Results 91 to 100 of about 6,165 (196)

Erythropoietin modulation of podocalyxin and a proposed erythroblast niche

Blood, 2007
AbstractEpo's erythropoietic capacity is ascribed largely to its antiapoptotic actions. In part via gene profiling of bone marrow erythroblasts, Epo is now shown to selectively down-modulate the adhesion/migration factors chemokine receptor-4 (Cxcr4) and integrin alpha-4 (Itga4) and to up-modulate growth differentiation factor-3 (Gdf3), oncostatin-M ...
Pradeep, Sathyanarayana, Madhu P, Menon, Olga, Bogacheva, Oleg, Bogachev, Knut, Niss, William S, Kapelle, Estelle, Houde, Jing, Fang, Don M, Wojchowski   +8 more
openaire   +3 more sources

Spatial Transcriptomic Assessments of Gene Expression Profiles in Human Peri‐Implant Lesions

Journal of Clinical Periodontology, Volume 53, Issue 1, Page 137-151, January 2026.
ABSTRACT Aim To analyse gene expression profiles in human tissue samples obtained from dental implant sites with or without peri‐implantitis. Materials and Methods Soft‐tissue biopsy samples obtained from patients presenting with implants with severe peri‐implantitis and adjacent reference implants with no signs of peri‐implantitis were analysed by ...
C. Dionigi, A. C. Ericson, A. Shikhan, L. Larsson, T. Berglundh   +4 more
wiley   +1 more source

Reconfigurable Microenvironments Uncover Mechano‐Sensing Timescales and Direct Cell Polarity

Advanced Functional Materials, Volume 35, Issue 49, December 2, 2025.
A synthetic DNA‐crosslinked cell culture matrix enables control over the mechanical microenvironment surrounding cells. Independent tuning of stiffness and stress relaxation uncovers distinct timescales of mechano‐sensing that regulate cell behavior.
Syuan‐Ku Hsiao, Markus Mukenhirn, Carsten Werner, Alf Honigmann, Elisha Krieg   +4 more
wiley   +1 more source

The Role of WT1 in Embryonic Development and Normal Organ Homeostasis. [PDF]

, 2016
The Wilms' tumor suppressor gene 1 (Wt1) is critically involved in a number of developmental processes in vertebrates, including cell differentiation, control of the epithelial/mesenchymal phenotype, proliferation, and apoptosis.
Muñoz-Chapuli, Ramon, Wilm, Bettina
core   +1 more source

Leukocyte-endothelial cell interaction is enhanced in podocalyxin-deficient mice [PDF]

The International Journal of Biochemistry & Cell Biology, 2018
The highly sialoglycosylated extracellular domain of podocalyxin (Podxl) is a constituent of the endothelial glycocalyx of most blood vessels but it is unknown if Podxl plays a prominent role in the function of the glycocalyx as a regulator of leukocyte-endothelial adhesion.
Porras, Gracia, Sánchez Ayuso, Matilde, González-Manchón, Consuelo   +2 more
openaire   +3 more sources

Development of a practical sandwich assay to detect human pluripotent stem cells using cell culture media

Regenerative Therapy, 2017
Human pluripotent stem cells are considered to be ideal cell sources for regenerative medicine, but their clinical and industrial application is hindered by their tumorigenic potential.
Hiroaki Tateno, Keiko Hiemori, Kazunari Hirayasu, Nagako Sougawa, Masakazu Fukuda, Masaki Warashina, Makoto Amano, Taku Funakoshi, Yoshifusa Sadamura, Shigeru Miyagawa, Atsuhiro Saito, Yoshiki Sawa, Tomoko Shofuda, Miho Sumida, Yonehiro Kanemura, Masaya Nakamura, Hideyuki Okano, Yasuko Onuma, Yuzuru Ito, Makoto Asashima, Jun Hirabayashi   +20 more
doaj   +1 more source

MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis

Advanced Science, Volume 12, Issue 48, December 29, 2025.
This study uncovers a size‐dependent adhesion paradigm, demonstrating that the glycocalyx protein MUC15 suppresses pancreatic cancer progression by attenuating integrin activation, focal adhesion assembly, and YAP mechanotransduction. Integrating computational modeling and experimental validation, the work reveals a mechanical mechanism by which MUC15 ...
Simei Zhang, Hongyuan Zhu, Zeen Zhu, Shuai Wu, Yiqun Song, Jin Wang, Xinlong Chen, Weikun Qian, Jianpeng Li, Yangyang Yue, Qinhong Xu, Zhiping Ruan, Qing Li, Yaomin Zhu, Tian Jian Lu, Guy M. Genin, Feng Xu, Zheng Wang, Min Lin   +18 more
wiley   +1 more source

Immunofluorescence Staining of WT-1/Podocalyxin on Mouse Kidney Sections [PDF]

BIO-PROTOCOL, 2019
In glomerular diseases, podocytes are one type of cells involved in dysfunction of glomerular filtration. In these conditions, podocyte proteins expression change. Therefore, immunofluorescent staining of podocytes can be performed to visualize podocyte localization of proteins of interest. In this protocol, we detail a method to stain podocytes with a
Henique, Carole, Lenoir, Olivia, Tharaux, Pierre-Louis   +2 more
openaire   +3 more sources

A pilot study of changes in urinary podocalyxin levels during normal pregnancy and labor

Romanian Journal of Internal Medicine, 2022
Introduction: Increased urinary podocalyxin, a surrogate marker of podocyte detachment, has been shown in preeclampsia and eclampsia, but there is a paucity of data of the effect of normal pregnancy on its urinary excretion.
De Franco Ylbe Palacios, Segovia Natalia, Marx Ylbe Franco, Hoxhaj Rudiona, Palacios Carlos Franco   +4 more
doaj   +1 more source

Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes [PDF]

, 2017
Diabetic nephropathy (DN) is now the single commonest cause of end-stage renal disease (ESRD) worldwide and one of the main causes of death in diabetic patients.
Fernandes, Rosa, Lemos, Edite Teixeira de, Mega, Cristina, Reis, Flávio   +3 more
core   +3 more sources