Results 71 to 80 of about 6,232 (197)

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, EarlyView.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, for the Lupus Nephritis Classification Steering Committee   +11 more
wiley   +1 more source

Correlation study of podocyte injur y and kidney function in patients with acute kidney injur y

Journal of Acute Disease, 2016
Objective: To investigate the correlation between the podocyte injury indexes in urine such as nephrin, desmin, P-cadherin, podocin, podocalyxin and CD2-associated protein (CD2AP) and the kidney function in patients with acute kidney injury (AKI ...
You-Gang Feng, Bo Liang, Jun Liu, Ming-Dong Jiang, Hong-Jian Liu, Yi-Qiang Huang, Lu Xiao   +6 more
doaj   +1 more source

Evaluation of serum Podocalyxin in Iraqi women with Polycystic Ovary Syndrome

مجلة كلية الطب, 2023
Background: Polycystic ovarian syndrome is the most common endocrine disease in females of childbearing time of life. Women with polycystic ovarian syndrome  have a higher chance of developing complications such as dyslipidemia, hypertension, and ...
Noor Mohammed Fadhil, Rana ali hamdi
doaj   +1 more source

LRP4+ Astrocytes: A Unique Subpopulation Crucial for Blood Vessel Maintenance and Function in the Somatosensory Cortex of Normal and 5xFAD Mice

Glia, Volume 74, Issue 2, February 2026.
Lrp4+ astrocytes, uniquely vessel‐associated and GFAP−, are enriched in the pia. They support laminin‐α5+ basement membrane assembly and regulate vessel diameter and blood flow. They are reduced in 5xFAD brains, and their ablation worsens both vascular and Aβ pathology.
Emily Arzola, Gefei Yu, Lei Xiong, Daehoon Lee, Anika Wu, Shriya Paruchuri, Jasmine Skinner, Minghui Wang, Bin Zhang, Lin Mei, Wen‐Cheng Xiong   +10 more
wiley   +1 more source

Podocalyxin variants and risk of prostate cancer and tumor aggressiveness [PDF]

Human Molecular Genetics, 2006
We previously reported linkage of a prostate cancer tumor aggressiveness locus to chromosome 7q32-q33, a region also associated with a high frequency of allelic imbalance in prostate tumors. The smallest region of allelic imbalance contains the podocalyxin-like (PODXL) gene, which we evaluate here as a candidate prostate cancer aggressiveness gene ...
Graham, Casey, Phillippa J, Neville, Xin, Liu, Sarah J, Plummer, Mine S, Cicek, Lisa M, Krumroy, Anthony P, Curran, Michelle R, McGreevy, William J, Catalona, Eric A, Klein, John S, Witte   +10 more
openaire   +2 more sources

Effect of ageing and single nucleotide polymorphisms associated with the risk of aggressive prostate cancer in a New Zealand population [PDF]

, 2017
Prostate cancer is one of the most significant male health concerns worldwide, and various researchers carrying out molecular diagnostics have indicated that genetic interactions with biological and behavioral factors play an important role in the ...
Ferguson, Lynnette R., Jabed, Anower, Kallingappa, Prasanna, Kao, Chi Hsiu-Juei, Karunasinghe, Nishi, Marlow, Gareth, Naidu, Vijay, Pallati, Radha, Vaidyanathan, Venkatesh   +8 more
core   +2 more sources

Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles

Advanced Science, Volume 13, Issue 3, 14 January 2026.
This study presents heparin‐derived nanoparticles (HP‐NPs) as a novel precision medicine platform that combines therapeutic and delivery functions. HP‐NPs target drug‐resistant glioblastoma stem cells, reprogramming them into a drug‐sensitive phenotype and significantly reducing tumor progression.
Vadim Le Joncour, Austin D. Evans, Camilla Karoliina Bergström, Vignesh Kumar Rangasami, Sumanta Samanta, Nithiyanandan Krishnan, Yuji Teramura, Bo Nilsson, Patricia Hedenqvist, Elin Manell, Jons Hilborn, Marianne‐Jensen Waern, Oommen P. Varghese, Pirjo Laakkonen, Oommen P. Oommen   +14 more
wiley   +1 more source

Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes. [PDF]

, 2020
The cell surface proteome, the surfaceome, is the interface for engaging the extracellular space in normal and cancer cells. Here we apply quantitative proteomics of N-linked glycoproteins to reveal how a collection of some 700 surface proteins is ...
Coon, Joshua, Kirkemo, Lisa, Leung, Kevin, Riley, Nicholas, Wells, James, Wilson, Gary   +5 more
core  

α5β1 integrin mediates pulmonary epithelial cyst formation [PDF]

, 2017
BACKGROUND: Formation of the epithelial cyst involves the establishment of apical-basolateral polarity through a series of cellular interactions that are in part mediated by the extracellular matrix (ECM).
Lee, Daniel D., Legan, Susan K., Schwarz, Margaret A.   +2 more
core   +1 more source

Low and High Pressor Doses of Ang II Lead to Two Distinct Phenotypes of Hypertensive Heart Disease in Mice

APMIS, Volume 134, Issue 1, January 2026.
ABSTRACT Hypertension is a major contributor to cardiovascular diseases, being the most common comorbidity and the biggest risk factor in heart failure with preserved ejection fraction. Angiotensin II (Ang II) is a known hypertension and heart failure inducer in mice, but its role in the causality in phenotype development remains unclear.
Diana Törmä, Tuisku Suoranta, Mimmi Rinta‐Harri, Jarkko Hytönen, Seppo Ylä‐Herttuala, Anna‐Kaisa Ruotsalainen   +5 more
wiley   +1 more source