Results 121 to 130 of about 6,165 (196)

Macrophage Derived Galectin‐3 Promotes Renal Fibrosis and Diabetic Kidney Disease by Enhancing TGFβ1 Signaling

Advanced Science, Volume 12, Issue 35, September 18, 2025.
Macrophage‐derived Galectin‐3 amplifies TGFβ1 signaling to drive diabetic kidney fibrosis: a novel therapeutic target. Abstract Over 30% of patients with type 2 diabetes develop diabetic kidney disease (DKD), which has emerged as a major contributor to end stage renal disease.
Yibing Chen, Qian Jiang, Xiaowei Xing, Liu Xu, Qijin Zhao, Qidong Zhang, Jingwen Chen, Chunxiao Ma, Xingfeng Liu, Yinfei Lu, Yanjun Wan, Lijuan Kong, Shaocong Hou, Qian Lu, Bing Cui, Jiankan Guo, Hongdong Huang, Pingping Li   +17 more
wiley   +1 more source

Podocalyxin promotes vascular barrier function

, 2019
The CD34-family sialomucin, podocalyxin (Podxl), is broadly expressed on the luminal face of blood vessels in adult mammals; however, its biological function on vascular endothelial cells (vEC) is not well-defined. Here, we reveal specific functions for podocalyxin in maintaining endothelial barriers using HUVEC monolayers as a model in vitro. Detailed
openaire   +1 more source

DNA methylation map in circulating leukocytes mirrors subcutaneous adipose tissue methylation pattern: a genome-wide analysis from non-obese and obese patients [PDF]

, 2018
The characterization of the epigenetic changes within the obesity-related adipose tissue will provide new insights to understand this metabolic disorder, but adipose tissue is not easy to sample in population-based studies.
Carreira, M. C., Casanueva, Felipe F., Crujeiras, Ana B., Diaz-Lagares, Angel, Esteller, Manel, Gómez, Antonio, Hervas, David, Martínez, J. Alfredo, 1957-, Milagro, Fermín I., Monteiro, M. P., Navas-Carretero, S., Sandoval, Juan   +11 more
core   +1 more source

The MAL protein is crucial for proper membrane condensation at the ciliary base, which is required for primary cilium elongation [PDF]

, 2015
The base of the primary cilium contains a zone of condensed membranes whose importance is not known. Here, we have studied the involvement of MAL, a tetraspanning protein that exclusively partitions into condensed membrane fractions, in the condensation ...
Alonso, M.A., Andrés, G., Bernabé-Rubio, M., Casares-Arias, J., Correas, Isabel, Enrich, C., Fernández-Barrera, J., Rangel Sánchez, Laura, Reales, E., Rentero, C.   +9 more
core   +2 more sources

Multi‐omics profiling identified two epithelioid sarcoma molecular subtypes with distinct signaling and immune characteristics

Cancer Communications, Volume 45, Issue 12, Page 1760-1766, December 2025.
Carine Ngo, Léo Colmet‐Daage, Julien Vibert, Clémence Hénon, Daniel Pissaloux, Alexander Valent, Jia Xiang Jin, Riwan Brillet, Julien Masliah‐Planchon, Gaëlle Pierron, Ludovic Lacroix, Etienne Rouleau, Cyril Roussel‐Simonin, Lilian Lecorgne, Clémence Astier, Marlène Garrido, Rastislav Bahleda, Benjamin Verret, Axel Le Cesne, Charles Honore, Matthieu Faron, Wolf Herman Fridman, Catherine Sautès‐Fridman, Jean‐Michel Coindre, Jean‐Yves Scoazec, Joshua J Waterfall, Franck Bourdeaut, Thomas G. P. Grünewald, Jean‐Yves Blay, Franck Tirode, Sophie Postel‐Vinay   +30 more
wiley   +1 more source

Podocalyxin in the Diagnosis and Treatment of Cancer

, 2012
Kelly M. McNagny, Michael R. Hughes, Marcia L. Graves, Erin J. DeBruin, Kimberly Snyder, Jane Cipollone, Michelle Turvey, Poh C.
McNagny, K., Hughes, M., Graves, M., DeBruin, E., Snyder, K., Cipollone, J., Turvey, M., Tan, P., McColl, S., Roskelley, C.   +9 more
openaire   +4 more sources

Joyeux anniversaire, CD34 ! [PDF]

, 2005
Vingt ans après la première description de l’antigène CD34, cette molécule continue de susciter la curiosité des scientifiques, qui cherchent toujours à élucider la fonction exacte de ce qui est rapidement apparu comme un « marqueur de la cellule souche ...
Chabannon, Christian
core   +1 more source

Application of miR-193a/WT1/PODXL axis to estimate risk and prognosis of idiopathic membranous nephropathy

Renal Failure, 2019
Background: This investigation was managed to explore whether miR-193a in combination with two podocytes, namely, Wilms tumor type 1 (WT1) and podocalyxin (PODXL), were feasible in estimating onset and prognosis of idiopathic membranous nephropathy (IMN).
Wei Zhang, Yeping Ren, Jie Li
doaj   +1 more source

GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. [PDF]

, 2014
Progressive liver fibrosis is characterized by the deposition of collagen by activated hepatic stellate cells (HSCs). Activation of HSCs is a multiple receptor-driven process in which profibrotic signals are enhanced and antifibrotic pathways are ...
Aroonsakool, Nakon, Brenner, David A, De Minicis, Samuele, Dunkel, Ying, Ghosh, Pradipta, Ho, Samuel B, Lopez-Sanchez, Inmaculada, Mittal, Yash, Muranyi, Andrea, Murray, Fiona, Roh, Yoon-Seok, Seki, Ekihiro, Shanmugam, Kandavel, Singh, Shalini   +13 more
core   +1 more source

Erk5 is a mediator to TGFβ1-induced loss of phenotype and function in human podocytes. [PDF]

, 2014
Background: Podocytes are highly specialized cells integral to the normal functioning kidney, however, in diabetic nephropathy injury occurs leading to a compromised phenotype and podocyte dysfunction which critically produces podocyte loss with ...
Binder, Browne, Chuang, Dalla Vestra, Dessapt, Dorado, Drew, Fioretto, Gagliardini, Goldfarb, Hayashi, Herbach, Herman-Edelstein, Huang, Iwano, Khalil, Kim, Kim, Li, Maeda, Marchetti, Niculescu-Duvaz, Pavenstädt, Phanish, Reeves, Regan, Rocco, Saleem, Schiffer, Shishido, Siegel, Suzaki, Vardouli, Wahab, Winn, Woo, Wu, Zhou, Ziyadeh, Ziyadeh   +39 more
core   +2 more sources