Results 71 to 80 of about 3,511 (163)

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, Volume 15, Issue 11, 20 March 2026.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, Volume 78, Issue 3, Page 548-557, March 2026.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, for the Lupus Nephritis Classification Steering Committee   +11 more
wiley   +1 more source

A pilot study of changes in urinary podocalyxin levels during normal pregnancy and labor

Romanian Journal of Internal Medicine, 2022
Introduction: Increased urinary podocalyxin, a surrogate marker of podocyte detachment, has been shown in preeclampsia and eclampsia, but there is a paucity of data of the effect of normal pregnancy on its urinary excretion.
De Franco Ylbe Palacios, Segovia Natalia, Marx Ylbe Franco, Hoxhaj Rudiona, Palacios Carlos Franco   +4 more
doaj   +1 more source

LRP4+ Astrocytes: A Unique Subpopulation Crucial for Blood Vessel Maintenance and Function in the Somatosensory Cortex of Normal and 5xFAD Mice

Glia, Volume 74, Issue 2, February 2026.
Lrp4+ astrocytes, uniquely vessel‐associated and GFAP−, are enriched in the pia. They support laminin‐α5+ basement membrane assembly and regulate vessel diameter and blood flow. They are reduced in 5xFAD brains, and their ablation worsens both vascular and Aβ pathology.
Emily Arzola, Gefei Yu, Lei Xiong, Daehoon Lee, Anika Wu, Shriya Paruchuri, Jasmine Skinner, Minghui Wang, Bin Zhang, Lin Mei, Wen‐Cheng Xiong   +10 more
wiley   +1 more source

Urinary podocyte markers in diabetic kidney disease [PDF]

Kidney Research and Clinical Practice
Podocytes are involved in maintaining kidney function and are a major focus of research on diabetic kidney disease (DKD). Urinary biomarkers derived from podocyte fragments and molecules have been proposed for the diagnosis and monitoring of DKD. Various
Chuanlei Li, Cheuk-Chun Szeto
doaj   +1 more source

Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles

Advanced Science, Volume 13, Issue 3, 14 January 2026.
This study presents heparin‐derived nanoparticles (HP‐NPs) as a novel precision medicine platform that combines therapeutic and delivery functions. HP‐NPs target drug‐resistant glioblastoma stem cells, reprogramming them into a drug‐sensitive phenotype and significantly reducing tumor progression.
Vadim Le Joncour, Austin D. Evans, Camilla Karoliina Bergström, Vignesh Kumar Rangasami, Sumanta Samanta, Nithiyanandan Krishnan, Yuji Teramura, Bo Nilsson, Patricia Hedenqvist, Elin Manell, Jons Hilborn, Marianne‐Jensen Waern, Oommen P. Varghese, Pirjo Laakkonen, Oommen P. Oommen   +14 more
wiley   +1 more source

Low and High Pressor Doses of Ang II Lead to Two Distinct Phenotypes of Hypertensive Heart Disease in Mice

APMIS, Volume 134, Issue 1, January 2026.
ABSTRACT Hypertension is a major contributor to cardiovascular diseases, being the most common comorbidity and the biggest risk factor in heart failure with preserved ejection fraction. Angiotensin II (Ang II) is a known hypertension and heart failure inducer in mice, but its role in the causality in phenotype development remains unclear.
Diana Törmä, Tuisku Suoranta, Mimmi Rinta‐Harri, Jarkko Hytönen, Seppo Ylä‐Herttuala, Anna‐Kaisa Ruotsalainen   +5 more
wiley   +1 more source

Spatial Transcriptomic Assessments of Gene Expression Profiles in Human Peri‐Implant Lesions

Journal of Clinical Periodontology, Volume 53, Issue 1, Page 137-151, January 2026.
ABSTRACT Aim To analyse gene expression profiles in human tissue samples obtained from dental implant sites with or without peri‐implantitis. Materials and Methods Soft‐tissue biopsy samples obtained from patients presenting with implants with severe peri‐implantitis and adjacent reference implants with no signs of peri‐implantitis were analysed by ...
C. Dionigi, A. C. Ericson, A. Shikhan, L. Larsson, T. Berglundh   +4 more
wiley   +1 more source

Effects of N–acetyl cysteine on serum podocalyxin and pentraxin levels in an experimental lower extremity ischemia–reperfusion injury model

Revista Científica
Ischemia–reperfusion injury causes oxidative stress and inflammation, leading to skeletal muscle damage. This study investigates the role of N–acetylcysteine in modulating oxidative stress and inflammatory biomarkers specifically Podocalyxin and ...
Emel Sabaz Karakeci, Mustafa Umit Gurbuz   +1 more
doaj   +1 more source

Reconfigurable Microenvironments Uncover Mechano‐Sensing Timescales and Direct Cell Polarity

Advanced Functional Materials, Volume 35, Issue 49, December 2, 2025.
A synthetic DNA‐crosslinked cell culture matrix enables control over the mechanical microenvironment surrounding cells. Independent tuning of stiffness and stress relaxation uncovers distinct timescales of mechano‐sensing that regulate cell behavior.
Syuan‐Ku Hsiao, Markus Mukenhirn, Carsten Werner, Alf Honigmann, Elisha Krieg   +4 more
wiley   +1 more source