Results 111 to 120 of about 5,352 (196)

A novel domain regulates internalization and degradation of the glomerular slit diaphragm protein podocin

, 2013
Die podozytäre Schlitzmembran ist ein essentieller Teil des glomerulären Filters. Die klinische Manifestation eines nephrotischen Syndroms korreliert mit der Dislokation und dem verstärkten Abbau von Schlitzmembrankomponenten.
Ostendorf, Benjamin Nils
core  

Expression of nephrin and podocin protein in podocytes.

, 2018
Indirect immunofluorescence staining was used to identify podocytes. Podocyte marker proteins nephrin and podocin stained positive, showing green fluorescence; the nuclei were stained with dark blue fluorescence. (400×).
Nai-feng Guo (5204882), Xue-ling Zhu (5204879), Yi-de Zhang (615294), Xiao-lan Chen (615293), Jian-hua Wu (412994), Jing Liu (38537), Xu Chen (432759)   +6 more
core   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

Autophagy in patients with lupus nephritis and its effect on podocyte related protein expression

Linchuang shenzangbing zazhi, 2020
Objective To investigate the autophagy in patients with lupus nephritis(LN)and its effect on podocyte related protein expression.Methods A total of 69 LN patients(LN group),including 50 cases of systemic lupus erythematosus(SLE group)and 50 patients with
LI Zhang-hong, ZHANG Rui-rui, LUO Qiu-ju
doaj  

The relationship among nephrin, podocin, CD2AP, and α-actinin might not be a true ‘interaction’ in podocyte

, 2006
The abnormality of a single podocyte molecule, caused by a single gene mutation, such as NPHS1, NPHS2, CD2AP, and ACTN4, can lead to the hereditary/congenital nephrotic syndromes (NS).
Guan, N, Ding, J., Xing, Y, Fan, Q, Fan, Q., Xing, Y., Guan, N., Ding, J, Zhang, J., Zhang, J   +9 more
core   +1 more source

Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels

, 2006
The prohibitin (PHB)-domain proteins are membrane proteins that regulate a variety of biological activities, including mechanosensation, osmotic homeostasis, and cell signaling, although the mechanism of this regulation is unknown.
Benzing, Thomas, Kunzelmann, Karl, A. Calixto, Walz, Gerd, C. Reinhardt, Harteneck, C., Huber, Tobias B, Thiele, Christoph, M. Bartram, Koos, F., Pavenstadt, Hermann, E. Shirokova, D. Kerjaschki, Krautwurst, Dietmar, T. B. Huber, Chalfie, M., Schermer, Bernhard, M. Simons, H. Hagmann, Muller, R., Hagmann, Henning, M. Chalfie, Krautwurst, D., F. Koos, Hagmann, H., Simons, Matias, Reinhardt, Christian, T. Benzing, Hohne, M., Shirokova, E., Bartram, Malte, Kerjaschki, Dontscho, Schermer, B., R. U. Muller, Reinhardt, C., Muller, Roman Ulrich, Harteneck, Christian, Kerjaschki, D., Shirokova, Elena, Simons, M., H. Pavenstadt, Pavenstadt, H., Hohne, Martin, Koos, Fabienne, C. Harteneck, Calixto, Andrea, M. Hohne, Chalfie, Martin, K. Kunzelmann, Walz, G., Benzing, T., Calixto, A., Thiele, C., Huber, T., Kunzelmann, K., Huber, Tobias B., B. Schermer, G. Walz, C. Thiele, D. Krautwurst, Bartram, M.   +60 more
core   +1 more source

Molecular basis of the functional podocin-nephrin complex:mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains

, 2003
Hereditary nephrotic syndrome is a heterogeneous disease, characterized by heavy proteinuria and renal failure. Mutations of NPHS1 or NPHS2, the genes encoding for nephrin and podocin, lead to early onset of heavy proteinuria, and rapid progression to ...
Simons, Matias, Benzing, Thomas, Huber, Tobias B, Hartleben, Björn, Walz, Gerd, Sernetz, Leonie, Schmidts, Miriam, Gundlach, Enken, Saleem, Moin A   +8 more
core   +1 more source

Correlation of Asymmetric Dimethylarginine With Podocytopathy Markers in Diabetic Kidney Disease Patients

International Journal of Nephrology and Renovascular Disease
Pringgodigdo Nugroho,1 Riahdo Juliarman Saragih,2 Aida Lydia,1 Muhadi Muhadi,3 Harry Isbagio,4,5 Hamzah Shatri,6 Carissa Cornelia Chundiawan,1 Fidel Hermanto1 1Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine,
Nugroho P, Saragih RJ, Lydia A, Muhadi M, Isbagio H, Shatri H, Chundiawan CC, Hermanto F   +7 more
doaj  

Effect of high glucose on nephrin and podocin expression in podocytes.

, 2014
A. Real time PCR analysis of nephrin mRNA expression (n = 5); B. Western blot analysis of nephrin protein expression (n = 6); C. Real time PCR analysis of Podocin mRNA expression (n = 5); D.
Helmy M. Siragy (522465), Caixia Li (522464)   +1 more
core   +1 more source

Tjp1 affects the stability of podocin protein and the maturation of the slit diaphragm.

, 2014
(A) Nephrin and podocin were introduced into L cells with or without Tjp1. The expression of the transfected genes was examined by Western blotting of the cell lysastes and the protein complex formation was analyzed by the immunoprecipitation assay (IP ...
Masahiko Itoh (625217), Taiji Matsusaka (267939), Yasuhiro Horibata (625218), Walter Hunziker (573785), Kazuhiko Nakadate (61020), Hiroyuki Sugimoto (625219), Jianliang Xu (198344)   +6 more
core   +1 more source