magali Monnoye, Gaëlle Champeil‐Potokar, Marie‐Sabelle Hjeij, Gwénaëlle Randuineau, Léa Le Gleau, Selma Ben Fradj, Catherine Philippe, Alexandre Benani, Isabelle Denis, Véronique Douard, Gaëlle Boudry   +13 more
wiley   +1 more source

Non- pncA Gene-Mutated but Pyrazinamide-Resistant Mycobacterium tuberculosis: Why Is That? [PDF]

Journal of Clinical Microbiology, 2017
ABSTRACT Pyrazinamide (PZA) is a key component for the effective treatment of drug-susceptible and PZA-susceptible multidrug-resistant (MDR PZA-S ) tuberculosis (TB). pncA gene mutations are usually detected in a clear majority (>90%) of PZA-resistant strains but obviously not in
Jim, Werngren, Erik, Alm, Mikael, Mansjö   +2 more
openaire   +2 more sources

Characterization of the Nicotinamide Adenine Dinucleotide Biosynthesis Pathway and Regulatory Mechanisms in Streptococcus mutans

The FASEB Journal, Volume 39, Issue 14, 31 July 2025.
This research elucidates NAD+ biosynthesis in Streptococcus mutans, revealing reliance on the nicotinic acid salvage pathway and an incomplete PnuC–NadR route. SmNiaR, a nicotinic acid‐responsive transcriptional regulator, orchestrates the transcriptional regulation of this pathway.
Haojie Yu, Dandan Shao, Yuheng Zhao, Shuojie Lv, Ruoxi Tao, Yu Sang, Jie Ren, Paul R Cooper, Qingjing Wang   +8 more
wiley   +1 more source

Linezolid-containing regimens for the treatment of drug-resistant tuberculosis in South African children.

, 2012
BACKGROUND: Treatment options for drug-resistant tuberculosis (DR-TB) are limited. Linezolid has been successfully used to treat DR-TB in adults, but there are few case reports of its use in children for TB.
Hallbauer, UM, Hesseling, AC, Rose, PC, Schaaf, HS, Seddon, JA   +4 more
core   +1 more source

Whole genome sequencing of drug resistant Mycobacterium tuberculosis isolates from a high burden tuberculosis region of North West Pakistan [PDF]

, 2019
Tuberculosis (TB), caused by Mycobacterium tuberculosis bacteria, is a leading infectious cause of mortality worldwide, including in Pakistan. Drug resistant M.
Ali, Sajid, Campino, Susana, Cantillon, Daire M, Clark, Taane G, de Sessions, Paola Florez, Jabbar, Abdul, Khan, Sadiq Noor, Khan, Taj Ali, Muraro Wildner, Leticia, Phelan, Jody E, Rahman, Hazir, Waddell, Simon J   +11 more
core   +2 more sources

pncA gene mutations in reporting pyrazinamide resistance among the MDR-TB suspects

Infection, Genetics and Evolution, 2019
Mutations in pncA gene contributing to PZA resistance was not clearly elucidated in China. To reveal the correlated mutations of pncA gene on pyrazinamide (PZA) resistance. 148 Mycobacterium tuberculosis clinical isolates were included from multi-drug resistant tuberculosis suspects.
Xiaoyuan Wu, Wei Lu, Yan Shao, Honghuan Song, Guoli Li, Yan Li, Limei Zhu, Cheng Chen   +7 more
openaire   +2 more sources

Potassium‐Ion Battery Electrodes from Potassium Ferricyanide Nanoplatelets: Thin Platelets and Thick Electrodes Unlock High Areal Capacity and Excellent Rate Performance

Advanced Energy Materials, Volume 15, Issue 23, June 17, 2025.
This study converts bulk KFC powder into 2D nanoplatelets using a simple liquid‐phase exfoliation. These 2D nanoplatelets are mixed with carbon nanotubes to create porous, conductive, and robust electrodes with thicknesses reaching up to 105 µm. The KFC/SWCNT nanocomposite achieves an areal capacity of 0.65 mAh cm−2 at 20 mA g−1, with a retention of 92%
Harneet Kaur, Bharathi Konkena, Mark McCrystall, Kevin Synnatschke, Cian Gabbett, Jose Munuera, Jack Maughan, Lee Gannon, Ross Smith, Yumei Jiang, Tian Carey, Cormac Mc Guinness, Valeria Nicolosi, Jonathan N Coleman   +13 more
wiley   +1 more source

Tuberculous epididymitis caused by intravesical BCG therapy: a case report [PDF]

, 2003
76歳男性.患者は約4年前に膀胱癌で経尿道的膀胱腫瘍切除術後BCG膀胱内注入療法施行し, その1年後, 排尿困難で経尿道的前立腺切除術を行い, 切除標本中に多数の結核結節を認めたが経過観察中であった.だが今回, 右陰嚢腫大で受診となり, 右精巣上体尾部に無痛性硬結の触知より, 右精巣上体炎と診断してレボフロキサシンを投与を行った.しかし, 硬結は縮小したものの投与中止により増大し, 硬結陰嚢皮膚に形成された瘻孔からは膿の排出が認められた.この膿を塗沫検鏡で観察したところ抗酸菌が検出され ...
内藤, 克輔, 古屋, 智子, 小林, とも子, 平田, 寛, 村谷, 哲郎, 矢野, 誠司, 石津, 和彦   +6 more
core  

Identification, cloning, and expression of the Escherichia coli pyrazinamidase and nicotinamidase gene, pncA [PDF]

Antimicrobial Agents and Chemotherapy, 1996
Pyrazinamide (PZA) is one of the three most important drugs for treatment of Mycobacterium tuberculosis infections. The antibacterial activity of PZA requires a bacterial enzyme, pyrazinamidase (PZAase), which hydrolyzes PZA to form pyrazinoic acid and ammonia. Most PZA-resistant clinical M. tuberculosis isolates lack PZAase activity.
R, Frothingham, W A, Meeker-O'Connell, E A, Talbot, J W, George, K N, Kreuzer   +4 more
openaire   +2 more sources

The Recent Development in the Diagnosis of Mycobacterium tuberculosis

Smart Medicine, Volume 4, Issue 2, June 2025.
Mycobacterium tuberculosis (MTB) remains a major global health challenge due to slow, low‐sensitivity traditional diagnostics. Rapid, highly sensitive point‐of‐care tests are critical for timely diagnosis and treatment, reducing transmission. This study reviews the evolution of MTB diagnostic tests, emphasizing advancements and addressing accessibility
Nimet Temur, Esma Eryilmaz‐ Eren, Ilhami Celik, Ilknur E. Yıldız, Mustafa Nisari, Ilay S. Unal, Cagla Celik, Nilay Ildiz, Ismail Ocsoy   +8 more
wiley   +1 more source