Genetic ablation of calcium-independent phospholipase A2γ induces glomerular injury in mice [PDF]
, 2016 Glomerular visceral epithelial cells (podocytes) play a critical role in the maintenance of glomerular permselectivity. Podocyte injury, manifesting as proteinuria, is the cause of many glomerular diseases. We reported previously that calcium-independent
Aoudjit, Lamine +7 more
core +2 more sources
Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes [PDF]
, 2017 Diabetic nephropathy (DN) is now the single commonest cause of end-stage renal disease (ESRD) worldwide and one of the main causes of death in diabetic patients.
Fernandes, Rosa +3 more
core +3 more sources
British Journal of Pharmacology, Volume 182, Issue 21, Page 5355-5377, November 2025.Background and purpose Diabetic nephropathy (DN) is a common complication of diabetes. Current treatments include renin‐angiotensin‐aldosterone system (RAAS) blockers and sodium‐glucose co‐transporter 2 (SGLT2) inhibitors. The cannabinoid CB1 receptor is a potential therapeutic target.
Océane Pointeau +20 more
wiley +1 more source
Leukocyte-endothelial cell interaction is enhanced in podocalyxin-deficient mice [PDF]
The International Journal of Biochemistry & Cell Biology, 2018 The highly sialoglycosylated extracellular domain of podocalyxin (Podxl) is a constituent of the endothelial glycocalyx of most blood vessels but it is unknown if Podxl plays a prominent role in the function of the glycocalyx as a regulator of leukocyte-endothelial adhesion.
Porras, Gracia +2 more
openaire +3 more sources
A pilot study of changes in urinary podocalyxin levels during normal pregnancy and labor
Romanian Journal of Internal Medicine, 2022 Introduction: Increased urinary podocalyxin, a surrogate marker of podocyte detachment, has been shown in preeclampsia and eclampsia, but there is a paucity of data of the effect of normal pregnancy on its urinary excretion.
De Franco Ylbe Palacios +4 more
doaj +1 more source
Trophoblast-induced changes in C-x-C motif chemokine 10 expression contribute to vascular smooth muscle cell dedifferentiation during spiral artery remodeling. [PDF]
, 2013 Objective- During pregnancy, fetal trophoblast disrupt endothelial cell and vascular smooth muscle cell (VSMC) interactions in spiral arteries of the maternal decidua to enable increased nutritional and oxygen delivery to the fetus.
Begum, R +5 more
core +1 more source
Across Barriers: Blood–Brain and Gut Barrier Signaling in Psychiatric Disorders
Journal of Neurochemistry, Volume 169, Issue 11, November 2025.Biological barrier dysfunction in mood and anxiety disorders. Chronic stress and inflammatory bowel disease converge on systemic inflammation that disrupts the intestinal and blood–brain barriers. Loss of barrier integrity promotes bidirectional gut–brain communication disturbances, heightened neuroimmune activation, and dysregulated signaling pathways,
Luisa Bandeira Binder +5 more
wiley +1 more source
Immunofluorescence Staining of WT-1/Podocalyxin on Mouse Kidney Sections [PDF]
BIO-PROTOCOL, 2019 In glomerular diseases, podocytes are one type of cells involved in dysfunction of glomerular filtration. In these conditions, podocyte proteins expression change. Therefore, immunofluorescent staining of podocytes can be performed to visualize podocyte localization of proteins of interest. In this protocol, we detail a method to stain podocytes with a
Henique, Carole +2 more
openaire +3 more sources
Urinary extracellular vesicles and micro-RNA as markers of acute kidney injury after cardiac surgery
Scientific Reports, 2022 We hypothesised that measuring changes in urinary levels of EV and miR will predict the onset of acute kidney injury in cardiac surgery patients. The study was performed in the cohort of the REVAKI-2 trial.
Douglas Miller +10 more
doaj +1 more source
Co-expression networks in generation of induced pluripotent stem cells. [PDF]
, 2016 We developed an adenoviral vector, in which Yamanaka's four reprogramming factors (RFs) were controlled by individual CMV promoters in a single cassette (Ad-SOcMK). This permitted coordinated expression of RFs (SOX2, OCT3/4, c-MYC and KLF4) in a cell for
Coppola, Giovanni +6 more
core +2 more sources