Results 121 to 130 of about 6,232 (197)
Advanced Healthcare Materials, Volume 14, Issue 17, July 4, 2025.The study introduces innovative 3D microtissues that replicate the glomerular filtration barrier of the kidney, offering a novel platform for understanding podocytopathies. These microtissues simulate the glomerulus's structure and dynamics, allowing for the modeling of podocyte injuries and drug testing.
Sara Buttό +5 more
wiley +1 more source
Podocalyxin promotes vascular barrier function
, 2019 The CD34-family sialomucin, podocalyxin (Podxl), is broadly expressed on the luminal face of blood vessels in adult mammals; however, its biological function on vascular endothelial cells (vEC) is not well-defined. Here, we reveal specific functions for podocalyxin in maintaining endothelial barriers using HUVEC monolayers as a model in vitro. Detailed
openaire +1 more source
The MAL protein is crucial for proper membrane condensation at the ciliary base, which is required for primary cilium elongation [PDF]
, 2015 The base of the primary cilium contains a zone of condensed membranes whose importance is not known. Here, we have studied the involvement of MAL, a tetraspanning protein that exclusively partitions into condensed membrane fractions, in the condensation ...
Alonso, M.A. +9 more
core +2 more sources
A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis [PDF]
, 2015 During angiogenesis, Rho GTPases influence endothelial cell migration and cell-cell adhesion; however it is not known whether they control formation of vessel lumens, which are essential for blood flow.
A Nishikimi +52 more
core +4 more sources
Podocalyxin in the Diagnosis and Treatment of Cancer
, 2012 Kelly M. McNagny, Michael R. Hughes, Marcia L. Graves, Erin J. DeBruin, Kimberly Snyder, Jane Cipollone, Michelle Turvey, Poh C.
McNagny, K. +9 more
openaire +4 more sources
Renal Failure, 2019 Background: This investigation was managed to explore whether miR-193a in combination with two podocytes, namely, Wilms tumor type 1 (WT1) and podocalyxin (PODXL), were feasible in estimating onset and prognosis of idiopathic membranous nephropathy (IMN).
Wei Zhang, Yeping Ren, Jie Li
doaj +1 more source
The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier [PDF]
, 2017 Podocytes form the outer part of the glomerular filter, where they have to withstand enormous transcapillary filtration forces driving glomerular filtration.
Abe, Takaya +21 more
core +1 more source
Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]
, 2012 Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Abramsson +79 more
core +1 more source
Mechanisms by which heme oxygenase rescue renal dysfunction in obesity
Redox Biology, 2014 Obesity and excessive inflammation/oxidative stress are pathophysiological forces associated with kidney dysfunction. Although we recently showed that heme-oxygenase (HO) improves renal functions, the mechanisms are largely unclear. Moreover, the effects
Joseph Fomusi Ndisang, Shuchita Tiwari
doaj +1 more source