Exome sequencing and in vitro studies identified podocalyxin as a candidate gene for focal and segmental glomerulosclerosis [PDF]
, 2014 Our understanding of focal and segmental glomerulosclerosis (FSGS) has advanced significantly from the studies of rare, monogenic forms of the disease.
Barua, Moumita +5 more
core +1 more source
Urinary Nephrin and Podocalyxin Levels as Predictors of Pre-eclampsia in High-Risk Pregnant Women [PDF]
Folia Medica, 2021 Introduction: Pre-eclampsia (PE) is characterized by new-onset hypertension and proteinuria. Damage of podocyte cells has been reported in pre-eclamptic women, thus podocyte specific proteins such as nephrin and podocalyxin could be useful biomarkers in ...
Irena Kostovska +3 more
doaj +3 more sources
Complex polarity: building multicellular tissues through apical membrane traffic [PDF]
, 2016 The formation of distinct subdomains of the cell surface is crucial for multicellular organism development. The most striking example of this is apical-basal polarization.
Adams +157 more
core +1 more source
PcMab-47: Novel Antihuman Podocalyxin Monoclonal Antibody for Immunohistochemistry [PDF]
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2017 Podocalyxin (PODXL) is a CD34-related sialomucin and a well-known marker of embryonic stem cells. PODXL is expressed in many types of tumors including colorectal cancers, breast cancers, and brain tumors. Overexpression of PODXL is an independent predictor of progression, metastasis, and poor outcome.
Ogasawara, Satoshi +9 more
openaire +2 more sources
Biomolecules, 2021 We developed two human-induced pluripotent stem cell (hiPSC)/human embryonic stem cell (hESC)-specific glycan-recognizing mouse antibodies, R-10G and R-17F, using the Tic (JCRB1331) hiPSC line as an antigen. R-10G recognizes a low-sulfate keratan sulfate,
Yuko Nagai +8 more
doaj +1 more source
Development of 'Redox Arrays' for identifying novel glutathionylated proteins in the secretome [PDF]
, 2015 Proteomics techniques for analysing the redox status of individual proteins in complex mixtures tend to identify the same proteins due to their high abundance.
Bottazzi, Barbara +6 more
core +1 more source
Loss of endothelial barrier integrity in mice with conditional ablation of podocalyxin (Podxl) in endothelial cells [PDF]
, 2016 26 p.-6 fig.Podocalyxin (Podxl) has an essential role in the development and function of the kidney glomerular filtration barrier. It is also expressed by vascular endothelia but perinatal lethality of podxl−/− mice has precluded understanding of its ...
González-Manchón, Consuelo +3 more
core +1 more source
Podocalyxin inhibits human embryo implantation in vitro and luminal podocalyxin in putative receptive endometrium is associated with implantation failure in fertility treatment [PDF]
Fertility and Sterility, 2021 To study whether endometrial epithelial podocalyxin (PCX) inhibits implantation of human embryos in vitro and in patients undergoing in vitro fertilization (IVF).We have recently identified PCX as a key negative regulator of endometrial epithelial receptivity.
Sophea Heng +9 more
openaire +3 more sources
Release of podocalyxin into the extracellular space
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011 Peer ...
Fernández, Darío +5 more
openaire +4 more sources
Pharmaceutics, 2020 Cell-surface proteins that can endocytose into brain microvascular endothelial cells serve as promising candidates for receptor-mediated transcytosis across the blood–brain barrier (BBB).
Shingo Ito +6 more
doaj +1 more source