Results 71 to 80 of about 6,165 (196)

RENAL‐CHIP: Rejection Evaluation via Non‐Invasive Analysis of Circulating Podocytes With Herringbone‐Chip Isolation Platform

Advanced Science, EarlyView.
RENAL‐CHIP converts 1 mL of peripheral blood into a biopsy‐equivalent readout of renal‐allograft fate. By magnetic capture and release of donor‐derived circulating podocytes through a herringbone microfluidic chip, 84% capture, 96% release and single‐cell RNA evidence of rejection‐specific immunity are achieved.
Juan Song, Yilong Liu, Zeyuan Zheng, Ming Zhu, Yuning Zou, Pei Liu, Yue Zheng, Xiyuan Yu, Jianzhong Zheng, Chen Shao, Huimin Zhang, Chaoyong Yang   +11 more
wiley   +1 more source

Modified Huangqi Chifeng Decoction Attenuates Proteinuria by Reducing Podocyte Injury in a Rat Model of Immunoglobulin a Nephropathy

Frontiers in Pharmacology, 2021
Modified Huangqi Chifeng decoction (MHCD) has been used to reduce proteinuria in immunoglobulin A nephropathy (IgAN) for many years. Previously, we have demonstrated its protective role in glomerular mesangial cells.
Meiying Chang, Bin Yang, Liusheng Li, Yuan Si, Mingming Zhao, Wei Hao, Jinning Zhao, Yu Zhang   +7 more
doaj   +1 more source

Effect of ageing and single nucleotide polymorphisms associated with the risk of aggressive prostate cancer in a New Zealand population [PDF]

, 2017
Prostate cancer is one of the most significant male health concerns worldwide, and various researchers carrying out molecular diagnostics have indicated that genetic interactions with biological and behavioral factors play an important role in the ...
Ferguson, Lynnette R., Jabed, Anower, Kallingappa, Prasanna, Kao, Chi Hsiu-Juei, Karunasinghe, Nishi, Marlow, Gareth, Naidu, Vijay, Pallati, Radha, Vaidyanathan, Venkatesh   +8 more
core   +2 more sources

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Podocalyxin variants and risk of prostate cancer and tumor aggressiveness [PDF]

Human Molecular Genetics, 2006
We previously reported linkage of a prostate cancer tumor aggressiveness locus to chromosome 7q32-q33, a region also associated with a high frequency of allelic imbalance in prostate tumors. The smallest region of allelic imbalance contains the podocalyxin-like (PODXL) gene, which we evaluate here as a candidate prostate cancer aggressiveness gene ...
Graham, Casey, Phillippa J, Neville, Xin, Liu, Sarah J, Plummer, Mine S, Cicek, Lisa M, Krumroy, Anthony P, Curran, Michelle R, McGreevy, William J, Catalona, Eric A, Klein, John S, Witte   +10 more
openaire   +2 more sources

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, Volume 15, Issue 11, 20 March 2026.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Correlation study of podocyte injur y and kidney function in patients with acute kidney injur y

Journal of Acute Disease, 2016
Objective: To investigate the correlation between the podocyte injury indexes in urine such as nephrin, desmin, P-cadherin, podocin, podocalyxin and CD2-associated protein (CD2AP) and the kidney function in patients with acute kidney injury (AKI ...
You-Gang Feng, Bo Liang, Jun Liu, Ming-Dong Jiang, Hong-Jian Liu, Yi-Qiang Huang, Lu Xiao   +6 more
doaj   +1 more source

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, Volume 78, Issue 3, Page 548-557, March 2026.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, for the Lupus Nephritis Classification Steering Committee   +11 more
wiley   +1 more source

Production and characterization of murine monoclonal antibodies against human podocalyxin

Tissue Antigens, 2006
AbstractPodocalyxin (podxl) is a protein with a peptide bone of ∼55.5 kDa that undergoes a post‐translational glycosylation, yielding a final molecular mass from ∼145 to ∼200 kDa. This protein is normally found covering the vascular side of the epithelial glomerular cells, the podocytes, and its presence is essential to maintain a normal renal function.
Rodríguez, Ramón B., Butta, Nora, Larrucea, Susana, Alonso, Sonia, Parrilla, Roberto L.   +4 more
openaire   +3 more sources

Evaluation of serum Podocalyxin in Iraqi women with Polycystic Ovary Syndrome

مجلة كلية الطب, 2023
Background: Polycystic ovarian syndrome is the most common endocrine disease in females of childbearing time of life. Women with polycystic ovarian syndrome  have a higher chance of developing complications such as dyslipidemia, hypertension, and ...
Noor Mohammed Fadhil, Rana ali hamdi
doaj   +1 more source