Results 121 to 130 of about 5,352 (196)

Nephroprotective Efficacy of RAS Blockade in Mice Carrying R140Q Podocin Mutation

, 2014
INTRODUCTION:NPHS2 mutations cause hereditary nephrotic syndrome and progressive renal failure.We recently generated an inducible knock-in mouse model carrying R140Q,the analogue of the most common human mutation R138Q.These mice develop FSGS with ...
Franz Schaefer (576045), Mansoureh Tabatabaeifar (576041), Corinne Antignac (576044), Tanja Wlodkowski (576040), Geraldine Mollet (576043), Helga Denc (567951), Ivana Simic (576042)   +6 more
core   +1 more source

Podocin-Cre;Grb2^flx/flx animals display normal glomerular structure and renal function.

, 2012
(A) Urinalysis of Podocin-Cre;Grb2flx/flx (Cre+) and Grb2flx/flx (Cre-) mice 6 and 18 months after birth. Average measurements and standard deviations were calculated for 3–5 mice from each group.
Samer M. Hussein (117322), Tony Pawson (15870), Julie Ruston (117297), Susan E. Quaggin (58910), W. Rod Hardy (117313), Jianmei Du (117317), Marie Jeansson (117301), Nicolas Bisson (117293), Richard J. Coward (117327), Rachel Vanderlaan (117308)   +9 more
core   +1 more source

Preservation of Urinary Podocyte Markers in Diabetic Kidney Disease by Sodium-Glucose Cotransporter 2 Inhibitor Therapy

Kidney Diseases
Introduction: Sodium-glucose cotransporter 2 inhibitor (SGLT2i) is a standard treatment for kidney and cardiovascular protection in diabetic kidney disease (DKD). We investigated the effect of SGLT2i on the urinary podocyte-associated molecule
Chuanlei Li, Jack Kit-Chung Ng, Gordon Chun-Kau Chan, Winston Wing-Shing Fung, Kai-Ming Chow, Cheuk-Chun Szeto   +5 more
doaj   +1 more source

Modified Huangqi Chifeng decoction alleviates podocyte injury on rat with experimental membranous nephropathy

Renal Failure
Objective This study aims to investigate the therapeutic effects of modified Huangqi Chifeng decoction (MHCD) on proteinuria in membranous nephropathy (MN) and its potential protective effects on podocytes.
Meiying Chang, Xiujie Shi, Bin Yang, Peng Li, Yifan Zhang, Qi Zhang, Yu Zhang   +6 more
doaj   +1 more source

Molecular basis of hereditary nephrotic syndrome : podocin recruits nephrin to lipid rafts

, 2006
Das Kongenitale Nephrotische Syndrom ist ein heterogenes Krankheitsbild, das durch schwere Proteinurie und Niereninsuffizienz gekennzeichnet ist. Mutationen der Gene NPHS1 und NPHS2, die die Proteine Nephrin und Podocin kodieren, führen zu frühzeitig ...
Sernetz, Leonie Anne
core  

The receiver operating curves for models predicting podocin and uPAR performance for diagnosis of MCD and FSGS.

, 2019
(A) ROC curve graphic of plotted sensibility and 1-specificity of Podocin for MCD diagnosis. (B) ROC curve graphic of plotted sensibility and 1-specificity of Podocin for FSGS diagnosis.
Maria Luíza Gonçalves dos Reis Monteiro (6403412), Liliane Silvano Araújo (6403415), Fernando Silva Ramalho (6832157), Marcos Vinicius Silva (4680826), Marlene Antonia Reis (6832163), Rosana Rosa Miranda Corrêa (6832160), Juliana Reis Machado (4748310), Lívia Helena de Morais Pereira (6832148), Marcelo Bernardes da Rocha Reis (6832154), Crislaine Aparecida da Silva (4748319), Laura Penna Rocha (6832151)   +10 more
core   +1 more source

Nephrin and podocin distributions and expressions were changed in the rats after exposure to GDF for 12 weeks.

, 2013
A. Continuous linear pattern of the distribution of nephrin in normal rats. B. Distribution of nephrin was altered in the glomerulus of a rat exposed to GDF, exhibiting an irregular and granular pattern. C.
Shengyu Wang (306423), Chunxia Zheng (306422), Yizhou Lu (306420), Zhihong Liu (112690), Caihong Zeng (306421), Zhongxiu Xu (306419), Weisong Qin (306418)   +6 more
core   +1 more source

Tacrolimus对糖尿病大鼠肾脏足细胞损伤的保护作用及机制

Linchuang shenzangbing zazhi, 2014
目的 探讨Tacrolimus（FK506）是否通过足细胞的保护作用减轻糖尿病大鼠尿白蛋白排泄。方法 将40只大鼠按随机数表法分为对照组（C组）、糖尿病（diabetes mellitus,DM）模型组（DM组）、DM+FK506 0.5mg·kg-1·d-1给药组（FK506 0.5组）及DM+FK506 1.0 mg·kg-1·d-1给药组（FK506 1.0组）,每组10只。采用链脲佐菌素（streptozotocin,STZ）腹腔注射建立糖尿病模型,FK506灌胃给药。4周后大鼠24 ...
朱启金
doaj  

The role of Podocin in organizing protein-lipid-supercomplexes at the glomerular slit diaphragm

, 2007
Gegenstand der vorliegenden Arbeit waren Untersuchungen zur Funktion des murinen PHBd-Proteins Podocin in der Organisation von Protein-Lipid- Superkomplexen an der glomerulären Schlitzmembran. Podocin ist ein essentieller Bestandteil des renalen Filters,
Müller, Roman-Ulrich
core  

MP139STUDY OF URINARY PODOCIN AS MARKER OF LUPUS NEPHRITIS ACTIVITY [PDF]

Nephrology Dialysis Transplantation, 2017
Abdel Bassit ElShaarawy, Maha Behairy, Somia Bawady, Fatma Elzahraa Elsayed   +3 more
openaire   +1 more source